A robust mechanism for resetting juvenility during each generation in Arabidopsis

第一作者：Jian Gao

第一单位：中科院植物生理生态研究所

通讯作者：Jia-Wei Wang

 Abstarct 

背景回顾：Multicellular organisms undergo several developmental transitions during their life cycles. In contrast to animals, the plant germline is derived from adult somatic cells. As such, the juvenility of a plant must be reset in each generation. 

多细胞生物在其生命周期中会经历数个发育转变。与动物不同，植物的生殖系源自于成年个体的体细胞。正因如此，植物必需在每一个世代重置童期。

研究基础：Previous studies have demonstrated that the decline in the levels of miR156/7 with age drives plant maturation. 

先前的研究表明，miR156/7随着年龄的增加而减少驱动了植物的成熟。

主要研究：Here we show that the resetting of plant juvenility during each generation is mediated by de novo activation of MIR156/7 in Arabidopsis. 

本文中，作者发现拟南芥通过从头激活miR156/7来在每个世代重置童期。

结果1-敲除表型：Blocking this process leads to a shortened juvenile phase and premature flowering in the offspring. In particular, an Arabidopsis plant devoid of miR156/7 flowers even without formation of rosette leaves in long days. 

阻断该过程会导致子代的童期阶段缩短，开花提前。尤其是，敲除拟南芥中所有的miR156/7会导致其在长日照条件下，还未长出莲座叶直接抽薹开花。

结果2-稳健体系：Mechanistically, we find that different MIR156/7 genes are reset at different developmental stages through distinct reprogramming routes. Among these genes, MIR156A, B and C are activated de novo during sexual reproduction and embryogenesis, while MIR157A and C are reset upon seed germination. 

作者进一步的研究发现，不同的MIR156/7基因在不同的发育阶段，由不同的重编程机制进行重置。在这些基因中，MIR156A/B/C在有性生殖和胚胎发生阶段被从头激活，而MIR157A/C在种子萌发时被重置。

结论：This redundancy generates a robust reset mechanism that ensures accurate restoration of the juvenile phase in each plant generation.

这种冗余性形成了一个稳健的重置机制，以确保植物在每一个世代都能够精准恢复童期生长。

** 王佳伟 **

doi: https://doi.org/10.1038/s41477-022-01110-4

Journal: Nature Plants

Published date: March 21, 2022