A three-dimensionally woven biomaterial scaffold consisting of multiple layers of resorbable fiber bundles woven into a porous structure. The scaffold is seeded with cells in order to accelerate natural cartilage repair and growth. Frank Moutos and Farshid Guilak, Duke University Medical Center, Durham, NC
This micrograph shows cells called myoblasts attached to spherical microcarriers, which allow the growth of adult stem cells (green) that have been isolated from skeletal muscle.Douglas B. Cowan, Harvard Medical School
Closely related electric fish species from the Okano River of Gabon shown along with a recording of its electric organ discharge. Matthew E. Arnegard, Derrick J. Zwickl, Ying Lu, and Harold H. Zakon
This image shows foot processes of genetically labeled cells (red) covering walls of capillaries (green) in a kidney of a mouse. Ivica Grgic, Craig R. Brooks, Andreas F. Hofmeister, Vanesa Bijol, Joseph V. Bonventre, and Benjamin D. Humphreys
Tissue from a colon biopsy stained for the single IgG IL-1-related receptor (Sigirr) and other cellular components is shown. Therapeutic targeting of Sigirr could be useful in the treatment of inflammatory bowel disease or other inflammatory disorders of the gastrointestinal tract. Mohammed Khan, Theodore S. Steiner, Ho Pan Sham, Kirk S. Bergstrom, Jingtian T. Huang, Kiran Assi, Bill Salh, Isabella T. Tai, Xiaoxia Li, and Bruce A. Vallance
The image features nerve fibers (blue) and their attendant microglia (green), the cells responsible for immune defense in the central nervous system, as the fibers converge to form the optic nerve in a mouse retina. Alejandra Bosco and Monica L. Vetter, University of Utah, Salt Lake City, UT
(Top) A limb from a transgenic, embryonic mouse, showing well established musculoskeletal and nervous systems. (Bottom) A model, derived from the upper panel image, showing muscles, tendons, bones, and nerves. A. Kelsey Lewis, Yong Wan, Mary Colasanto, Mark van Langeveld, Ronen Schweitzer, Charles D. Hansen, and Gabrielle Kardon
This butterfly shaped figure is an image of a rat spinal cord showing the distribution of three types of glutamate and nitric oxide synthesizing enzymes. Li-Hsien Lin, University of Iowa
This image depicts stem cells (green) and neuronal nuclei (red) in the hippocampus, a brain structure crucial for cognitive function. Grigori Enikolopov and Ann-Shyn Chiang
This image shows a culture of differentiated neuronal cells (green) and neural progenitor cells (red), with the nuclei of the cells in blue. Rakesh Karmacharya, Stuart L. Schreiber, and Stephen J. Haggarty, Harvard University