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通用领域
生物医药
Satoshi ō Mura), born in Japan on July 12, 1935, an organic chemist, graduated from the University of Tokyo with a doctor's degree. Winner of the 2015 Nobel Prize in Physiology or Medicine, foreign academician of the Chinese Academy of Engineering, and honorary professor of Beili University [1].
In 1958, after graduating from Yamanashi University, Tomura went to Tokyo Motian Industrial University (senior high school) to teach at night and study part-time; In 1968, he obtained a doctor's degree in pharmacy from Tokyo University; In 1970, he obtained a doctor's degree in chemistry from Tokyo University of Science, which was his second doctor's degree; In 1975, he joined Beili University in Japan as a teacher; In 2005, he was elected as a foreign academician of the Chinese Academy of Engineering; In 2007, he retired from Beili University; In 2015, he won the Nobel Prize in Physiology or Medicine [2]; In 2016, he was awarded the honorary doctorate of Shanghai Jiaotong University [3].
Tomura has been engaged in the research of microbial active substances for a long time, and is a world-class academic leader in this field. The avermectin discovered in the research is praised as one of the most important inventions that have contributed to mankind since the discovery of penicillin in the 20th century [3].
大村智(Satoshi ōmura),1935年7月12日出生于日本,有机化学家,博士学位,毕业于东京大学。2015年诺贝尔生理学或医学奖获得者,中国工程院外籍院士,北里大学荣誉教授 [1] 。
1958年大村智从山梨大学毕业后,到东京墨田工业高校(高中)夜校教书并半工半读;1968年取得东京大学药学博士学位;1970年取得东京理科大学化学博士学位,这是他的第二个博士学位;1975年进入于日本北里大学任教;2005年当选为中国工程院外籍院士;2007年从北里大学荣誉退休;2015年获得诺贝尔生理学或医学奖 [2] ;2016年获颁上海交通大学名誉博士学位 [3] 。
大村智长期从事微生物活性物质研究,是该领域的世界级学科带头人,研究发现的avermectin(阿维菌素)被誉为20世纪自青霉素发现以来对人类贡献的最重大发明之一 [3] 。
https://baike.baidu.com/item/%E5%A4%A7%E6%9D%91%E6%99%BA/9527860?fromModule=lemma_inlink
https://pubmed.ncbi.nlm.nih.gov/27435664/
Review
Angew Chem Int Ed Engl
. 2016 Aug 22;55(35):10190-209.
doi: 10.1002/anie.201602164. Epub 2016 Jul 20.
Affiliations expand
PMID: 27435664
Japanese soil was the origin of one of the most important drugs of the world: ivermectin. No other drug has such importance for the health of millions of people, particularly in the poor regions of the world. The discovery of the parent compounds of the avermectines is described first hand by S. ōmura.
Keywords: anthelmintics; ivermectin; medicinal chemistry; river blindness; worm infestation.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Ivermectin: A Reflection on Simplicity (Nobel Lecture).
Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10184-9. doi: 10.1002/anie.201601492. Epub 2016 May 31.PMID: 27243156 Review.
[Avermectin, from winning the Nobel Prize to "innovation in China"].
Wei Sheng Wu Xue Bao. 2016 Mar 4;56(3):543-58.PMID: 27382795 Review. Chinese.
Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi ōmura.
J Antibiot (Tokyo). 2016 Jan;69(1):1. doi: 10.1038/ja.2015.113. Epub 2015 Oct 21.PMID: 26486878 No abstract available.
Ivermectin: panacea for resource-poor communities?
Trends Parasitol. 2014 Sep;30(9):445-55. doi: 10.1016/j.pt.2014.07.005. Epub 2014 Aug 12.PMID: 25130507 Review.
Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations.
J Antibiot (Tokyo). 2017 May;70(5):495-505. doi: 10.1038/ja.2017.11. Epub 2017 Feb 15.PMID: 28196978 Review.
Water Air Soil Pollut. 2022;233(7):259. doi: 10.1007/s11270-022-05744-0. Epub 2022 Jun 30.PMID: 35789787 Free PMC article. Review.
Assessment of Avermectins-Induced Toxicity in Animals.
Pharmaceuticals (Basel). 2022 Mar 9;15(3):332. doi: 10.3390/ph15030332.PMID: 35337129 Free PMC article. Review.
Int J Mol Sci. 2022 Jan 11;23(2):771. doi: 10.3390/ijms23020771.PMID: 35054958 Free PMC article.
J Nat Med. 2022 Jan;76(1):1-19. doi: 10.1007/s11418-021-01557-3. Epub 2021 Aug 20.PMID: 34415546 Free PMC article. Review.
Natural Products That Changed Society.
Biomedicines. 2021 Apr 26;9(5):472. doi: 10.3390/biomedicines9050472.PMID: 33925870 Free PMC article. Review.
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