不一定!

举例说明:

Mapping the Core of the Arabidopsis Circadian Clock Defines the Network Structure of the Oscillator

In many organisms, the circadian clock is composed of functionally coupled morning and evening oscillators. In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TIMING OF CAB EXPRESSION 1 (TOC1) was proposed to activate a subset of morning-expressed oscillator genes(这是主流观点). Here, we show that TOC1 does not function as an activator but rather as a general repressor of oscillator gene expression(实验结果把它推翻了). Repression occurs through TOC1 rhythmic association to the promoters of the oscillator genes(进一步阐明抑制机理). Hormone-dependent induction of TOC1 and analysis of RNA interference plants show that TOC1 prevents the activation of morning-expressed genes at night. Our study overturns the prevailing model of the Arabidopsis circadian clock, showing that the morning and evening oscillator loops are connected through the repressing activity of TOC1.

要不人家怎么能发Science呢?当实验结果和流行的理论矛盾的时候,才是真的考验功底的时候,进行研究的人也许会首先怀疑是自己错了，并为此而郁闷.但真正的行家,却会感到无比兴奋.正所谓山穷水复疑无路,柳暗花明又一村!科学研究什么最大?事实最大!这应该是做科研的一个最基本的信仰.