▲ Vol 04 Issue 05 | September, 2022

Ultrathin triphenylamine–perylene diimide polymer with D–A structure for photocatalytic oxidation of N-heterocycles using ambient air

Hanjie Zhang, Kunyi Yu, Zhaohui Wu, Yongfa Zhu

An ultrathin porous triphenylamine–perylene diimide (PDI) polymer photocatalyst with photooxidative ability was prepared. Triphenylamine–PDI oxidizes 1,2,3,4-tetrahydroisoquinoline to 3,4-dihydroisoquinoline with a yield of 84% and selectivity of 92% under the following conditions: room temperature, ambient air, aqueous solution and 420 nm irradiation. The yield was 62% higher than that of mesoporous g-C3N4 and 72% higher than that of self-assembled PDI. The high yield and enhanced catalytic activity of the triphenylamine–PDI were attributed to the introduction of the electron-donating triphenylamine motif into PDI, thereby forming a donor–acceptor structure, which greatly promotes the separation of photogenerated charges. In addition, the triphenylamine–PDI with high crystallinity of was conducive to fast charge transport. Triphenylamine–PDI was also applicable to other N-heterocyclic substrates. Moreover, using aqueous media and air as oxidant are consistent with green chemistry, and the photocatalyst can be recycled after the reaction.

https://onlinelibrary.wiley.com/doi/10.1002/eom2.12215

▲ Vol 40  Issue 09 | September, 2022

Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient Tumor Targeted siRNA Delivery

Rong-Ze Wang, Si Huang, Qiao-Yun Zhang, Xing-Su Yu, Ke-Ze Hong, Jian-Rong Cao, Hong Xiao, Yong Wang & Xin-Tao Shuai 

RNA interference (RNAi), known for the highly efficient targeted gene silencing, has been demonstrated to be a promising means for cancer treatment. Meanwhile, an effective approach for siRNA delivery is urgently needed to meet the needs for its clinical application. Herein, we constructed a polymeric vector labeled with superparamagnetic iron oxide (SPIO) for magnetic resonance imaging (MRI) visible siRNA delivery. EGFR antibody was also modified to the surface of nanodrug to enhance the delivery effect. Our results showed that the vector exhibited great siRNA complexation ability and mediated an increased endocytosis of siRNA without obvious cytotoxicity. Besides, both in vitro and in vivo studies evidenced the vector could effectively deliver siRNA into tumor cells, exert highly interfering effect, and show potent MR imaging capacity. The study provides a promising MRI-visible and EGFR targeting delivery system to improve RNAi efficacy for cancer therapy.

https://link.springer.com/journal/10118/volumes-and-issue‍s/40-9

▲ Vol 02  Issue 03 | September, 2022

A decoupling three-dimensional motion control algorithm for spherical underwater robot

Pengxiao Bao, Yao Hu, Liwei Shi, Shuxiang Guo, Zhengyu Li

Underwater spherical robots are good assistants for ocean exploration, where motion control algorithms play a vital role. Conventional motion control algorithms cannot eliminate the coupling relationship between various motion directions, which will cause the motion control of various directions to interfere with one other and significantly affect the control effect. This study proposes a new decoupling motion control algorithm based on the robot attitude calculation for an underwater spherical robot designed for offshore, shallow water, and narrow terrain. The proposed method uses four fuzzy proportional–integral–derivative (PID) controllers to independently control the robot’s movement in all directions. Experiments show that the motion control algorithm proposed in this study can significantly improve the flexibility and accuracy of the movement of underwater spherical robots.

https://www.sciencedirect.com/science/article/pii/S2667379722000274

▲ Issue 303 | 01 September, 2022

Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response

Hao Zeng, Ting Pan, Meiling Zhan, Renaguli Hailiwu, Baolin Liu, Hua Yang & Ping Li

Endothelial-to-mesenchymal transition (EndoMT), the process wherein endothelial cells lose endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical contributor to cardiac fibrosis. The phenotypic plasticity of endothelial cells can be intricately shaped by alteration of metabolic pathways, but how endothelial cells adjust cellular metabolism to drive EndoMT is incompletely understood. Here, we identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) as a critical driver of EndoMT via triggering abnormal glycolysis and compromising mitochondrial respiration. Pharmacological suppression of PFKFB3 with salvianolic acid C (SAC), a phenolic compound derived from Salvia miltiorrhiza, attenuates EndoMT and fibrotic response. PFKFB3-haplodeficiency recapitulates the anti-EndoMT effect of SAC while PFKFB3-overexpression augments the magnitude of EndoMT and exacerbates cardiac fibrosis. Mechanistically, PFKFB3-driven glycolysis compromises cytoplasmic nicotinamide adenine dinucleotide phosphate (reduced form, NADPH) production via hijacking glucose flux from pentose phosphate pathway. Efflux of mitochondrial NADPH through isocitrate/α-ketoglutarate shuttle replenishes cytoplasmic NADPH pool but meanwhile impairs mitochondrial respiration by hampering mitochondrial iron-sulfur cluster biosynthesis. SAC disrupts PFKFB3 stability by accelerating its degradation and thus maintains metabolic homeostasis in endothelial cells, underlying its anti-EndoMT effects. These findings for the first time identify the critical role of PFKFB3 in triggering EndoMT by driving abnormal glycolysis in endothelial cells, and also highlight the therapeutic potential for pharmacological intervention of PFKFB3 (with SAC or other PFKFB3 inhibitors) to combat EndoMT-associated fibrotic responses via metabolic regulation.

https://www.nature.com/articles/s41392-022-01097-6

▲Vol 03  Issue 09 | 07 September, 2022

Conceptual Ultraviolet-C Light Source Based on Up-Conversion Luminescence

Xiyu Zhao, Feng Liu, Tingxing Shi, Huajun Wu, Liangliang Zhang, Jiahua Zhang, Xiao-jun Wang, Yichun Liu

Up-Conversion Luminescence

Feng Liu, Jiahua Zhang and co-workers explore an innovative way of using visible light for disinfection application by introducing a transmissive remote phosphor-converted light source using a phosphor composite film, which gives ultraviolet-C emission upon excitation with blue lasers. More information can be found in article number 2200106.

https://onlinelibrary.wiley.com/doi/10.1002/adpr.202270031

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。