Science—— 激活不定带GABA能神经元引起暴饮暴食

Abstract

1.Optogenetic activation of ZI GABA neurons rapidly evokes binge-like eating.

2.Optogenetic activation of ZI GABA axon terminals in PVTrapidly evokes eating with preference for high-fat food.

3.Binge-like eating evoked by optogenetic activation of ZI GABA axon terminals produces rapid increase in body weight and shows positive hedonic association.

4.Direct and indirect activation of glutamatergic PVT neurons postsynaptic to ZI axons inhibits food intake.