维生素E促进大脑健康的神经学分析

   前言

   既往的很多临床研究都表明，抗氧化剂维生素E对于治疗老年性痴呆症无效，且对于轻度认知功能障碍亦无效。然而，2014年发表在JAMA杂志上的一项临床试验表明，维生素E对于中重度老年性痴呆是可以改善认知功能的，且疗效和美金刚相似，而二者联用不增强效果。

   那到底补充维生素E是否可以促进大脑健康，甚至预防和治疗大脑疾病呢？今天我们就来看看相关的研究。

维生素E和大脑结构和大脑功能

1. 维生素E缺乏可以引起大脑认知功能障碍

   Long-Term Vitamin E-Deficient Mice Exhibit Cognitive Dysfunction via Elevation of Brain Oxidation.

2. 维生素E帮助大脑抵抗衰老过程中的氧化应激

   Aging brain: prevention of oxidative stress by vitamin E and exercise.

3. 维生素E可以提高大脑海马和额叶皮层的线粒体功能

   High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging.

4. 饮食中维生素E不足可能会增加焦虑性行为

   Dietary vitamin E deficiency increases anxiety-like behavior in juvenile and adult rats.

5. 维生素E缺乏可能会减少Aβ的清除

   Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances frombrain and blood in a mouse model of Alzheimer disease.

维生素E和大脑疾病

1. 维生素E用于治疗AD和认知功能障碍的研究证据尚不充分

   Effects of vitamin E on cognitive performance during ageing and in Alzheimer's disease.

2. 维生素E可以防止由高脂肪和高糖饮食引起的记忆力损害

   Vitamin E prevents high-fat high-carbohydrates diet-induced memory impairment: the role of oxidative stress.

3. 维生素E对于预防脑胶质瘤无效

   Vitamin E intake is not associated with glioma risk: evidence from a meta-analysis.

4. 维生素E可能促进糖尿病大鼠的学习记忆能力

   Vitamin E improves learning performance and changes the expression of nitric oxide-producing neurons in the brains of diabetic rats.

5. 维生素E可以防止慢性睡眠缺乏引起的记忆损害

   The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment: the role of oxidative stress.

6. 维生素E可能有助于治疗脑损伤

   Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.

7. 维生素E可能有助于治疗脑缺血损伤

   Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1.

   Protective effect of vitamin E against focal brain ischemia and neuronal death through induction of target genes of hypoxia-inducible factor-1.

8. 维生素E有助于治疗大脑白质损伤

   Clinical investigation of the protective effects of palm vitamin E tocotrienols on brain white matter.

9. 维生素E能够预防缺血性脑卒中

   Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials.

10. 维生素E可能有助于治疗神经变性

    Neuroprotective properties of the natural vitamin E alpha-tocotrienol.

11. 维生素E延缓大脑衰老

    Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice.