国外报道

http://www.newsrx.com/article.php?articleID=1200183

 

日本学者07年Nature Med（Ohsawa et al. 2007）文章发表后，立刻引起我们的极大兴趣。我们采用不同的脑缺血模型，验证呼吸2%氢气是否可治疗脑缺血损伤，研究结果与日本学者的结果类似，证明呼吸2%氢气确实能够治疗新生儿缺血缺氧后损伤。该内容已发表文章，见Cai JM, Kang ZM, Liu W, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci lett 2008,441(2):167-172. 文章发表后，立刻引起关注，目前已经被引用6次。

这个文章是我们的第一篇关于氢的文章, 比日本学者第一篇晚了1年. 但是我们的速度也是比较快的.

Abstract: Hypoxia-ischemia (HI) brain injury is a major cause of neuronal cell death especially apoptosis in the perinatal period. This study was designated to examine the effect of hydrogen therapy on apoptosis in an established neonatal HI rat pup model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min hypoxia (8% oxygen at 37 °C). Immediately after HI insult, pups were placed into a chamber filled with 2% H2 for 30 min, 60 min, or 120 min, respectively. 24 hr after 2% H2 therapy, the pups were decapitated and brain injury was assessed by 2,3,5-triphenyltetrazoliumchloride (TTC), Nissl, and TUNEL staining, as well as caspase-3, caspase-12 activities in the cortex and hippocampus. H2 treatment in a duration dependent manner significantly reduced the number of positive TUNEL cells and suppressed caspase-3 and -12 activities. These results indicated H2 administration after HI appeared to provide brain protection via inhibition of neuronal apoptosis.

被引用文献目录

Ohsawa I, Nishimaki K, Yamagata K, et al. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.Biochem Biophys Res Commun, 2008, 377(4):1195-8

Ohta S.Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept Nippon Ronen Igakkai Zasshi. 2008,45(4):355-62.

Taniguchi H, Andreasson K.The hypoxic-ischemic encephalopathy model of perinatal ischemia.J Vis Exp. 2008 Nov 19;(21) pii: 955. doi: 10.3791/955

Cai JM, Kang ZM, Liu K, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2008 Nov 27. [Epub ahead of print]

Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S.Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.Cancer Chemother Pharmacol. 2009 Jan 16. [Epub ahead of print]

Gerald A. Matchett, Nancy Fathali, Yu Hasegawa, et al. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models, Brain Res. 2009, doi:10.1016/j.brainres.2008.12.066

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