我们看到日本的文章后,也进行了几个设想: 证明是否有效, 采用其他模型, 其中心肌模型也是我们想到的. 但是后来发现日本学者也有同样的思考, 文章随后发表.BBRC. 这个文章的发表让我们觉得非常遗憾. 因为我们动作不够快.

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial
Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain and liver by 26
reducing ischemia–reperfusion injury in rodents. When translated into clinical practice, this therapy 27
must be most frequently applied in the treatment of patients with acute myocardial infarction, since 28
angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, 29
we investigate whether H2 gas confers cardioprotection against ischemia–reperfusion injury in rats. In 30
isolated perfused hearts, H2 gas enhances the recovery of left ventricular function following anoxia- 31
reoxygenation. Inhaled H2 gas is rapidly transported and can reach ‘at risk’ ischemic myocardium before 32
coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H2 gas at incom- 33
bustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic 34
parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H2 gas is 35
promising strategy to alleviate ischemia–reperfusion injury coincident with recanalization of coronary 36
artery

在啮齿动物实验中，吸入氢气已经被证实可以通过减轻缺血再灌注损伤而限制脑和肝的梗塞体积。当转化为临床实践时，由于血管成形术再通血管已经是常用治疗手段，这种吸入氢气限制梗塞面积的疗法将被应用于急性心肌梗死患者的治疗。因此，我们通过鼠来研究是否吸入氢气减轻缺血再灌注损伤来起到心脏保护作用。在离体灌注的心脏，氢气可以改善缺氧复氧后左室收缩功能的恢复，在梗死相关动脉的冠脉血流重建前，吸入的氢气可以迅速输送并到达处于危险的缺血心肌，缺血及再灌注期间吸入在不燃水平的氢气可以缩小梗死面积，不改变血流动力学参数，来预防心室的有害重构。因此，在冠脉血运重建时，氢气吸入将成为一种减轻缺血再灌注损伤的非常有希望的措施。