Nature最新一篇文章"8个假丝酵母的有性生殖和致病性的演化":Evolution of pathogenicity and sexual reproduction in eight Candida genomes. 摘要：

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome
sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant
expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with
virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination
events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include
major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/a2 cell
identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of
the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose
elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.

这篇文章出来后，可以做很多的工作，比如比较基因组学研究：基因组演化，基因家族演化等，特别是比较研究某些基因的演化机制，可能得到很多以前没有发现的规律，每个规律的得到就是文章，赶快挖掘吧。暑假有时间好好琢磨下，有没有感兴趣的呢？

基因组官方网站：http://www.broad.mit.edu/annotation/genome/candida_group/MultiHome.html