DRINKING too much and eating too much are both good ways of getting liver cancer. But there is a third. The disrupted circadian rhythms caused by working shifts or crossing time zones also seem to induce the disease. Precisely how and why meddling with day and night cycles has such a dire effect on the liver remains an enigma, but a study just published in Cancer Cell by Loning Fu and David Moore at the Baylor College of Medicine, in Texas, sheds some light on the matter. Among the liver’s many jobs is making bile, a substance secreted into the intestine to break down the fats and oils in food. One of bile’s main components is bile acid, a derivative of cholesterol. Dr Fu and Dr Moore knew from