论文题目：

Transmission dynamics of rabies in China over the last 40 years: 1969–2009

发表刊物：

Journal of Clinical Virology，(2010) 49：47–52

作者：

Shengli Meng ^a , Gelin Xu ^a,∗,,∗, Xianfu Wu ^b, Yongliang Lei ^c , Jiaxin Yan ^a, Susan A. Nadin-Davis ^d,

Hong Liu ^e, JieWu ^a, Dingming Wang ^f , Guanmu Dong ^g, Xiaoming Yang ^a, Charles E. Rupprecht ^b

a  Wuhan Institute of Biological Products, 9# Linjiang Ave., Wuhan, Hubei 430060, China

b  Centers for Disease Control and Prevention, Atlanta, GA, USA

c  Lishui Center for Disease Control and Prevention, Lishui, China

d  Rabies Center of Expertise, Ottawa Laboratory-Fallow Field, Canadian Food Inspection Agency, Ottawa, Ontario, Canada

e  Anhui Center for Disease Control and Prevention, Hefei, China

f  Guizhou Center for Disease Control and Prevention, Guiyang, China

g  National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China

摘要

背景：狂犬病在中国是一种严重的重新出现的人畜共患病。依据历史数据推演狂犬病毒的分子进化和传播模式，可以为未来的疾病控制和预防提供更好的指导方针。

目的：研究中国狂犬病毒的流行病学和进化动力学。

研究设计：分析1969年至2009年间在17个省和3个区(市)收集到的132株狂犬病毒的糖蛋白基因序列的演变。

结果：系统进化分析表明，中国狂犬病毒都属于基因1型，可细分为A～F共6个谱系。谱系A代表广泛分布的到处存在的谱系，而谱系B非常类似于北极狂犬病毒。剩余的谱系C-F主要在东南亚非常流行。中国狂犬病毒的进化速率是每年每位点1.532×10^-4个替代，相应的共同祖先大约存在于1115年。

结论：该系统进化结构表明，中国狂犬病毒既在省内、也向省外传播，与人类的活动密切相关。

Abstract

Background: Rabies is a serious reemerging zoonosis in China. The molecular evolution and transmission patterns of rabies virus inferred from historical data can provide guidelines for better disease control and prevention in the future.

Objectives: To investigate the epidemiology and evolutionary dynamics of the rabies virus in China.

Study design: The molecular evolution of 132 viral glycoprotein gene sequences of Chinese rabies viruses collected in 17 provinces and 3 municipalities between 1969 and 2009 was analyzed.

Results: Phylogenetic analysis revealed that Chinese rabies viruses are subdivided into 6 lineages (A–F) within Lyssavirus genotype 1. Lineage A represents the widely dispersed cosmopolitan lineage while lineage B is closely related to Arctic-like rabies viruses. The remaining lineages (C–F) are typical of those circulating across much of Southeast Asia. The evolutionary rate for Chinese rabies viruswas 1.532×10−4 substitutions per site per year, and the corresponding common ancestor was in about 1115.

Conclusions: The phylogeographic structure demonstrated Chinese rabies viruses have been transmitted intra-provincially and extra-provincially due to human-related activities.

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