氢气医学文献汇总

   自2007年氢气生物学第一篇文章发表后，该文章目前被引用次数已经有200次，仅属于SCI的文献目前可以检索到的有136篇1-136。其中2011年有48篇，2010年48篇，占全部文章的2/3以上，这还不包括2011年发表但没有进入数据库的文章。这些文章并不全部都属于氢气效应研究，有一些可能是其他领域的，但大部分都与氢气效应有关。

    该文献被引用也可从scopus数据进行检索，2012年1月1日引用文献数量为157篇。http://www.scopus.com/results/citedbyresults.url?sort=plf-f&cite=2-s2.0-34250021071&src=s&imp=t&sid=sA8X8SVmEm1h02q920vn-rP%3a30&sot=cite&sdt=a&sl=0&origin=inward&txGid=sA8X8SVmEm1h02q920vn-rP%3a2

   如果使用google学术进行检索，2012年1月1日被引用数量为208次。http://scholar.google.com/scholar?cites=8017042020450919109&as_sdt=2005&sciodt=0,5&hl=zh-CN

2011年48篇

1.      Zhu WJ, Nakayama M, Mori T, Nakayama K, Katoh J, Murata Y, Sato T, Kabayama S, Ito S. Intake of water with high levels of dissolved hydrogen (h(2)) suppresses ischaemia-induced cardio-renal injury in dahl salt-sensitive rats. Nephrology Dialysis Transplantation. 2011;26:2112-2118

2.      Zheng XF, Sun XJ, Xia ZF. Hydrogen resuscitation, a new cytoprotective approach. Clinical and Experimental Pharmacology and Physiology. 2011;38:155-163

3.      Zhao LQ, Zhou CF, Zhang JA, Gao F, Li BL, Chuai YH, Liu C, Cai JM. Hydrogen protects mice from radiation induced thymic lymphoma in balb/c mice. International Journal of Biological Sciences. 2011;7:297-300

4.      Zhang YF, Sun QA, He B, Xiao JA, Wang ZN, Sun XJ. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International journal of cardiology. 2011;148:91-95

5.      Yu P, Wang ZX, Sun XJ, Chen XH, Zeng SY, Chen L, Li SR. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and biophysical research communications. 2011;409:350-355

6.      Yu JG, Zhou RR, Cai GJ. From hypertension to stroke: Mechanisms and potential prevention strategies. Cns Neuroscience & Therapeutics. 2011;17:577-584

7.      Yoon YS, Kim DH, Kim SK, Song SB, Uh Y, Jin D, Qi XF, Teng YC, Lee KJ. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. Food and Chemical Toxicology. 2011;49:1814-1819

8.      Yoon KS, Huang XZ, Yoon YS, Kim SK, Song SB, Chang BS, Kim DH, Lee KJ. Histological study on the effect of electrolyzed reduced water-bathing on uvb radiation-induced skin injury in hairless mice. Biological & pharmaceutical bulletin. 2011;34:1671-1677

9.      Yang X, Guo L, Sun X, Chen X, Tong X. Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta. 2011;32:681-686

10.   Yan HX, Kinjo T, Tian HZ, Hamasaki T, Teruya K, Kabayama S, Shirahata S. Mechanism of the lifespan extension of caenorhabditis elegans by electrolyzed reduced water-participation of pt nanoparticles. Bioscience Biotechnology and Biochemistry. 2011;75:1295-1299

11.   Weis SN, Schunck RVA, Pettenuzzo LF, Krolow R, Matte C, Manfredini V, Peralbad MDR, Vargas CR, Dalmaz C, Wyse ATS, Netto CA. Early biochemical effects after unilateral hypoxia-ischemia in the immature rat brain. International Journal of Developmental Neuroscience. 2011;29:115-120

12.   Wang F, Yu GA, Liu SY, Li JB, Wang JF, Bo LL, Qian LR, Sun XJ, Deng XM. Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. Journal of Surgical Research. 2011;167:E339-E344

13.   Wang C, Li JA, Liu QA, Yang R, Zhang JH, Cao YP, Sun XJ. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of jnk and nf-kappa b activation in a rat model of amyloid-beta-induced alzheimer's disease. Neuroscience letters. 2011;491:127-132

14.   Ueda Y, Kojima T, Oikawa T. Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice. Nutrition Research. 2011;31:863-872

15.   Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Kang DD, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, Fukuda Y. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2011;301:L415-L426

16.   Sun QA, Cai JM, Zhou JR, Tao HY, Zhang JH, Zhang W, Sun XJ. Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical care medicine. 2011;39:765-769

17.   Sun QA, Cai JM, Liu SL, Liu Y, Xu WG, Tao HY, Sun XJ. Hydrogen-rich saline provides protection against hyperoxic lung injury. Journal of Surgical Research. 2011;165:E43-E49

18.   Sun HY, Chen L, Zhou WP, Hu LA, Li LA, Tu QQ, Chang YX, Liu Q, Sun XJ, Wu MC, Wang HY. The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of hepatology. 2011;54:471-480

19.   Song GH, Tian H, Liu J, Zhang HL, Sun XJ, Qin SC. H(2) inhibits tnf-alpha-induced lectin-like oxidized ldl receptor-1 expression by inhibiting nuclear factor kappa b activation in endothelial cells. Biotechnology Letters. 2011;33:1715-1722

20.   Shen L, Wang J, Liu K, Wang CZ, Wang CT, Wu HW, Sun Q, Sun XJ, Jing H. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical research. 2011;36:1501-1511

21.   Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A. Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical hypotheses. 2011;76:117-118

22.   Ni XX, Cai ZY, Fan DF, Liu Y, Zhang RJ, Liu SL, Kang ZM, Liu K, Li RP, Sun XJ, Xu WG. Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviation Space and Environmental Medicine. 2011;82:604-609

23.   Nakai Y, Sato B, Ushiama S, Okada S, Abe K, Arai S. Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience Biotechnology and Biochemistry. 2011;75:774-776

24.   Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K. Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent mr imaging. Magnetic Resonance in Medical Sciences. 2011;10:169-176

25.   Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K. Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Japanese Journal of Radiology. 2011;29:503-512

26.   Liu SL, Liu K, Sun QA, Liu WW, Xu WG, Denoble P, Tao HY, Sun XJ. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine and Biotechnology. 2011

27.   Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neuroscience letters. 2011;487:12-16

28.   Li YP, Hamasaki T, Nakamichi N, Kashiwagi T, Komatsu T, Ye J, Teruya K, Abe M, Yan HX, Kinjo T, Kabayama S, Kawamura M, Shirahata S. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology. 2011;63:119-131

29.   Li QY, Jiang CF, Zu YG, Song Z, Zhang BY, Meng XD, Qiu W, Zhang L. Sfe-co(2) extract from typhonium giganteum engl. Tubers, induces apoptosis in human hepatoma smmc-7721 cells involvement of a ros-mediated mitochondrial pathway. Molecules. 2011;16:8228-8242

30.   Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and n-acetyl-l-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Investigative Ophthalmology & Visual Science. 2011;52:427-433

31.   Kohno M, Mokudai T, Ozawa T, Niwano Y. Free radical formation from sonolysis of water in the presence of different gases. Journal of Clinical Biochemistry and Nutrition. 2011;49:96-101

32.   Kamimura N, Nishimaki K, Ohsawa I, Ohta S. Molecular hydrogen improves obesity and diabetes by inducing hepatic fgf21 and stimulating energy metabolism in db/db mice. Obesity. 2011;19:1396-1403

33.   Jiao L, Zhang J, Li Z, Liu H, Chen Y, Xu S. Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in wistar rat brains. Neuroscience. 2011;182:177-183

34.   Ji Q, Hui KL, Zhang LD, Sun XJ, Li WY, Duan ML. The effect of hydrogen-rich saline on the brain of rats with transient ischemia. Journal of Surgical Research. 2011;168:E95-E101

35.   Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and biophysical research communications. 2011;411:143-149

36.   Hugyecz M, Mracsko E, Hertelendy P, Farkas E, Domoki F, Bari F. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain research. 2011;1404:31-38

37.   Huang Y, Xie KL, Li JP, Xu N, Gong G, Wang GL, Yu YH, Dong HL, Xiong LZ. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain research. 2011;1378:125-136

38.   Huang CS, Kawamura T, Peng XM, Tochigi N, Shigemura N, Billiar TR, Nakao A, Toyoda Y. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa b activation. Biochemical and biophysical research communications. 2011;408:253-258

39.   Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, Matsumura Y, Ishizaka N. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology-Heart and Circulatory Physiology. 2011;301:H1062-H1069

40.   Fujita R, Tanaka Y, Saihara Y, Yamakita M, Ando D, Koyama K. Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. Journal of Physiological Anthropology. 2011;30:195-201

41.   Fang Y, Fu XJ, Gu C, Xu P, Wang Y, Yu WR, Sun Q, Sun XJ, Yao M. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care & Research. 2011;32:E82-E91

42.   Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nature Medicine. 2011;17:1391-1401

43.   Chuai YH, Zhao LQ, Ni J, Sun D, Cui JG, Li BL, Qian LR, Gao F, Cai JM. A possible prevention strategy of radiation pneumonitis: Combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical Science Monitor. 2011;17:HY1-HY4

44.   Chen XA, Zuo QA, Hai YD, Sun XJ. Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production. Medical hypotheses. 2011;76:325-327

45.   Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, Yan RL, Su N, Ruan CP, Sun XJ, Wang QA. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research. 2011;167:316-322

46.   Buchholz BM, Masutani K, Kawamura T, Peng XM, Toyoda Y, Billiar TR, Bauer AJ, Nakao A. Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation. 2011;92:985-992

47.   Bocci V, Zanardi I, Travagli V. Ozone: A new therapeutic agent in vascular diseases. American Journal of Cardiovascular Drugs. 2011;11:73-82

48.   Bimbo LM, Makila E, Laaksonen T, Lehto VP, Salonen J, Hirvonen J, Santos HA. Drug permeation across intestinal epithelial cells using porous silicon nanoparticles. Biomaterials. 2011;32:2625-2633

2010年48篇

49.   Zhou ZY, Tang YP, Xiang J, Wua P, Jin HM, Wang Z, Mori M, Cai DF. Neuroprotective effects of water-soluble ganoderma lucidum polysaccharides on cerebral ischemic injury in rats. Journal of ethnopharmacology. 2010;131:154-164

50.   Zheng J, Liu K, Kang ZM, Cai JM, Liu WW, Xu WG, Li RP, Tao HY, Zhang JH, Sun XJ. Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea & Hyperbaric Medicine. 2010;37:185-192

51.   Yan HX, Tian HZ, Kinjo T, Hamasaki T, Tomimatsu K, Nakamichi N, Teruya K, Kabayama S, Shirahata S. Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water. Bioscience Biotechnology and Biochemistry. 2010;74:2011-2015

52.   Xie KL, Yu YH, Zhang ZS, Liu WB, Pei YP, Xiong LZ, Hou LC, Wang GL. Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model. Shock. 2010;34:495-501

53.   Xie KL, Yu YH, Pei YP, Hou LC, Chen SY, Xiong LZ, Wang GL. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and hmgb1 release. Shock. 2010;34:90-97

54.   Xiang J, Tang YP, Wu P, Gao JP, Cai DF. Chinese medicine nao-shuan-tong attenuates cerebral ischemic injury by inhibiting apoptosis in a rat model of stroke. Journal of ethnopharmacology. 2010;131:174-181

55.   Wolf AM, Asoh S, Hiranuma H, Ohsawa I, Iio K, Satou A, Ishikura M, Ohta S. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. Journal of Nutritional Biochemistry. 2010;21:381-389

56.   Weng YC, Hung KC, Wang JC, Lee YG, Su YF, Lin CY. Binary platinum-ruthenium/nafion electrodes for the detection of hydrogen. Sensors and Actuators B-Chemical. 2010;150:264-270

57.   Ueda Y, Nakajima A, Oikawa T. Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride. Neurochemical research. 2010;35:1510-1515

58.   Taura A, Kikkawa YS, Nakagawa T, Ito J. Hydrogen protects vestibular hair cells from free radicals. Acta Oto-Laryngologica. 2010;130:95-100

59.   Shingu C, Koga H, Hagiwara S, Matsumoto S, Goto K, Yokoi I, Noguchi T. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. Journal of Anesthesia. 2010;24:569-574

60.   Shen MH, He JA, Cai JM, Sun QA, Sun XJ, Huo ZL. Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical hypotheses. 2010;75:235-237

61.   Santos HA, Riikonen J, Salonen J, Makila E, Heikkila T, Laaksonen T, Peltonen L, Lehto VP, Hirvonen J. In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size. Acta Biomaterialia. 2010;6:2721-2731

62.   Saitoh Y, Harata Y, Mizuhashi F, Nakajima M, Miwa N. Biological safety of neutral-ph hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicology and Industrial Health. 2010;26:203-216

63.   Qian LR, Li BL, Cao F, Huang YC, Liu SL, Cai JM, Gao F. Hydrogen-rich pbs protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection. 2010;25:23-29

64.   Qian LR, Li BL, Cai JM, Gao F. The hypothesis of an effective safe and novel radioprotective agent hydrogen-rich solution. West Indian Medical Journal. 2010;59:122-124

65.   Qian LR, Cao F, Cui JG, Wang YC, Huang YC, Chuai YH, Zaho LQ, Jiang H, Cai JM. The potential cardioprotective effects of hydrogen in irradiated mice. Journal of Radiation Research. 2010;51:741-747

66.   Qian LR, Cao F, Cui JG, Huang YC, Zhou XJ, Liu SL, Cai JM. Radioprotective effect of hydrogen in cultured cells and mice. Free radical research. 2010;44:275-282

67.   Pandey BN, Kumar A, Tiwari P, Mishra KP. Radiobiological basis in management of accidental radiation exposure. International Journal of Radiation Biology. 2010;86:613-635

68.   Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I. Protection of the retina by rapid diffusion of hydrogen: Administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Investigative Ophthalmology & Visual Science. 2010;51:487-492

69.   Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (h(2)) produced by water electrolysis: A clinical trial. Nephrology Dialysis Transplantation. 2010;25:3026-3033

70.   Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. Journal of Clinical Biochemistry and Nutrition. 2010;46:140-149

71.   Nakao A, Kaczorowski DJ, Wang YN, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. Journal of Heart and Lung Transplantation. 2010;29:544-553

72.   Lu JM, Lin PH, Yao QZ, Chen CY. Chemical and molecular mechanisms of antioxidants: Experimental approaches and model systems. Journal of Cellular and Molecular Medicine. 2010;14:840-860

73.   Low SP, Williams KA, Canham LT, Voelcker NH. Generation of reactive oxygen species from porous silicon microparticles in cell culture medium. Journal of Biomedical Materials Research Part A. 2010;93A:1124-1131

74.   Liu SL, Sun QA, Tao HY, Sun XJ. Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury. Medical hypotheses. 2010;75:620-622

75.   Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International. 2010;30:958-968

76.   Liu C, Cui JG, Sun Q, Cai JM. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical hypotheses. 2010;74:145-146

77.   Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced alzheimer's disease by reduction of oxidative stress. Brain research. 2010;1328:152-161

78.   Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced ct. British Journal of Radiology. 2010;83:509-514

79.   Kawasaki H, Guan JJ, Tamama K. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochemical and biophysical research communications. 2010;397:608-613

80.   Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation. 2010;90:1344-1351

81.   Kang N, Zhang JH, Qiu F, Tashiro S, Onodera S, Ikejima T. Inhibition of egfr signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Letters. 2010;294:147-158

82.   Kanazuru T, Sato EF, Nagata K, Matsui H, Watanabe K, Kasahara E, Jikumaru M, Inoue J, Inoue M. Role of hydrogen generation by klebsiella pneumoniae in the oral cavity. Journal of Microbiology. 2010;48:778-783

83.   Ji XT, Liu WB, Xie KL, Liu WP, Qu Y, Chao XD, Chen T, Zhou J, Fei Z. Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain research. 2010;1354:196-205

84.   Huang CS, Kawamura T, Toyoda Y, Nakao A. Recent advances in hydrogen research as a therapeutic medical gas. Free radical research. 2010;44:971-982

85.   Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A. Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care. 2010;14

86.   Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research. 2010;38:1893-1903

87.   Hiraoka A, Inaba H, Suzuki E, Kasai K, Suzuki H, Shinohara A, Shirao M, Kubo K, Yoshimura Y. In vitro physicochemical properties of neutral aqueous solution systems (water products as drinks) containing hydrogen gas, 2-carboxyethyl germanium sesquioxide, and platinum nanocolloid as additives. Journal of Health Science. 2010;56:167-174

88.   Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. Journal of Clinical Biochemistry and Nutrition. 2010;46:269-276

89.   George JF, Agarwal A. Hydrogen: Another gas with therapeutic potential. Kidney International. 2010;77:85-87

90.   Fukuyo Y, Hunt CR, Horikoshi N. Geldanamycin and its anti-cancer activities. Cancer Letters. 2010;290:24-35

91.   Farhana A, Guidry L, Srivastava A, Singh A, Hondalus MK, Steyn AJC. Reductive stress in microbes: Implications for understanding mycobacterium tuberculosis disease and persistence. In: Poole RK, ed. Advances in microbial physiology, vol 57. 2010:43-117.

92.   Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, Temesvari P, Bart F. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatric Research. 2010;68:387-392

93.   Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Xu XY, Cai JM, Ruan CP, Su N, Yan RL, Sun XJ, Wang Q. Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats. Biochemical and biophysical research communications. 2010;393:308-313

94.   Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zhang JH, Yuan HB, Sun XJ. Hydrogen-rich saline protects against spinal cord injury in rats. Neurochemical research. 2010;35:1111-1118

95.   Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, Zhang JH. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 2010;169:402-414

96.   Cardinal JS, Zhan JH, Wang YN, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A. Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International. 2010;77:101-109

2009年

97.   Zheng XF, Mao YF, Cai JM, Li YH, Liu WW, Sun PL, Zhang JH, Sun XJ, Yuan HB. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free radical research. 2009;43:478-484

98.   Yun YH, Dong ZY, Lee N, Liu YJ, Xue DC, Guo XF, Kuhlmann J, Doepke A, Halsall HB, Heineman W, Sundaramurthy S, Schulz MJ, Yin ZZ, Shanov V, Hurd D, Nagy P, Li WF, Fox C. Revolutionizing biodegradable metals. Materials Today. 2009;12:22-32

99.  Wagner F, Asfar P, Calzia E, Radermacher P, Szabo C. Bench-to-bedside review: Hydrogen sulfide - the third gaseous transmitter: Applications for critical care. Critical Care. 2009;13

100. Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K. Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS letters. 2009;583:2157-2159

101. Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y, Zhang JH, Denoble PJ, Tao HY, Sun XJ. Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Experimental Biology and Medicine. 2009;234:1212-1219

102. Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T. Effect of dietary turmeric on breath hydrogen. Digestive Diseases and Sciences. 2009;54:1725-1729

103. Saiki R, Nishimura K, Ishii I, Omura T, Okuyama S, Kashiwagi K, Igarashi K. Intense correlation between brain infarction and protein-conjugated acrolein. Stroke; a journal of cerebral circulation. 2009;40:3356-3361

104. Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, Katoh K, Satoh T, Ito S. Biological effects of electrolyzed water in hemodialysis. Nephron Clinical Practice. 2009;112:C9-C15

105. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemotherapy and Pharmacology. 2009;64:753-761

106. Nakao A, Sugimoto R, Billiar TR, McCurry KR. Therapeutic antioxidant medical gas. Journal of Clinical Biochemistry and Nutrition. 2009;44:1-13

107. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology. 2009;34:501-508

108. Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun XJ, Zhang JH. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain research. 2009;1259:90-97

109. Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochemical and biophysical research communications. 2009;381:602-605

110. Li DJ, Tang Q, Shen FM, Su DF, Duan JL, Xi T. Overexpressed alpha 7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in nih3t3 cells. Journal of Bioscience and Bioengineering. 2009;108:85-91

111. Kikuchi K, Ioka A, Oku T, Tanaka Y, Saihara Y, Ogumi Z. Concentration determination of oxygen nanobubbles in electrolyzed water. Journal of colloid and interface science. 2009;329:306-309

112. Kikkawa YS, Nakagawa T, Horie RT, Ito J. Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009;20:689-694

113. Kawahito S, Kitahata H, Oshita S. Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress. World Journal of Gastroenterology. 2009;15:4137-4142

114. Kajiya M, Silva MJB, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochemical and biophysical research communications. 2009;386:11-15

115. Kajiya M, Sato K, Silva MJB, Ouhara K, Do PM, Shanmugam KT, Kawai T. Hydrogen from intestinal bacteria is protective for concanavalin a-induced hepatitis. Biochemical and biophysical research communications. 2009;386:316-321

116. Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y. Molecular hydrogen suppresses fc epsilon ri-mediated signal transduction and prevents degranulation of mast cells. Biochemical and biophysical research communications. 2009;389:651-656

117. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinson's disease. PloS one. 2009;4

118. Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of parkinson's disease. Neuroscience letters. 2009;453:81-85

119. Cheng Y, Qiu F, Ye YC, Guo ZM, Tashiro SI, Onodera S, Ikejima T. Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa b survival pathways in oridonin-treated murine fibrosarcoma l929 cells. Febs Journal. 2009;276:1291-1306

120. Cai JM, Kang ZM, Liu K, Liu WW, Li RP, Zhang JH, Luo X, Sun XJ. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain research. 2009;1256:129-137

121. Bocci V, Borrelli E, Travagli V, Zanardi I. The ozone paradox: Ozone is a strong oxidant as well as a medical drug. Medicinal Research Reviews. 2009;29:646-682

2008年

122. Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, Teruya K, Nishikawa R, Kawahara T, Osada K, Toh K, Abe M, Tian H, Kabayama S, Otsubo K, Morisawa S, Katakura Y, Shirahata S. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & pharmaceutical bulletin. 2008;31:19-26

123. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi H, Maruyama N, Ishigami A. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin c-depleted smp30/gnl knockout mice. Biochemical and biophysical research communications. 2008;375:346-350

124. Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N. Neutral ph hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncology Research. 2008;17:247-255

125. Renault JP, Vuilleumier R, Pommeret S. Hydrated electron production by reaction of hydrogen atoms with hydroxide ions: A first-principles molecular dynamics study. Journal of Physical Chemistry A. 2008;112:7027-7034

126. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein e knockout mice. Biochemical and biophysical research communications. 2008;377:1195-1198

127. Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. Journal of Neuroscience. 2008;28:6239-6249

128. Katsura KI, Takahashi K, Asoh S, Watanabe M, Sakurazawa M, Ohsawa I, Mori T, Igarashi H, Ohkubo S, Katayama Y, Ohta S. Combination therapy with transductive anti-death fnk protein and fk506 ameliorates brain damage with focal transient ischemia in rat. Journal of neurochemistry. 2008;106:258-270

129. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research. 2008;28:137-143

130. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochemical and biophysical research communications. 2008;373:30-35

131. Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N. Oxidative stress plays a critical role in inactivating mutant braf by geldanamycin derivatives. Cancer Research. 2008;68:6324-6330

132. Cai JM, Kang ZM, Liu WW, Luo X, Qiang S, Zhang JH, Ohta SG, Sun XJ, Xu WG, Tao HY, Li RP. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neuroscience letters. 2008;441:167-172

133. Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. American Journal of Transplantation. 2008;8:2015-2024

2007年

134. Wood KC, Gladwin MT. The hydrogen highway to reperfusion therapy. Nature Medicine. 2007;13:673-674

135. Fukuda KI, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochemical and biophysical research communications. 2007;361:670-674

136. Ball J. Recently published papers: More about egdt, experimental therapies and some inconvenient truths. Critical Care. 2007;11