发表CNS文章如吃家常便饭的印度美国科学家-Dinshaw J. PATEL

---结构生物学的浮华

在中国，能够发表CNS文章通常会受到热捧！这种情况值得商榷，因为这关乎如何理性进行科学评价的问题。

以印裔美国科学家Dinshaw J. PATEL为例，Dinshaw J. PATEL目前就职于Memorial Sloan-Kettering Cancer Center，是该中心的Member 和 Abby Rockefeller Mauzé冠名主任（Abby Rockefeller Mauzé Chair in Experimental Therapeutics），2009年当选美国科学院院士，2011、2012、2014分别被复旦大学、香港科技大学、中国医学科学院等聘为“讲席”（教授）

看看他2003年到现在的发表物：

Selected Publications: (2003 to present; out of over 450 papers and reviews)
2003

Ye, K., Malinina, L. & Patel, D. J. (2003). Recognition of siRNA by a viral suppressor of RNA silencing.Nature 426, 874-878.2004
Ma, J-B., Ye, K. & Patel, D. J. (2004). Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429, 318-322.
Malinina, L., Malakhova, M. L., Teplov, A., Brown, R. E. & Patel, D. J. (2004). Structural basis for glycosphingolipid transfer specificity. Nature 430, 1048-1053.
2005
Ma, J. B., Yuan, Y. R., Meister, G., Pei, Y., Tuschl, T. & Patel, D. J. (2005). Structural basis for 5’-endspecific recognition of the guide RNA strand by the A. fugidus PIWI protein. Nature 434, 666-670.
Serganov, A., Keiper, S., Malinina, L., Tereschko, V., Skripkin, E., Hobartner, C., Polonskaia, A., Phan,A. T., Wombacher, R., Micura, R., Dauter, Z., Jaschke, A. & Patel, D. J. (2005). Structural basis for Diels-
Alder ribozyme catalyzed carbon-carbon bond formation. Nat. Struct. Mol. Biol. 12, 218-224.
Phan, A. T., Kuryavyi, V., Gaw, H. Y. & Patel, D. J. (2005). Targeting anticancer drugs to a parallelstranded
snapback G-quadruplex formed by five-guanine tracts of the human c-myc promotor. Nat.Chem. Biol. 1, 167-173.
Yuan, Y. R., Ma, J. B., Kuryavyi, V., Pei, Y., Zhadina, M., Meister, G., Chen, H. Y., Dauter, Z., Tuschl, T.& Patel, D. J. (2005). Crystal structure of Aquifex aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol. Cell 19, 405-419.
2006
Serganov, A., Polonskaia, A., Phan, A. T., Breaker, R. R. & Patel, D. J. (2006). Structural basis for gene regulation by a riboswitch that senses thiamine pyrophosphate. Nature 441, 1167-1171.
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Li, H., Ilin, S., Wang, W. K., Wysocka, J., Allis, C. D. & Patel, D. J. (2006). Molecular basis for sitespecific
readout of H3 lysine 4 trimethylation by the BPTF PHD finger. Nature 442, 91-95.
Teplova, M., Yuan, Y. R., Phan, A. T., Malinina, L., Ilin, S., Teplov, A. & Patel, D. J. (2006). Structural
basis for recognition and sequestration of UUUOH 3’-terminii of nascent mRNA polymerase III transcripts
by La autoantigen. Mol. Cell 21, 75-85.
Rechkoblit, O., Malinina, L., Cheng, Y., Kuryavyi, V., Broyde, S., Geacintov, N. & Patel, D. J. (2006).
Stepwise translocation of Dpo4 polymerase during error-free bypass of oxoG lesion. PLoS Biology 4,
25-42.
Ruthenberg, A. J., Wang, W., Graybosch, D. M., Li, H., Allis, C. D., Patel, D. J. & Verdine, G. L. (2006).
Histone H3 lysine 4 methylation state recognition and presentation by the WDR5 module of the MLL1
complex. Nat. Struct. Mol. Biol. 13, 704-712.
Malinina, L., Malakhova, M. L., Kanack, A. T., Brown, R. E. & Patel, D. J. (2006). The liganding mode of
glycolipid transfer protein is controlled by glycolipid acyl structure. PLoS Biology 4, 1996-2011.
Taverna, S. D., Illin, S., Rogers, R. S., Tanny, J. C., Lavender, H., Li, H., Baker, L., Boyle, J., Blair, L. P.,
Chait, B., Patel, D. J., Aitchison, J. D., Tackett, A. J. & Allis, C. D. (2006). Yng1 PHD finger binding to H3
trimethylated at K4 targets promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of
targeted ORFs. Mol. Cell 24, 785-796.
Zhang, X., Yuan, Y-R., Pei, Y., Tuschl, T., Patel, D. J. & Chua, N-H. (2006). Cucumber mosaic virusencoded
2b suppressor inhibits Arabidopsis AGO1 cleavage activity to counter plant defense. Genes
Dev. 20, 3255-3268.
2007
Serganov, A. & Patel, D. J. (2007). Ribozymes and riboswitches: beyond simple RNA. Nat. Rev.
Genetics 8, 776-790.
Ruthenburg, A. J., Li, H., Patel, D. J. & Allis, C. D. (2007). Multivalent engagement of chromatin
modifications by linked binding modules. Nat. Rev. Mol. Cell Biol. 8, 983-994.
Bailor, M. H., Musselman, C., Hansen, A. L., Gulati, K., Patel, D. J. & Al-Hashimi, H. M. (2007).
Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar
couplings. Nat. Protocols 2, 1536-1546.
Li, H., Wang, W. K., Fischle, W., Duncan, E. M., Liang, L., Allis, C. D. & Patel, D. J. (2007). Structural
basis for lower lysine methylation state-specific readout by MBT repeats and an engineered PHD finger
module. Mol. Cell 28, 677-691.
Taverna, S. D., Li, H., Ruthenburg, A. J., Allis, C. D. & Patel, D. J. (2007). How chromatin-binding
modules interpret histone modifications: Lessons from professional pocket pickers. Nat. Struct. Mol.Biol. 14, 1025-1040.
2008
Serganov, A., Huang, L. & Patel, D. J. (2008). Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature 455, 1263-1267.
Wang, Y., Sheng, G., Juranek, S., Tuschl, T. & Patel, D. J. (2008a). Structure of the guide-strandcontaining Argonaute silencing complex. Nature 456, 209-213.
Wang, Y., Li, H., Juranek, S., Sheng, G., Tuschl, T. & Patel, D. J. (2008b). Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 456, 921-926.
Teplova, M. & Patel, D. J. (2008). Structural insights into RNA recognition by the alternate splicing regulator muscleblind like MBNL1. Nat. Struct. Mol. Biol. 15, 1343-1351.
2009
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Xiao, A., Li, H., Shechter, D., Ahn, S. H., Fabrizio, L., Erajument-Bromage, H., Murakami-Ishibe, S.,
Wang, B., Tempst, P., Hofmann, K., Patel, D. J., Elledge, S. J. & Allis, C. D. (2009). WSTF regulates the
DNA damage response of H2A.X via a novel tyrosine kinase activity. Nature 457, 57-62.
Serganov, A., Huang, L. & Patel, D. J. (2009). Coenzyme recognition and gene regulation by a FMN
riboswitch. Nature 458, 233-237.
Wang, G. G., Song, J., Wang, Z., Dormann, H. L., Casadio, F., Luo, J., Patel, D. J. & Allis, C. D. (2009).
Haematopoietic malignancies initiated by dysregulation of a chromatin-binding PHD finger. Nature 459,
847-851.
Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T. & Patel, D. J. (2009). Nucleation,
propagation and cleavage of target RNAs in argonaute silencing complexes. Nature 461, 754-761.
Zhao, Q., Rank, G., Tan, Y. T., Li, H., Moritz, R. L., Simpson, R. J., Cerruti, L., Curtis, D. J., Patel, D. J.,
Allis, C. D., Cunningham, J. M. & Jane, S. M. (2009). PRMT5-mediated methylation of histone H4R3
recruits DNMT3A coupling histone and DNA methylation in gene silencing. Nat. Struct. Mol. Biol. 16,
304-311.
Li, H., Motamedi, M., Yip, C. K., Wang, Z., Waql, T., Patel, D. J. & Moazed, D. (2009), An alpha motif of
Tas3 C-terminus mediated RITS cis-spreading and promotes heterochromatin gene silencing. Mol. Cell
34, 155-167.
2010
Wang, Z., Song, J., Milne, T. A., Wang, G. G., Li, H., Allis, C. D. & Patel, D. J. (2010). Pro isomerization
in MLL1 PHD3-Bromo cassette connects H3K4me3 readout to CyP33 and HDAC-mediated repression.
Cell 141, 1183-1194.
Tsai, W-W., Wang, Z., Yiu, T. T., Akdemir, K. C., Xia, W., Winter, S., Tsai, C-Y., Shi, X., Schwarzer, D.,
Plunkett, W., Aronow, B., Gozani, O., Fischle, W., Hung, M. C., Patel, D. J. & Barton, M. C. (2010).
TRIM24 links recognition of a non-canonical histone signature to breast cancer. Nature 468, 927-932.
Rechkoblit, O., Kolbanovskiy, A., Malinina, L., Geacintov, N. E., Broyde, S. & Patel, D. J. (2010). Y-family
polymerase-facilitated mechanism of error-free bypass and semi-targeted mutagenic processing of an
aromatic amine lesion. Nat. Struct. Mol. Biol. 17, 379-388.
Wang, Y., Ludwig, J., Sheng, G., Juranek, S., Micura, R., Tuschl, T., Hartmann, G. & Patel, D. J. (2010).
Structural and functional insights into 5’-ppp-dsRNA pattern recognition by the innate immune receptor
RIG-I. Nat. Struct. Mol. Biol. 17, 781-787.
Huang, L., Serganov, A. & Patel, D. J. (2010). Structural insights into ligand recognition by a sensing
domain of the cooperative glycine riboswitch. Mol. Cell 40, 774-786.
2011
Song, J., Rechkoblit, O., Bestor, T. H. & Patel, D. J. (2011). Structure of DNMT1-DNA complex reveals a
role for autoinhibition in maintenance DNA methylation. Science 331, 1036-1040.
Ruthenburg, A., Li, H., Milne, T., Dou, Y., McGinty, R. K., Yuen, M., Muir, T. W., Patel, D. J. & Allis, C. D.
(2011). Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent
interactions. Cell 145, 692-706.
Weinberg, D., Nakanishi, K., Patel, D. J. & Bartel, D. P. (2011). The inside-out mechanism of Dicers from
budding yeasts. Cell 146, 262-276.
Xi, Q., Wang, Z., Zaromytidou, A., Zhang, X. H., Chow-Tsang, L-F., Liu, J. X., Kim, H., Monova-
Todorova, K., Kaartinen, V., Studer, L., Mark, W., Patel, D. J. & Massague, J. (2011). A poised chromatin
platform for Smad access to master regulators. Cell 147, 1511-1524.
Park, J. E., Heo, I., Tian, Y., Shimanshu, D., Chang, H., Jee, D., Patel, D. J. & Kim, V. N. (2011). Dicer
recognizes the 5’-end of RNA for efficient and accurate cleavage. Nature 475, 201-205.
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Pikovskaya, O., Polonskkaya, A., Patel, D. J. & Serganov, A. (2011). Structural principles of nucleoside
selectivity in a 2’-deoxyguanosine. Nat. Chem. Biol. 7, 748-755.
Rajakumara, E., Wang, Z., Ma, H., Hu, L., Chen, H., Lin, Y., Guo R., Wu, F., Li, H., Lan, F., Shi, Y., Xu,
Y., Patel, D. J. & Shi, Y. (2011a). PHD finger recognition of unmodified histone H3R2 links UHRF1 to
regulation of euchromatic gene expression. Mol Cell 43, 275-284.
Rajakumara, E., Law, J. A., Shimanshu, D. K., Voigt, P., Johnson, L. M., Reinberg, D., Patel, D. J. &
Jacobsen, S. E. (2011b). A dual flip out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA
domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev. 25, 137-152.
Tian, Y., Simanshu, D. K., Ascano, M., Daiz-Avalos, R., Park, A. Y., Juranek, S. A., Rice, W. J., Yin, Q.,
Robinson, C. C., Tuechl, T. & Patel, D. J. (2011). Multimeric assembly and biochemical characterization
of the Trax-translin endonuclease complex. Nat. Struct. Mol. Biol. 18, 658-664.
Iwase, S., Xiang, B., Ghosh, S., Ren, T., Lewis, P. W., Cochrane, J. C., Allis, C. D., Picketts, D. J., Patel,
D. J., Li, H. & Shi, Y. (2011). ATRX links atypical histone methylation recognition mechanisms to human
mental retardation syndrome. Nat. Struct. Mol. Biol. 18, 769-776.
Phan, A. T., Kuryavyi, V., Darnell, J. C., Serganov, A., Majumdar, A., Raslin, T., Polonskaia, A., Chen,
C., Clain, D., Darnell, R. B. & Patel, D. J. (2011). Structure-function studies of FMRP RGG peptide
recognition of an RNA duplex-quadruplex junction. Nat. Struct. Mol. Biol. 18, 796-804.
Teplova, M., Wohlbold, L., Kim, N. Y., Izaurralde, E. & Patel, D. J. (2011). Structure-function studies of
nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat. Struct. Mol.Biol. 18, 990-998.

2012
Song, J., Teplova, M., Ishibe-Murakami, S. & Patel, D. J. (2012). Structural principles underlying DNMT1-
mediated DNA methylation. Science 335, 709-712.
Kuo, A. J., Song, J., Cheung, P., Ishibe-Murakami, S., Yamazoe, S., Chen, J., Patel, D. J. & Gozani, O.
(2012). ORC1 BAH domain links dimethylation of H4K20 to DNA replication licensing and Meier-Gorlin
syndrome. Nature 484, 115-119.
Ren, A., Rajashankar, K. & Patel, D. J. (2012). Structure of the fluoride riboswitch reveals F- ion
encapsulation by Mg2+ ions and RNA phosphates. Nature 486, 85-89.
Nakanishi, K., Weinberg, D. E., Bartel, D. P. & Patel, D. J. (2012). Structure of yeast Argonaute with guide RNA. Nature 486, 368-374.

Kruidenier, L., Chung, C., Cheng, Z., Liddle, J., Bantscheff, M., Bountra, C., Bridges, A., Che, K., Diallo,
H., Eberhard, D., Hutchinson, S., Joberty, G., Jones, E., Katso, R., Leveridge, M., Mosley, J., Rowland, P., Ramirez-Molina, C., Schofield, C. J., Sheppard, R., Smith, J. E., Swales, C., Tanner, R., Thomas, P.,
Tumber, A., Drewes, G., Oppermann, U., Patel, D. J., Lee, K., & Wilson, W. (2012). A selective H3K27
demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408.
Du, J., Zhong, X., Barnatavichute, Y. V., Stroud, H., Feng, S., Caro, E., Vashisht, A. A., Terragni, J., Tu,
J., Hetzel, J., Wohlschlegel, J. A., Pradhan, S., Patel, D. J. & Jacobsen, S. E. (2012). Dual binding of
chromomethylase BAH and chromo domains to H3K9me2-containing nucleosomes in the targeting of
DNA methylation. Cell 157, 167-180.
Elsasser, S. J., Huang, H., Lewis, P. W., Allis, C. D. & Patel, D. J. (2012). DAXX histone chaperone
envelops an H3.3/H4 dimer for H3.3-specific recognition. Nature 491, 560-565.
2013
Oh, Y-S., Gao, P., Lee, K., Ceglia, I., Zhang, X., Ahn, J-H., Chait, B. T., Patel, D. J., Kim, Y. &
Greengard, P. (2013). SMARCA3, a chromatin remodeling factor, is required for p11-dependent
antidepressant action. Cell 152, 841-843.
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Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A., Jones, R. A.,
Hartmann, G., Tuschl, T. and Patel, D. J. (2013a). Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second
messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107.
Gao, P., Ascano, M., Zillinger, T., Wang, Y., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones,
R., Deng, L., Hartmann, G., Barchet, W., Tuschl, T. and Patel, D.J. (2013b). Structure-function analysis
of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by DMXAA. Cell 154, 748-762.
Shen, J., Xia, Y., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S-O., Du, Y., Wang, Y., Chang, W-C.,
Chen, C-H., Hsu, J. L., Lam, Y. C., James, B. P., Liu, C-G., Liu, X., Patel, D. J. & Hung, M. C. (2013).
EGFR modulates miRNA maturation in response to hypoxia through phosphorylation of Ago2. Nature
497, 383-387.
Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Strahl, B. D., Patel, D. J. & Jacobsen, S. E.
(2013). Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature 498,
385-389.
Sun, X-J., Wang, Z., Wang, L., Jiang, Y., Chen, W-Y., Melnick, A., Patel, D. J., Nimer, S. D. & Roeder, R.
G. (2013). A stable transcription factor complex nucleated by dimeric AML1-ETO controls
leukemogenesis. Nature 500, 93-97.
Simanshu, D. K., Kamlekar, R. K., Wijesinghe, D. S., Zou, X., Zhai, X., Mishra, S. K., Molotkovsky, J. G.,
Malinina, L., Hincliffe, E. H., Chalfant, C. E., Brown, R. E. & Patel, D. J. (2013a). Nonvesicular trafficking
by ceramide-1-phosphate transfer protein regulates eicosanoid production. Nature 500, 463-467.
Patel, D. J. and Wang, Z. (2013). A structural perspective of readout of epigenetic posttranslational
modifications. Ann. Rev. Biochem. 82, 81-118.
Dai, Q., Ren, A., Westholm, J. O., Serganov, A., Patel, D. J. & Lai, E. C. (2013). The BEN domain is a
novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes
Dev. 27, 602-614.
Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T. and Patel, D. J. (2013). Structure-function
studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 27, 928-
940.
Cai, L., Rothbart, S. B., Lu, R., Xu, B., Tripathy, A., Chen, W-Y., Zheng, D., Patel, D. J., Allis, C. D.,
Strahl, B. D., Song, J. & Wang, G. (2013). An H3K36me3-containing Tudor motif of polycomb-like
proteins mediates PRC2 complex targeting. Mol. Cell 49, 571-582.
Simanshu, D. K., Yamaguchi, Y., Park, J-H., Inouye, M. and Patel, D. J. (2013b). Structural insights into
mRNA recognition by toxin MazF and its regulation by antitoxin MazE in B. subtilis. Mol. Cell 52, 447-
458.
Nakanishi, K., Ascano, M., Gogakos, T., Ishibi-Murakami, S., Serganov, A. A., Briskin, D., Morozov, P.,
Tuschl, T. and Patel, D. J. (2013). Eukaryote-specific insertion elements control human ARGONAUTE
slicer activity. Cell Reports 3, 1893-1900.
2014
Johnson, L. M., Du, J., Chodavarapu, R. K., Feng, S., Zhong, X., Hale, C. J., Marson, G., Segal, D. J.,
Pellergrini, M., Patel, D. J. and Jacobsen, S. E. (2014). SRA/SET domain proteins link RNA polymerase
V binding to DNA methylation. Nature in press.
Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Wang, Y., Patel, D. J., Berenguer, J.,
Brouns, S. J. and van der Oost, J. (2014). DNA-guided DNA interference by prokaryotic Argonaute.
Nature in press.
Noh, K. M., Wang, H., Jiang, Y., Wenderski, W., Li, C., Dewell, S., Zheng, D., Melnick, A, Patel, D. J., Li,
H. and Allis, C. D. (2014). Engineered Dnmt3a reveals a critical role of epigenetic organization at CpG
islands. Nature under revision.

26篇Nature文章，2004-2014区区十年，2.6篇Nature/年！其他的Nature子刊，Science和Cell等等还不算！

这对于追捧CNS的中国科学界，这是不是会被热捧为“天人”？

他现在实验室的主要研究人员基本上全是中国人。估计这些中国人回国后，会对中国科学界带来更为深重的“灾难”，如果一如既往，赢者通吃，那么试看将来的中国科学，必将是晶体学-X射线衍射-结构生物学的天下！清华同仁会不会有紧迫感？