拉尔夫·斯Ralph Marvin Steinman, born in Montreal, Canada, on January 14, 1943, is a biologist. Professor, Laboratory of Cell Physiology and Immunology, Rockefeller University, USA. In 2011, he won the Nobel Prize in Physiology or Medicine together with American scientist Bruce Beutler and Luxembourg scientist Jules Hoffman.坦曼（Ralph Marvin Steinman），1943年1月14日生于加拿大蒙特利尔，生物学家。美国洛克菲勒大学细胞生理学和免疫学实验室教授。2011年，与美国科学家布鲁斯·比尤特勒、卢森堡科学家朱尔斯·霍夫曼共同获得当年诺贝尔生理学或医学奖。

https://baike.baidu.com/item/%E6%8B%89%E5%B0%94%E5%A4%AB%C2%B7%E6%96%AF%E5%9D%A6%E6%9B%BC/4280423?fromModule=lemma_inlink

https://pubmed.ncbi.nlm.nih.gov/4573839/

summary-SteinmanRM-set (1).txt

Abstract

A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

Comment in

• Kicking off adaptive immunity: the discovery of dendritic cells.

  Katsnelson A.J Exp Med. 2006 Jul 10;203(7):1622. doi: 10.1084/jem.2037fta.PMID: 16886239 Free PMC article.

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MeSH terms

• Animals

• Cell Adhesion

• Cell Nucleus

• Cell Separation

• Cytological Techniques

• Cytoplasmic Granules

• Histocytochemistry

• Liver / cytology

• Lymph Nodes / cytology

• Lymphoid Tissue / cytology*

• Macrophages / cytology

• Mice

• Microscopy, Electron

• Microscopy, Phase-Contrast

• Mitochondria

• Peyer's Patches / cytology

• Spleen / cytology

• Thymus Gland / cytology

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