氢气可以治疗糖尿病ED

自2007年日本学者发现氢气治疗脑缺血的效应后，先后有众多学者采用各种细胞和动物模型，已经一些初步临床观察，证明对40多种疾病具有治疗效果。甚至对一些临床上治疗十分棘手的疾病例如，急性胰腺炎、肺动脉高压、胆管阻塞性肝损伤、结肠炎、百草枯中毒、急性放射病、慢性氧中毒、肿瘤化学药物毒性、糖尿病、肥胖、器官移植后器官损伤等都具有治疗效果。这些疾病具有一些共同的特点是存在氧化损伤和炎症反应。氢气可能是通过抗氧化和抗炎症发挥治疗作用。甚至有人试图探讨氢气在镇痛、抗肿瘤方面的可能效果。美国航天局将氢气用于太空辐射的治疗研究。这对一个小小的氢气，和刚刚发现4年的一个效应来讲，进展可以说是非常迅速的。尽管从分子机制上目前仍没有取得明显的突破，但众多学者参与下，相信更多意外发现会相继出现。

关于氢气效应的设想，刚刚获得消息是，来自中山大学第三附属医院的 Chen Jun课题组提出一个大胆的设想，就是氢气可以治疗ED。虽然只是一个观点，但是仍是让人眼前一亮，相信不久可以用客观的证据证明存在这样的效应。从过去一些非正式的观察看，这种效应在人体可能是存在的。至少我了解的就有10个以上的个例出现不同程度的效果。当然这种效果是否有一些心理因素，目前不能确认，需要用比较严格的方法来证明。

过去NO在ED发生中的重要性早为人所熟悉，最近几年硫化氢的作用也引起广泛关注，现在氢气也加入这个行列。难道这些重要气体存在什么内在联系，一些比较原始的功能也许就是这些原始的物质参与调节的。

[PDF] Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis

文章的摘要：Inhalation of hydrogen gas has been proven to be an effective treatment for ischemia-reperfusion injury by selectively reducing hydroxyl and peroxynitrite radicals. There has been considerable evidence of hydrogen’s protective effect against diseases related to oxidative injury, such as the ischemia-reperfusion injury of the brain, liver and heart. More and more studies suggest that radical oxygen species (ROS) play an important role in the development of diabetic erectile dysfunction (ED) and antioxidants can markedly decrease the production of ROS and improve the erectile function.We hypothesize that hydrogen therapy may be a promising, safe and effective treatment fo r diabetic ED by reducing the production of ROS. alteration appears to play an integral role in the development of erectile dysfunction (ED) in diabetic populations.10,11 NO, the principal mediator of penile erection can react with other radicals, such as superoxide anions, to produce peroxynitrite and contribute to numerous pathological conditions such as atherosclerosis and generalized reperfusion injury.12,13

Hydroxyl radical is generated in biological systems from superoxide anions and hydrogen peroxide by the Haber-Weiss reaction or from hydrogen peroxide by the Fenton reaction,14,15 which is the strongest of the oxidant species and reacts indiscriminately with nucleic acids, lipids and proteins.3 A growing number of studies suggested that radical oxygen species (ROS) play an important role in the development of diabetic ED and antioxidants can markedly decrease the production of ROS and improve the erectile function. However, no study has been conducted to investigate the effects of hydrogen in the treatment of diabetic ED, in which ROS play a pivotal role.