范上达
博文
香港大学范上达院士的学术影响力
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许培扬 中国作者论文造假事件（涉嫌造假论文21篇，已撤销2篇） http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=931469
范上达医生
Dr. FAN Sheung Tat
肝脏外科中心主任
外科名誉顾问医生
外科专科医生
香港大学内外全科医学士
香港大学外科硕士
香港大学医学博士
香港大学哲学博士
香港大学科学博士
英国格拉斯哥皇家医学院外科院士
英国爱丁堡皇家外科医学院院士
香港外科医学院院士
香港医学专科学院院士(外科)
http://www.hksh.org.hk/zh-cn/02-doctors/dr-fan-sheung-tat
图片来源存疑，中国工程院院士范上达9年前发表的论文被撤稿
来源：澎湃 / 作者： / 2015-10-28
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10月15日，《美国移植学报》连续发表两篇撤稿声明。
“换肝之父”、中国工程院院士范上达再被曝出学术论文问题。10月27日，据科学微信公众号《知识分子》报道，范上达及其研究团队9年前发表的两篇论文，因图片来源问题，近日被《美国移植学报》（AJT，American Journal of Transplantation）撤销。两篇论文的第一作者和通讯作者均为香港大学李嘉诚医学院外科学系教授万钧（Kwan Man），而原香港大学玛丽医院外科学系主任、肝移植及肝胆胰外科专家范上达为署名作者之一。27日，香港大学李嘉诚医学院回复称，内地网站文章提及的指控，内部调查仍在进行中，本学院目前没有进一步评论或补充。澎湃新闻注意到，10月15日，《美国移植学报》连续发表两篇撤稿声明。
被撤销的论文标题分别为《脂肪激素脂联素和FTY720联用能显著提高小体积脂肪肝移植的存活率》（Fat-Derived Hormone Adiponectin Combined with FTY720 Significantly Improves Small-for-Size Fatty Liver Graft Survival）和《雷帕霉素可以减轻肝硬化患者的肝移植损伤—下调Rho-ROCK-VEGF信号通路的重要性》（Rapamycin Attenuates Liver Graft Injury in Cirrhotic Recipient—The Significance of Down-Regulation of Rho-ROCK-VEGF Pathway），它们分别在线发表于2006年2月10日和2006年1月20日。
《美国移植学报》发表的撤稿声明
《美国移植学报》在撤稿声明中称，脂联素一文中的图片4和图片5的来源令人怀疑，作者对此的回应，不能减轻人们的怀疑和担忧。雷帕霉素一文中的图片3出现了同样的问题。目前，该期刊执行主编艾伦·D·柯克（Allan D. Kirk）与论文作者已经同意撤稿。
中国工程院官网资料显示，范上达，男，1952年出生于香港，原籍广东省潮阳县人。2001年，获香港大学颁发的卓越研究成就奖。2005年，他荣获中国国家科学技术进步奖一等奖，同年当选为中国工程院院士。
范上达于香港玛丽医院接受医学训练，1987年成为该校外科学系讲师，1996年，他领导的团队施行了世界首例成功的成人间活体右半肝移植手术。该手术突破了活体供肝的体积限制，在世界范围内被广泛采用，惠及众多肝病患者。
2008年3月27日，中新网援引香港明报的报道称，国际知名学术期刊《肠胃病学》（Gastroenterology）的编辑审稿时发现，范上达及其研究队伍一篇投稿论文中的一幅图片已经发表，该杂志要求相关研究人员5年内不准向该医学杂志及旗下的杂志投稿。
被《美国移植学报》撤稿的两篇论文
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http://www.bio360.net/news/show/17907.html
发文量 Publications: 343|
被引量 Citations: 4343
研究领域 Fields: Oncology, Anatomy, Pathology
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合作者 Collaborated with 677 co-authors from 1991 to 2011|
被引论文的作者 Cited by 14426 authors
来源 http://academic.research.microsoft.com/Author/18061526/sheung-tat-fan
在执行了世界上第一个成功成人成人右肝活体肝移植 (LDLT) 本港 Hong 于 1996 年，范上达教授和他的团队在玛丽医院之后, Hong 香港中文大学一直努力发奋，制订和完善操作，很大程度上解决器官短缺的问题，挽救无数绝望患者终末期肝脏疾病。今天，右半肝活体肝移植是结果与相媲美，甚至优于已故的活体肝移植肝移植领域的例行程序。肝移植中心在世界各地已广泛的采用。在十一年的应用和改进，多努力定义角色和提高操作的技术设计。在这本书中，范上达教授的先驱，操作详细介绍了活体肝移植，肝移植团队在玛丽医院，常规和各种运营领域的前景的技术方面。全面审查是外科医生、 研究人员、 护士、 医学生、 患者和外行寻求有关活体肝移植的信息的宝贵资源。http://www.microsofttranslator.com/bv.aspx?ref=SERP&br=ro&mkt=zh-CN&dl=zh&lp=EN_ZH-CHS&a=http%3a%2f%2fwww.ldlt.hk%2findex.htm
范上达
努哈 N.Rahbari, O.James 花园, 罗伯特 Padbury, 马克布鲁克-史密斯, Michael 克劳福德, 雷内 · 亚当, 莫里茨 · 科赫, 正敏 Makuuchi, 夏体育德, 克里斯托弗 · Christophi, Simon 班廷, Val Usatoffhttp://academic.research.microsoft.com/io.ashx?type=5&id=49137413&selfId1=18061526&selfId2=0&maxNumber=12&query=
莫里茨 · 科赫, O.James 花园, 罗伯特 Padbury, Nuh N.Rahbari, 雷内 · 亚当, Lorenzo Capussotti, , 行弘横山, Michael 克劳福德, 正敏 Makuuchi, 克里斯托弗 · Christophi, Simon 班廷http://academic.research.microsoft.com/io.ashx?type=5&id=49137421&selfId1=18061526&selfId2=0&maxNumber=12&query=
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发表论文被引排序
- Xin Chen, Siu Tim Cheung, Samuel So, , Christopher Barry, John Higgins, Kin-Man Lai, Jiafu Ji, Sandrine Dudoit, Irene O. L. Ng, Matt van de Rijn, David Botsteinhttp://academic.research.microsoft.com/io.ashx?type=5&id=3137453&selfId1=18061526&selfId2=-1&maxNumber=12&query=Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression ...
- Background: Leakage at the pancreaticoenteric anastomosis remains a common and serious complication after pancreaticoduodenectomy. Over the past decade, various measures directed towards prevention of pancreatic leakage have been studied. This article reviews the available data on the efficacy of these measures.Data sources: The Medline database from 1990 to 2000 was searched for studies on the prevention of pancreatic anastomotic ...
- . Solid-cystic-papillary tumors (SCPTs) of the pancreas are rare. The clinicopathologic features and pathogenesis of these tumors have attracted a number of investigations, but the results remain unclear. We investigated the clinicopathologic data, immunohistochemical expression of the pan-endocrine markers, hormones, steroid receptors, and p53 overexpression in pancreatic SCPTs from eight Chinese patients (seven women, one man) collected ...
- Journal: Journal of The American College of Surgeons - J AMER COLL SURGEONS, vol. 194, no. 5, pp. 592-602, 2002
- Bone marrow comprises heterogeneous cell populations, of which certain progenitors have demonstrated the ability to differentiate into multiple mesenchymal cell lineages. This study demonstrates the bone marrow stromal cells (BMSCs) with intrinsic plasticity to differentiate into hepatocyte-like phenotypes under in vitro induction of hepatocyte growth factor (HGF). BMSCs isolated from rat femurs and tibias were cultured and passaged 3–...Journal: Biochemical and Biophysical Research Communications - BIOCHEM BIOPHYS RES COMMUN, vol. 320, no. 3, pp. 712-716, 2004
- Background: A combination of digital palpation and ultrasonography plays an important role in locating insulinomas intraoperatively. Laparoscopic resection of insulinomas has been described recently, but experience in locating insulinomas during laparoscopy is lacking. Methods: From January 1998 to January 1999, three patients with pancreatic insulinomas underwent laparoscopy and laparoscopic ultrasonography aimed at intraoperative localization and potential resection. The role of ...Journal: Surgical Endoscopy and Other Interventional Techniques - SURG ENDOSC, vol. 14, no. 12, pp. 1131-1135, 2000
- Journal: Clinical Gastroenterology and Hepatology - CLIN GASTROENTEROL HEPATOL, vol. 5, no. 9, pp. 1100-1108, 2007
- Kelvin K. Ng, Jean-Nicolas Vauthey, Timothy M. Pawlik, Gregory Y. Lauwers, Jean-Marc Regimbeau, Jacques Belghiti, Iwao Ikai, Yoshio Yamaoka, Steven A. Curley, David M. Nagorney, Irene O. Ng, http://academic.research.microsoft.com/io.ashx?type=5&id=30697419&selfId1=18061526&selfId2=-1&maxNumber=12&query=Background The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database.Methods The perioperative and long-term outcomes of 404 patients with small HCC (...
- Chi Leung Liu, , Chung Mau Lo, Wai Kuen Tso, Yik Wong, Ronnie T. P. Poon, Chi Ming Lam, Benjamin C. Wong, John WongJournal: Clinical Gastroenterology and Hepatology - CLIN GASTROENTEROL HEPATOL, vol. 3, no. 12, pp. 1238-1244, 2005
- Liver–intestine cadherin (LI-cad) is a non-classical cadherin, which is expressed during intestinal development, but absent in normal liver tissue. Our earlier investigation has detected overexpression of LI-cad in gastric adenocarcinoma and indicated its association with lymph node metastasis. Herein, we found in RT-PCR and TaqMan Q-PCR that LI-cad was identified in HCC cell ...Journal: Biochemical and Biophysical Research Communications - BIOCHEM BIOPHYS RES COMMUN, vol. 311, no. 3, pp. 618-624, 2003
- OBJECTIVE:Hepatocellular carcinoma (HCC) is common in Asia, and the majority are not suitable for curative surgical treatment. We studied the natural history of untreated nonsurgical HCC to examine whether the prognosis has changed with improved supportive treatment and to identify factors affecting survival.METHODS:One hundred and six ethnic Chinese patients with HCC not amenable to curative treatment were ...Journal: American Journal of Gastroenterology - AMER J GASTROENTEROL, vol. 100, no. 9, pp. 1995-2004, 2005
- Identification of Brain-Derived Neurotrophic Factor as a Novel Functional Protein in Hepatocellular Carcinoma(Citations: 29)
Zhen Fan Yang, David W. Ho, Chi Tat Lam, John M. Luk, Ching Tung, Wan Lum, Ching Yu, Ronnie T. Poon,This study aims to identify a novel molecule that may contribute to hepatocarcinogenesis in a rat orthotopic hepatocellular carcinoma model. The hepatocellular carcino- ma model was generated by injection of tumor cells into the left lobe of the liver. Proteomic approaches, including ProteinChip and two-dimensional electrophoresis, were used to identify proteins from serially collected rat serum samples. By both ... - Hepatocellular carcinoma is a highly lethal cancer that typically has poor prognosis. Prognostic markers can help in its clinical management and in understanding the biology of poor prognosis. Through an earlier gene expression study, we identified N-Myc downregulated gene 1 (NDRG1) to be significantly highly expressed in hepatocellular carcinoma compared to nontumor liver. As NDRG1 is a differentiation-related ...
- Published in 2004.
- Shiv Kumar Sarin, Ashish Kumar, John A. Almeida, Yogesh Kumar Chawla, , Hitendra Garg, H. Janaka de Silva, Saeed Sadiq Hamid, Rajiv Jalan, Piyawat Komolmit, George K. Lau, Qing Liuhttp://academic.research.microsoft.com/io.ashx?type=5&id=30871028&selfId1=18061526&selfId2=-1&maxNumber=12&query=The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party ...
- Roberta Pang, John Yuen, Man Fung Yuen, Ching Lung Lai, Terence K W Lee, Kwan Man, Ronnie T P Poon, , Chun M Wong, Irene O L Ng, Yok Lam Kwong, Eric TseThe peptidyl-proplyl-isomerase, PIN1, upregulates β-catenin by inhibiting its interaction with APC. β-catenin accumulation occurs in about 70% of hepatocellular carcinoma (HCC), of which only 20% are due to β-catenin mutations. The role of PIN1 in β-catenin upregulation in HCC was investigated. PIN1 was shown to be overexpressed in more than 50% of HCC. All ...
- Journal: Alimentary Pharmacology & Therapeutics - ALIMENT PHARMACOL THERAPEUT, vol. 19, no. 7, pp. 779-788, 2004
- Background: Laparoscopic resection has been increasingly reported for pancreatic insulinomas. This report evaluates our experience with surgical treatment for pancreatic insulinomas in this era of laparoscopy and reviews the application, safety, and outcome of this surgical approach reported in the literature. Methods: In a consecutive series of 10 patients with pancreatic insulinomas, laparoscopic resection was performed for selected patients after ...Journal: Surgical Endoscopy and Other Interventional Techniques - SURG ENDOSC, vol. 18, no. 2, pp. 297-302, 2004
- Hepatocellular carcinoma (HCC) is a leading cause of cancer death, particularly in Asia where the major eti- ology, chronic hepatitis B virus infection, is endemic. The tumor frequently develops in a background of cir- rhosis, and liver transplantation offers a chance to cure both the tumor and the underlying cirrhosis. The Milan criteria based on tumor size and number as ...
- Background Radiofrequency ablation (RFA) is a recently developed treatment for hepatocellular carcinoma (HCC). Thus far, the prognostic impact of tumor biomarkers has not been evaluated in this treatment. High serum level of vascular endothelial growth factor (VEGF) has been shown to predict microscopic vascular invasion and metastasis in HCC. This study investigated the prognostic significance of pre-treatment serum VEGF level ...
- Bone marrow comprises heterogeneous cell populations and is thought to contain certain progenitors with the ability to differentiate into multiple mesenchymal cell lineages. To identify any differentiation plasticity of adult bone marrow stromal cells (BMSCs) into hepatocyte-like phenotypes, we developed a co-culture model with damaged liver tissue and an animal model of engraftment in cirrhotic liver via intra-...
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