博文
人类遗传学已经关注非编码区SNP了
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A Genome-Wide Screen for Genetic Variants That Modify the Recruitment of REST to Its Target Genes
该文摘要里的一段:Increasing numbers of human diseases are being linked to genetic variants, but our understanding of the mechanistic links leading from DNA sequence to disease phenotype is limited. The majority of disease-causing nucleotide variants fall within the non-protein-coding portion of the genome, making it likely that they act by altering gene regulatory sequences.
大量导致疾病的核酸变异在基因组的非蛋白编码部分,这些区间可能影响基因表达调控.把这段话换个对象可以这样表述:大量重要农艺性状控制等位基因,源自基因表达调控区的变异.既然这样,图位克隆的时候遇到编码区没有多态的情况就不要太诧异了,这可能才是正常情况!
https://blog.sciencenet.cn/blog-479743-555896.html
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