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2016拉斯克奖得主William G. Kaelin教授的科学贡献

已有 5128 次阅读 2016-9-14 09:22 |个人分类:科学名人|系统分类:观点评述

今年的“拉斯克基础医学奖”授予三位在人以及大多数动物细胞感知、适应氧气的变化机制方面做出杰出贡献的医学研究者。他们分别是来自哈佛医学院Dana-Farber癌症研究所的William G. Kaelin、英国牛津大学弗朗西斯·克里克研究所（Francis Crick Institute）的Peter J. Ratcliffe以及约翰霍普金斯医学院（Johns Hopkins University School of Medicine）的Gregg Semenza。http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=1002833

William G. Kaelin

所在机构：Dana Farber Cancer Institute

发表数：218

引用数：26626

http://cn.bing.com/images/search?q=William+G.+Kaelin&FORM=HDRSC2

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
William G Kaelin · Peter J Ratcliffe
2008 · Molecular Cell|被引数：1737
Summary HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF stabili…
Endocrinology Biochemistry Biology
引用
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
James Brugarolas · Kui Lei · Rebecca L Hurley · Brendan D Manning · Jan H Reiling · Ernst Hafen · Le…
2004 · Genes & Development|被引数：896
Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of signals. Energy depletion and hypoxia result in mTOR inhibition. While en…
Repressor Phosphorylation Downregulation And Upregulation
引用下载
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage.
Jiangen Gong · Antonio Costanzo · Hongqiong Yang · Gerry Melino · William G Kaelin · Massimo Levrero
1999 · Nature|被引数：1018
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor protein p53 is an imp…
Tyrosine Kinase Alternative Splicing Dna Damage
引用
THE CONCEPT OF SYNTHETIC LETHALITY IN THE CONTEXT OF ANTICANCER THERAPY
William G Kaelin
2005 · Nature Reviews Cancer|被引数：1018
Two genes are synthetic lethal if mutation of either alone is compatible with viability but mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer- relevant mutation shoul…
Conceptual Framework Cancer Nature
引用下载
Role of VHL Gene Mutation in Human Cancer
William Y Kim · William G Kaelin
2004 · Journal of Clinical Oncology|被引数：1039
Medicine
引用
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
Seth J Field · Fongying Tsai · Frank Kuo · Ana M Zubiaga · William G Kaelin · David M Livingston · Stu…
1996 · Cell|被引数：965
Members of the E2F transcription factor family (E2F-1–E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs ha…
Transcription Factor Cell Growth Cell Cycle
引用下载
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
Charles E Stebbins · William G Kaelin · Nikola P Pavletich
1999 · Science|被引数：907
Mutation of the VHL tumor suppressor is associated with the inherited von Hippel–Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and re…
Transcription Bioinformatics Genetics
引用下载
Molecular basis of the VHL hereditary cancer syndrome
William G Kaelin
2002 · Nature Reviews Cancer|被引数：896
Cancer Nature Endocrinology
引用下载
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
William G Kaelin · Wilhelm Krek · William R Sellers · James A Decaprio · F Ajchenbaum · Charles S F…
1992 · Cell|被引数：875
Abstract An expression vector was modified to permit the rapid synthesis of purified, 32P-labeled, glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins. The products were used to scree…
Binding Protein Bioinformatics Genetics
引用
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
Keiichi Kondo · Jeff M Klco · Eijiro Nakamura · Mirna Lechpammer · William G Kaelin
2002 · Cancer Cell|被引数：824
Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product…
Transcription Factor Cancer Research Immunology
引用

http://cn.bing.com/academic/search?q=William+G.+Kaelin&sort=4&FORM=S00060

http://www.pubmedplus.cn/

年份年份趋势图

记录数

占%

01.2016 7 篇6.087%

02.2014 7 篇6.087%

03.2013 7 篇6.087%

04.2011 6 篇5.217%

05.2010 9 篇7.826%

06.2009 8 篇6.957%

07.2008 9 篇7.826%

08.2007 11 篇9.565%

09.2006 7 篇6.087%

10.2005 9 篇7.826%

11.2015 5 篇4.348%

12.2012 5 篇4.348%

13.2011 6 篇5.217%

14.2006 7 篇6.087%

期刊期刊分区中科院期刊分区

记录数

占%

01.cancer cell 16 篇13.913%

02.proc natl acad sci u s a 8 篇6.957%

03.genes dev 6 篇5.217%

04.nature 6 篇5.217%

05.science 6 篇5.217%

06.cell 5 篇4.348%

07.clin cancer res 5 篇4.348%

08.mol cell biol 5 篇4.348%

09.mol cell 4 篇3.478%

10.j clin invest 3 篇2.609%

11.methods enzymol 3 篇2.609%

12.nat rev cancer 3 篇2.609%

13.blood 2 篇1.739%

14.cancer 2 篇1.739%

15.cancer res 2 篇1.739%

16.embo j 2 篇1.739%

17.nat cell biol 2 篇1.739%

18.nat genet 2 篇1.739%

19.am j pathol 1 篇0.870%

20.ann n y acad sci 1 篇0.870%

21.annu rev biochem 1 篇0.870%

22.annu rev pathol 1 篇0.870%

23.biochem biophys res commun 1 篇0.870%

24.cancer biol ther 1 篇0.870%

25.cancer discov 1 篇0.870%

26.cell cycle 1 篇0.870%

27.cell metab 1 篇0.870%

28.cell res 1 篇0.870%

29.circulation 1 篇0.870%

30.curr opin genet dev 1 篇0.870%

31.curr opin pharmacol 1 篇0.870%

32.embo rep 1 篇0.870%

33.endocr pathol 1 篇0.870%

34.endocr relat cancer 1 篇0.870%

35.genome med 1 篇0.870%

36.genome res 1 篇0.870%

37.hematol oncol clin north am 1 篇0.870%

38.j am soc nephrol 1 篇0.870%

39.j biol chem 1 篇0.870%

40.j clin oncol 1 篇0.870%

41.methods mol biol 1 篇0.870%

42.mol cancer res 1 篇0.870%

43.mol imaging 1 篇0.870%

44.n engl j med 1 篇0.870%

45.nat med 1 篇0.870%

46.neoplasia 1 篇0.870%

47.ophthalmology 1 篇0.870%

48.plos biol 1 篇0.870%

49.sci stke 1 篇0.870%

50.semin cancer biol 1 篇0.870%

国家国家分布图

记录数

占%

01.美国 98 篇85.217%

02.中国大陆 3 篇2.609%

03.芬兰 3 篇2.609%

04.加拿大 2 篇1.739%

05.印度 1 篇0.870%

06.日本 1 篇0.870%

07.英国 1 篇0.870%

08.荷兰 1 篇0.870%

09.韩国 1 篇0.870%

大陆城市境外城市

记录数

占%

01.美国波士顿 83 篇72.174%

02.chevy chase 10 篇8.696%

03.美国北卡罗来纳州教堂山镇 5 篇4.348%

04.美国纽约 5 篇4.348%

05.马萨诸塞州剑桥市 5 篇4.348%

06.美国休斯敦 4 篇3.478%

07.美国安德森(安德森癌症中心) 4 篇3.478%

08.美国麻省剑桥市 4 篇3.478%

09.芬兰奥卢 4 篇3.478%

10.brookline 3 篇2.609%

11.kettering.us 3 篇2.609%

12.farber 2 篇1.739%

13.piscataway 2 篇1.739%

14.美国旧金山 2 篇1.739%

15.美国芝加哥 2 篇1.739%

16.albany .ny 1 篇0.870%

17.birmingham.uk 1 篇0.870%

18.blackpool 1 篇0.870%

19.boulevard 1 篇0.870%

20.brunswick 1 篇0.870%

21.canada.alexander 1 篇0.870%

22.fort smith 1 篇0.870%

23.framingham 1 篇0.870%

24.gurgaon 1 篇0.870%

25.hughes 1 篇0.870%

26.jefferson 1 篇0.870%

27.koch 1 篇0.870%

28.la jolla 1 篇0.870%

29.mount sinai 1 篇0.870%

30.new brunswick .ca 1 篇0.870%

31.old bridge 1 篇0.870%

32.port arthur 1 篇0.870%

33.potrero 1 篇0.870%

34.smith.canada 1 篇0.870%

35.university place 1 篇0.870%

36.albany.ca 1 篇0.870%

37.加拿大多伦多 1 篇0.870%

38.加拿大温哥华 1 篇0.870%

39.印度斯利那加 1 篇0.870%

40.日本京都 1 篇0.870%

41.美国华盛顿州温哥华 1 篇0.870%

42.美国圣迭戈 1 篇0.870%

43.美国巴尔的摩霍普金斯 1 篇0.870%

44.美国巴的摩尔 1 篇0.870%

45.美国帕萨迪纳 1 篇0.870%

46.美国弗雷德里克 1 篇0.870%

47.美国洛杉矶 1 篇0.870%

48.美国盐湖城 1 篇0.870%

49.美国米德尔塞克斯 1 篇0.870%

50.美国纽黑文 1 篇0.870%

大陆作者作者与主题词全部作者作者邮件

记录数

占%

01.Kaelin WG 113 篇98.261%

02.Signoretti S 13 篇11.304%

03.Kim WY 10 篇8.696%

04.Minamishima YA 9 篇7.826%

05.Zhang Q 9 篇7.826%

06.Moslehi J 8 篇6.957%

07.Wei W 8 篇6.957%

08.Kondo K 7 篇6.087%

09.Yan Q 7 篇6.087%

10.Koivunen P 6 篇5.217%

11.Li L 6 篇5.217%

12.Schlisio S 6 篇5.217%

13.Bronson RT 5 篇4.348%

14.Chakraborty AA 5 篇4.348%

15.Geisen C 5 篇4.348%

16.Linehan WM 5 篇4.348%

17.Meyerson M 5 篇4.348%

18.Nakamura E 5 篇4.348%

19.Safran M 5 篇4.348%

20.Yang H 5 篇4.348%

21.Zhang GJ 5 篇4.348%

22.George DJ 4 篇3.478%

23.Losman JA 4 篇3.478%

24.Lu G 4 篇3.478%

25.Ohh M 4 篇3.478%

26.Atkins MB 3 篇2.609%

27.Benevolenskaya EV 3 篇2.609%

28.Beroukhim R 3 篇2.609%

29.Bommi-Reddy A 3 篇2.609%

30.Carter BD 3 篇2.609%

31.DePinho RA 3 篇2.609%

32.Ebert BL 3 篇2.609%

33.Figlin RA 3 篇2.609%

34.Hahn WC 3 篇2.609%

35.Ivan M 3 篇2.609%

36.King L 3 篇2.609%

37.Klco JM 3 篇2.609%

38.Kung AL 3 篇2.609%

39.Lee S 3 篇2.609%

40.Liberzon E 3 篇2.609%

41.Liu J 3 篇2.609%

42.Liu W 3 篇2.609%

43.Olenchock BA 3 篇2.609%

44.Padera RF 3 篇2.609%

45.Richardson AL 3 篇2.609%

46.Root DE 3 篇2.609%

47.Shen C 3 篇2.609%

48.Vander Heiden MG 3 篇2.609%

49.Wong KK 3 篇2.609%

50.Zhang J 3 篇2.609%

大陆机构第一作者机构合著机构境外机构

记录数

占%

01.美国丹那法伯肿瘤研究所 70 篇60.870%

02.哈佛医学院 58 篇50.435%

03.布莱根妇女医院 49 篇42.609%

04.霍华德·休斯医学研究所 31 篇26.957%

05.北卡罗来纳大学 6 篇5.217%

06.贝斯以色列女执事医疗中心 5 篇4.348%

07.dana-farber cancer institute and harvard medical school 4 篇3.478%

08.北卡罗来纳大学教堂山分校 3 篇2.609%

09.奥卢大学 3 篇2.609%

10.德克萨斯大学 3 篇2.609%

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主题词主题词搭配主题词与主题词

记录数

占%

01.von hippel-lindau tumor suppressor protein 37 篇32.174%

02.kidney neoplasms 26 篇22.609%

03.tumor suppressor proteins 26 篇22.609%

04.transcription factors 24 篇20.870%

05.carcinoma, renal cell 23 篇20.000%

06.hypoxia-inducible factor 1, alpha subunit 21 篇18.261%

07.ubiquitin-protein ligases 21 篇18.261%

08.mutation 20 篇17.391%

09.gene expression regulation, neoplastic 18 篇15.652%

10.cell line, tumor 16 篇13.913%

11.procollagen-proline dioxygenase 16 篇13.913%

12.dna-binding proteins 15 篇13.043%

13.hypoxia-inducible factor 1 15 篇13.043%

14.neoplasms 14 篇12.174%

15.von hippel-lindau disease 14 篇12.174%

16.nuclear proteins 13 篇11.304%

17.oxygen 12 篇10.435%

18.molecular sequence data 11 篇9.565%

19.rna, small interfering 11 篇9.565%

20.signal transduction 11 篇9.565%

21.base sequence 10 篇8.696%

22.basic helix-loop-helix transcription factors 10 篇8.696%

23.cells, cultured 10 篇8.696%

24.ligases 10 篇8.696%

25.antineoplastic agents 9 篇7.826%

26.genes, tumor suppressor 9 篇7.826%

27.hydroxylation 9 篇7.826%

28.mice, nude 9 篇7.826%

29.models, biological 9 篇7.826%

30.protein binding 9 篇7.826%

31.amino acid sequence 8 篇6.957%

32.cell proliferation 8 篇6.957%

33.gene expression regulation 8 篇6.957%

34.hela cells 8 篇6.957%

35.phenotype 8 篇6.957%

36.anoxia 7 篇6.087%

37.apoptosis 7 篇6.087%

38.cell cycle proteins 7 篇6.087%

39.cell line 7 篇6.087%

40.dioxygenases 7 篇6.087%

41.gene expression profiling 7 篇6.087%

42.liver 7 篇6.087%

43.mice, inbred c57bl 7 篇6.087%

44.cell hypoxia 6 篇5.217%

45.cell transformation, neoplastic 6 篇5.217%

46.mice, knockout 6 篇5.217%

47.mice, transgenic 6 篇5.217%

48.pheochromocytoma 6 篇5.217%

49.retinoblastoma protein 6 篇5.217%

50.rna interference 6 篇5.217%

Substance化学药中药

记录数

占%

01.von hippel-lindau tumor suppressor protein 37 篇32.174%

02.tumor suppressor proteins 26 篇22.609%

03.vhl protein, human 25 篇21.739%

04.transcription factors 24 篇20.870%

05.hypoxia-inducible factor 1, alpha subunit 21 篇18.261%

06.ubiquitin-protein ligases 21 篇18.261%

07.procollagen-proline dioxygenase 16 篇13.913%

08.dna-binding proteins 15 篇13.043%

09.hypoxia-inducible factor 1 15 篇13.043%

10.hif1a protein, human 13 篇11.304%

11.nuclear proteins 13 篇11.304%

12.oxygen 12 篇10.435%

13.rna, small interfering 11 篇9.565%

14.basic helix-loop-helix transcription factors 10 篇8.696%

15.ligases 10 篇8.696%

16.antineoplastic agents 9 篇7.826%

17.endothelial pas domain-containing protein 1 9 篇7.826%

18.cell cycle proteins 7 篇6.087%

19.dioxygenases 7 篇6.087%

20.egln1 protein, mouse 7 篇6.087%

21.retinoblastoma protein 6 篇5.217%

22.vascular endothelial growth factor a 6 篇5.217%

23.enzyme inhibitors 5 篇4.348%

24.hif1a protein, mouse 5 篇4.348%

25.proline 5 篇4.348%

26.ubiquitin 5 篇4.348%

27.dna primers 4 篇3.478%

28.egln1 protein, human 4 篇3.478%

29.egln2 protein, human 4 篇3.478%

30.egln3 protein, human 4 篇3.478%

31.elongin 4 篇3.478%

32.hypoxia-inducible factor-proline dioxygenases 4 篇3.478%

33.immediate-early proteins 4 篇3.478%

34.phd3 protein, mouse 4 篇3.478%

35.proteins 4 篇3.478%

36.proto-oncogene proteins 4 篇3.478%

37.repressor proteins 4 篇3.478%

38.succinate dehydrogenase 4 篇3.478%

39.tor serine-threonine kinases 4 篇3.478%

40.alpha-hydroxyglutarate 3 篇2.609%

41.asparagine 3 篇2.609%

42.cul2 protein, human 3 篇2.609%

43.cullin proteins 3 篇2.609%

44.erythropoietin 3 篇2.609%

45.glutarates 3 篇2.609%

46.isocitrate dehydrogenase 3 篇2.609%

47.luciferases 3 篇2.609%

48.protein kinases 3 篇2.609%

49.recombinant fusion proteins 3 篇2.609%

50.rna, messenger 3 篇2.609%

疾病症状治疗方法物种解剖食品

记录数

占%

01.肿瘤 86 篇74.783%

02.男性泌尿生殖器疾病 36 篇31.304%

03.癌,肿瘤 36 篇31.304%

04.女性泌尿生殖器疾病 35 篇30.435%

05.女性泌尿生殖器疾病和妊娠并发症 35 篇30.435%

06.泌尿系疾病 35 篇30.435%

07.肾疾病 35 篇30.435%

08.泌尿生殖系统癌 34 篇29.565%

09.肾肿瘤 34 篇29.565%

10.泌尿系癌 33 篇28.696%

11.腺和上皮癌 30 篇26.087%

12.腺癌 27 篇23.478%

13.肾细胞癌 24 篇20.870%

14.心血管疾病 19 篇16.522%

15.von hipple-lindau综合征,脑视网膜血管瘤病 18 篇15.652%

16.细胞转化, 肿瘤 18 篇15.652%

17.神经系统疾病 16 篇13.913%

18.血管疾病 16 篇13.913%

19.神经皮肤综合征 15 篇13.043%

20.血管瘤病,多发性血管瘤 14 篇12.174%

21.嗜铬细胞瘤 9 篇7.826%

22.癌形成过程 9 篇7.826%

23.副神经节瘤 8 篇6.957%

24.生殖细胞和胚胎性癌 8 篇6.957%

25.神经外胚瘤 8 篇6.957%

26.神经组织癌 8 篇6.957%

27.血管母细胞瘤 8 篇6.957%

28.神经内分泌瘤 7 篇6.087%

29.血液和淋巴系统疾病 7 篇6.087%

30.视网膜母细胞瘤 7 篇6.087%

31.透明细胞腺癌 7 篇6.087%

32.血液病 6 篇5.217%

33.遗传性癌综合征 6 篇5.217%

34.内分泌系统疾病 5 篇4.348%

35.内分泌腺癌 5 篇4.348%

36.心肌梗塞 5 篇4.348%

37.肾上腺疾病 5 篇4.348%

38.肾上腺癌 5 篇4.348%

39.乳腺癌 4 篇3.478%

40.心肌疾病 4 篇3.478%

41.心脏病 4 篇3.478%

42.扩张型心肌病 4 篇3.478%

43.红细胞增多症 4 篇3.478%

44.贫血 4 篇3.478%

45.dna损伤 3 篇2.609%

46.中风 3 篇2.609%

47.心脏扩大 3 篇2.609%

48.白血病 3 篇2.609%

49.皮肤与结缔组织疾病 3 篇2.609%

50.皮肤疾病 3 篇2.609%

科室学科

记录数

占%

01.生物学 3 篇2.609%

02.肿瘤学 3 篇2.609%

03.化学 2 篇1.739%

04.妇产科学 2 篇1.739%

05.病理学与病理生理学 2 篇1.739%

06.临床检验诊断学 1 篇0.870%

07.免疫学 1 篇0.870%

08.医学遗传学 1 篇0.870%

09.心血管病学 1 篇0.870%

10.普通外科学 1 篇0.870%

11.流行病与卫生统计学 1 篇0.870%

12.生理学 1 篇0.870%

13.病原生物学 1 篇0.870%

14.药学 1 篇0.870%

15.预防医学 1 篇0.870%

北

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