论文题目：

Evolutionary dynamics of rabies viruses highlights the importance of China rabies transmission in Asia

发表刊物：

Virology (2011), 410, 403-409

作者：

Shengli Meng ^a,  Yan Sun ^b,  Xianfu Wu ^c,  Jianrong Tang ^d,  Gelin Xu ^a,  Yongliang Lei ^e,  Jie Wu ^a,  Jiaxin Yan ^a, Xiaoming Yang ^a,  Charles E. Rupprecht ^c

a  Wuhan Institute of Biological Products, Wuhan, 430060, China

b  Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan, 430074, China

c  Centers for Disease Control and Prevention, Atlanta, Georgia, GA 30333, USA

d  National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

摘要

为探索亚洲狂犬病毒可能的起源、亲缘关系和进化动力学，我们研究了该地区200个狂犬病株完整的核蛋白（N）的基因序列。系统发生的证据表明，所分析的亚洲的这些狂犬病毒都属于基因1型，可继续区分为5个不同的亚群。我们的地理空间和时间分析表明，中国似乎是当代亚洲狂犬病毒的主要来源。理解狂犬病的传播和相关的人类活动，如狗的流动状况，可能有助于亚洲各国通过协同的努力或规划来实现在亚洲控制和消除狂犬病的目标。

abstract

Rabies in Asia is emerging as a serious public health issue. To explore the possible origin, phylogenetic relationships, and evolutionary dynamics of Asian Rabies viruses (RABV), we examined 200 complete nucleoprotein (N) gene sequences from RABV isolates in the region. Phylogeny supported the classification of Asian RABVs into five distinct clusters in lyssavirus genotype 1. Our geospatial and temporal analyses demonstrated that China appears to be the prime source of Asian RABVs. Understanding of rabies transmission and associated human activities, such as dog translocation, can help rabies control and elimination in Asia through collaborative efforts or programs.

全文下载：Evolutionary Dynamics of Rabies Viruses Highlights the Importance of China Rabie.pdf

转载本文请联系原作者获取授权，同时请注明本文来自严家新科学网博客。
链接地址：https://blog.sciencenet.cn/blog-347754-583674.html

上一篇：中国狂犬病病毒变种的历史评估和进化分析
下一篇：过去40年(1969-2009年)间中国狂犬病的传播动力学