▲ Vol 05 Issue 09 | 07 September, 2022

Transparent and flexible structurally colored biological nanofiber films for visual gas detection

Mengjiao Shi, Lulu Bai, Dehui Wan, Jin Chang, Qing Li, Haipeng Yu, Shouxin Liu, Tong Wei, Wenshuai Chen, Zhuangjun Fan

Structurally colored films hold promise as cheap platforms for use in visual detection. However, achieving accurate stimuli-responsive functions that can be distinguished by the naked eye in a single thin, robust, and practically useful material remains a challenge. Herein, we demonstrate flexible and self-standing structurally colored films fabricated by filtrating sustainable hydrophilic nanofibrillated cellulose through a porous hydrophobic membrane, followed by natural drying. 480–644 nm thick and composed of densely packed, high-aspect-ratio nanofibers entangled in web-like structures, the films are transparent, tailorable into a variety of shapes, and easily foldable. They exhibit iridescence owing to thin-film interference and reversibly change color in seconds when exposed to various moist gases and liquids. We validate the visual gas-detection capabilities of the films by measuring the ethanol concentration in the breath of an inebriated participant and envisage that these materials will find use in automated and broad-spectrum gas-detection devices.

https://www.cell.com/matter/fulltext/S2590-2385(22)00291-0#%20

▲ Vol 09 Issue 26 | 15 September, 2022

Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment 

Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang,Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

Small Activating RNA Modulation

In article number 2200562, Ling Peng, Leo Tsz On Lee, and co-workers, report for the first time that small activating RNA (saRNA) delivered by amphiphilic dendrimer can effectively modulate a G protein-coupled receptors (GPCR), Mas receptor, for cancer treatment. This project provides not only a new strategy for cancer therapy, but also a new avenue to address undruggable GPCRs.

https://onlinelibrary.wiley.com/doi/10.1002/advs.202270162

▲ Vol 147 Issue 18 | 21 September, 2022

Fluorescence detection of the human angiotensinogen protein by the G-quadruplex aptamer

Hui Xi, Hanlin Jiang, Mario Juhas and Yang Zhang

Noncanonical G-quadruplex nucleic acid structures can be used as probes in biosensors for the detection of metal ions, proteins and nucleic acids. Angiotensinogen (AGT) is a glycosylated globulin found in serum, which can regulate blood pressure and body fluid homeostasis. AGT is an important part of the renin–angiotensin system (RAS) and can be potentially used as a biomarker of diseases with RAS alterations. G-quadruplex based biosensors can detect targets with high accuracy and speed and low cost. Employing the magnetic bead enrichment method we constructed a reliable and efficient fluorescent biosensor platform for G-quadruplex based detection of the human AGT protein. The primary antibody in our biosensor is recognized by fluorescently labeled secondary antibodies, which leads to the detection of AGT captured by the G-quadruplex aptamer coupled magnetic beads. This G-quadruplex based fluorescent biosensor designed with a detection limit of 5 × 10–5 mg mL−1 was used for the successful detection of AGT at the cellular level. Our G-quadruplex based fluorescent biosensor will contribute to the more reliable and efficient detection of AGT.

https://pubs.rsc.org/en/content/articlelanding/2022/an/d2an01057g

▲ Vol 05 Issue 03 | 25 September, 2022

Enabling Argyrodite Sulfides as Superb Solid-State Electrolyte with Remarkable Interfacial Stability Against Electrodes

Hongjie Xu, Guoqin Cao, Yonglong Shen, Yuran Yu, Junhua Hu, Zhuo Wang, Guosheng Shao

While argyrodite sulfides are getting more and more attention as highly promising solid-state electrolytes (SSEs) for solid batteries, they also suffer from the typical sulfide setbacks such as poor electrochemical compatibility with Li anode and high-voltage cathodes and serious sensitivity to humid air, which hinders their practical applications. Herein, we have devised an effective strategy to overcome these challenging shortcomings through modification of chalcogen chemistry under the guidance of theoretical modeling. The resultant Li6.25PS4O1.25Cl0.75 delivered excellent electrochemical compatibility with both pure Li anode and high-voltage LiCoO2 cathode, without compromising the superb ionic conductivity of the pristine sulfide. Furthermore, the current SSE also exhibited highly improved stability to oxygen and humidity, with further advantage being more insulating to electrons. The remarkably enhanced compatibility with electrodes is attributed to in situ formation of helpful electrolyte–electrode interphases. The formation of in situ anode–electrolyte interphase (AEI) enabled stable Li plating/stripping in the Li|Li6.25PS4O1.25Cl0.75|Li symmetric cells at a high current density up to 1 mA cm−2 over 200 h and 2 mA cm−2 for another 100 h. The in situ amorphous nano-film cathode–electrolyte interphase (CEI) facilitated protection of the SSE from decomposition at elevated voltage. Consequently, the synergistic effect of AEI and CEI helped the LiCoO2|Li6.25PS4O1.25Cl0.75|Li full-battery cell to achieve markedly better cycling stability than that using the pristine Li6PS5Cl as SSE, at a high area loading of the active cathode material (4 mg cm−2) in type-2032 coin cells. This work is to add a desirable SSE in the argyrodite sulfide family, so that high-performance solid battery cells could be fabricated without the usual need of strict control of the ambient atmosphere.

https://onlinelibrary.wiley.com/doi/10.1002/eem2.12282

▲ Vol 34 Issue 39 | 28 September, 2022

Edge-Site Engineering of Defective Fe–N4 Nanozymes with Boosted Catalase-Like Performance for Retinal Vasculopathies

Ruofei Zhang, Bai Xue, Yanhong Tao, Hanqing Zhao, Zixia Zhang, Xiaonan Wang, Xinyao Zhou, Bing Jiang, Zhenglin Yang, Xiyun Yan, Kelong Fan

High-Performance Nanozymes

In article number 2205324, Zhenglin Yang, Xiyun Yan, Kelong Fan, and co-workers report a high-performance catalase-like iron single-atom nanozyme prepared by edge-site engineering. Hierarchical mesoporous and edge-hosted atomic sites are formed during the pyrolysis process, enabling efficient catalytic decomposition of H2O2 into O2 and H2O. Based on the catalase-like activity, effective treatment of retinal vasculopathies is realized by intravitreal administration of the nanozyme.

https://onlinelibrary.wiley.com/doi/10.1002/adma.202270275

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。