抑郁症和阿尔茨海默病相关性分析

前言

   很多研究发现抑郁症患者存在认知功能障碍，这难道不是一件值得怀疑的事情吗？从临床上看，抑郁症毕竟更多的是情绪和情感上的问题，但是神经变性病更多的是认知、行为、语言和人格方面的异常。从发病病理机制上，看抑郁症更可能跟5-HT和NA等神经递质系统功能紊乱相关，而神经变性病更多的是特定区域的神经元的变性死亡、环路异常和网络障碍。

   但是，我们也不得不说，抑郁症可能会存在记忆力下降、运动减少等行为，可是这些行为往往与患者的情绪低落相关，而非神经变性过程所致。可是难道抑郁症不会增加阿尔茨海默病的发生吗？如果一个人抑郁了，他不是更容易患病吗？因为他不吃饭、睡眠不佳、情绪低落、不学习、不运动，不是更容易导致认知功能障碍吗？

   同时，我们也会注意到所有的神经变性病都会出现精神症状，可能是抑郁、易激惹、冲动、脾气暴躁等，也就是说，神经变性病本身可能存在情绪相关神经递质系统的功能紊乱，这已经为很多研究所证实。

   因此，我们发现了，抑郁了之后就会认知功能障碍，而认知功能障碍了之后又会产生抑郁。因此，两者可能是相互协同的两个精神神经病理过程。今天，我们就来看看相关的研究。

参考文献：

1. Late-life depression and Alzheimer disease: a potential synergy of the underlying mechanisms.

2. Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies.

3. Depression in Alzheimer's disease: epidemiology, mechanisms, and management.

抑郁症和AD的关联

1. 老年人孤独可能会增加老年性痴呆症的发生风险

Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.

2. 抑郁、孤独增加认知功能损害的风险

Loneliness, depression and cognitive function in older U.S. adults.

Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).

Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 USAlzheimer's disease centers.

3. 抑郁症增加脑内Aβ沉积；

Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography.

Association of Cerebral Amyloidosis, Blood Pressure, and Neuronal Injury with Late-Life Onset Depression.

Major Depression May Lead to Elevations in Potentially Neurotoxic Amyloid Beta Species Independently of Alzheimer Disease.

反面报道：Clinicopathological correlates of depression in early Alzheimer's disease in the NACC.

4. 老年人心境障碍和老年性痴呆症的发生风险相关

Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.

5. 抑郁症加重AD的认知功能障碍

The impact of depressive symptoms on health-related quality of life in patients with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease.

6. 抑郁症促进轻度认知功能障碍的患者进展为AD

Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis.

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.

Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: a longitudinal study.

Late-life depression, mild cognitive impairment, and dementia.

7. 同时患有糖尿病和抑郁症的老年人更容易患AD

Comorbid Depression and Diabetes as a Risk for Mild Cognitive Impairment and Alzheimer'sDisease in Elderly Mexican Americans.

Major depressive disorder and type II diabetes mellitus: mechanisms underlying risk forAlzheimer's disease.

8. AD患者存在显著的抑郁症状

The prevalence of depression in Alzheimer's disease: a systematic review and meta-analysis.

Prevalence of anxiety and depression in caregivers of Alzeheimer's dementia patients.

Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease.

Apathy and depression in mild Alzheimer's disease: a cross-sectional study using diagnostic criteria.

9. 抑郁症加重AD的疾病进展和死亡率

Depression and incident Alzheimer disease: the impact of disease severity.

10. 抑郁症可以预测老年人认知功能的损害

Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study.

喜欢我，关注我

拉到最上方标题下，点击上方蓝字关注

搜索公众号名称：神经科学临床和基础

也请你推荐给你身边的医学朋友，感谢你~