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Science论文：揭开安慰剂治疗的假面一文的替代计量结果

已有 2627 次阅读 2014-10-1 13:07 |个人分类:科学计量|系统分类:科研笔记

Science：揭开安慰剂治疗的假面

对于那些安慰剂组在临床试验中出现巨大改善的疾病，尤其是疼痛、抑郁和其他精神疾病，克服假性治疗是一个现实障碍。

Kathryn Hall的早期职业生涯建立在药物，而非安慰剂上。作为一名分子生物学家，她在千年制药公司花费了两年时间识别药物靶点。2005年，她到针灸医生诊所寻找能缓解其腕管综合征的方法。“我记得自己坐在那里思考，我无法相信我在做这个。这太荒谬了。”她说。

在第一针落下时，Hall感到“非常恐怖”的刺痛感，之后，她不再有腕管综合征。Hall承认，这些针可能有生理作用。但她仍对这种可能性感到着迷：症状缓解部分由于安慰剂效应——患者从对疗法的预期中获得真实的利益。

http://news.bioon.com/article/6659581.html

Outsmarting the placebo effect

文献检索：DOI：10.1126/science.345.6203.1446

The placebo effect—real improvement brought on by the expectation of receiving treatment—can offer significant relief for patients. But a strong placebo response is problematic in clinical trials， where it makes it harder to show that a drug is effective. Based on a small study that correlates variants of a certain gene to a person's level of placebo response， a former biotech executive has formed a company around predicting who will improve most from a placebo. The gene could offer a way to reduce the size and cost of clinical trials by excluding these people. But some veterans of placebo research are skeptical that this gene will be predictive across trials and for a wide range of diseases.

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Outsmarting the placebo effect