氢气可以对抗二氧化碳促进呼吸的效应

二氧化碳的水平是身体内调节呼吸的最重要甚至是决定性因素，早在1978年的一项研究发现，呼吸高压氢气可以对抗高浓度的二氧化碳引起的呼吸促进作用，而且具有剂量效应关系。这是否说明氢气也具有毒性效应？特别是特别高压力下，氢气竟然会干扰正常的呼吸调节。

Toxicology of hydrogen -containing diving environments^☆: I. Antagonism of acute CO₂ effects in the rat by elevated partial pressures of H₂ gas

S.L. Friess, W.V. Hudak, R.D. Boyer

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Received 14 February 1978; Accepted 8 June 1978. Available online 27 September 2004.

Abstract

An anesthetized rat preparation has been used for breathing studies in hyperbaric H₂/O₂/CO₂ atmospheres in which total gaseous pressure was varied in the safe pressure range 8.3 to 19.1 atm. P_CO2 was studied at levels of 0.05 and 0.10 atm. The response variables measured were respiration rate, blood pH, and an isotonic index of diaphragm twitch amplitude, in the presence of He/O₂ gas mixtures used for compression and H₂/O₂/CO₂ saturation gases . The major results indicate that: (1) The rat preparation can be well maintained in H₂/O₂ environments at pressures in excess of 8 atm; (2) elevated P_CO2 in these environments can evoke rapid increases in respiration rate and twitch amplitude, without any marked changes in blood pH; (3) graded increases in P_H2 are able to lower and ultimately abolish the effects of either 0.05 or 0.10 atm levels of CO₂ in breathing parameters; and (4) the intrinsic ability of hyperbaric H₂ to effect a “CO₂-sparing” action on this preparation is greater than that previously seen with hyperbaric argon or helium. The potency sequence for the sparing action by the inert component of the hyperbaric breathing gas is H₂ > Ar > He.

Loader.rt("abs_end"); Loader.feature('lp_embed').qCode("loadEmbedContent(EMBED_APC, 'embedAPCModule');") ^☆Naval Medical Research and Development Command, Research Work Unit No. MR04101001.1020. The opinions and assertions contained herein are the private ones of the writers and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. The experiments conducted herein were conducted according to the principles set forth in the “Guide for the Care and Use of Laboratory Animals”, Institute of Laboratory Resources, National Research Council, DHEW, Pub. No. (NIH) 74-23.

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