论文题目：

A history estimate and evolutionary analysis of rabies virus variants in China

发表刊物：

Journal of General Virology (2010), 91, 759–764

全文下载网址：

http://jgv.sgmjournals.org/content/91/3/759.full.pdf+html

作者：

Pinggang Ming,¹  Jiaxin Yan,1  Simon Rayner,²  Shengli Meng,¹  Gelin Xu,¹  Qing Tang,³  Jie Wu,¹  Jing Luo¹ and Xiaoming Yang¹

1.      Department of Genetic Engineering, Wuhan Institute of Biological Product, 9 Linjiang Street, Wu Chang District, Wuhan 430060, PR China

2.      Department of Bioinformatics, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiaohongshan, Wuhan 430071, PR China

3.      State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street, Xuan Wu District, Beijing 100052, PR China

论文摘要：

为了解中国狂犬病毒的进化动力学，我们收集在过去的40年间来自中国14个省区的55株狂犬病毒样本，并进行了测序。对膜蛋白G的基因序列作了系统比较分析。结果表明，目前在中国流行的狂犬病毒由三个主要类群组成。按贝页斯定理联合方法（Bayesian coalescent methods）进行评估，当前中国流行的狂犬病毒株的最近共同祖先可追溯到1412年（95％置信区间是1006至1736年）。 估计G基因序列的平均替代率是每年每位点3.961X10^-4个碱基替代，与以前报告的狂犬病毒的替代率一致。

To investigate the evolutionary dynamics of rabies virus (RABV) in China, we collected and sequenced 55 isolates sampled from 14 Chinese provinces over the last 40 years and performed a coalescent-based analysis of the G gene. This revealed that the RABV currently circulating in China is composed of three main groups. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current RABV Chinese strains to be 1412 (with a 95% confidence interval of 1006–1736). The estimated mean substitution rate for the G gene sequences (3.961_10”4 substitutions per site per year) was in accordance with previous reports

for RABV. 

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