2024年5月21日，Royal Society of Chemistry 旗下知名期刊《Organic Chemistry Frontiers》在线发表了云南师范大学职业技术教育学院王永超副教授最新研究成果《Selective synthesis of pyridazin-fused chromones and 3-pyridazinyl chromones through intermolecular chromone annulation of o-hydroxyphenylenaminones with aryldiazonium salts》.云南师范大学职业技术教育学院王永超副教授为共同通讯作者。

Abstract

Intramolecular chromone annulations of o-hydroxyphenylenaminones (o-HPEs) with a variety of C-H bond functionalization precursors have attracted much attention and become one of the most straightforward and efficient approaches for the rapid assembly of structurally diverse chromone compounds. However, the intermolecular chromone annulation reaction was not yet developed. Herein, we report an unprecedented metal-free-catalyzed, chemodivergent and skeleton-controllable annulation reactions of o-HPEs with aryldiazonium salts. This protocol is featured by a new intermolecular chromone annulation strategy for the divergent synthesis of pyridazin-fused chromones via adjusting the reaction temperature. Moreover, the pyridazin-fused chromones exhibits promising high antiviral activity against human coronavirus OC43 (HCoV-OC43), with higher safety compared to reference drug (Arbidol), indicating that the intermolecular chromone annulation methodology might provide assistance for drug discovery.

云师大职业技术教育学院王永超副教授在《Organic Letters》发表文章最新研究文章