2024年7月10日，Royal Society of Chemistry 旗下知名期刊《Organic Chemistry Frontiers》在线发表了云南师范大学职业技术教育学院王永超副教授和昆明理工大学余富朝教授课题组合作的最新研究成果《Selective synthesis of pyridazine-fused chromones and 3-pyridazinyl chromones through intermolecular chromone annulation of o-hydroxyphenylenaminones with aryldiazonium salts》.昆明理工大学生命科学与技术学院为第一完成单位，余富朝教授、夏雪山教授和董书维副教授为通讯作者，云南师范大学职业技术教育学院王永超副教授为共同通讯作者。

https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo00677a

Abstract

Intramolecular chromone annulations of o-hydroxyphenylenaminones (o-HPEs) with a variety of C–H bond functionalization precursors have attracted much attention and become some of the most straightforward and efficient approaches for the rapid assembly of structurally diverse chromone compounds. However, the intermolecular chromone annulation reaction has not yet been developed. Herein, we report an unprecedented metal-free, chemodivergent and skeleton-controllable annulation reaction of o-HPEs with aryldiazonium salts. This protocol features a new intermolecular chromone annulation strategy for the divergent synthesis of pyridazine-fused chromones and 3-pyridazinyl chromones via adjusting the reaction temperature. Moreover, the pyridazine-fused chromones exhibit promising high antiviral activity against human coronavirus OC43 (HCoV-OC43), with higher safety than the reference drug (Arbidol), indicating that the intermolecular chromone annulation methodology might provide assistance in drug discovery.

扩展阅读：

云师大职业技术教育学院王永超副教授在《Organic Letters》发表文章最新研究文章

云师大职业技术教育学院王永超副教授在《Organic Chemistry Frontiers》发表文章最新研究文章

云师大职业技术教育学院王永超副教授在《Organic Letters》发表文章最新研究文章

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