他写了一个帖子Organic Chemistry: A Lack of Challenges?（有机化学，缺乏挑战？）

有机化学发展到今天，每人都在JACS，ACIE上灌水，好似有机化学都很精彩，一个复杂的分子可以很精确的合成出来，难道有机化学没挑战么？恰恰不是，而是挑战太大。。

I worry a lot about organic chemistry, about the state of the discipline. I worry about the relative lack of grand challenges, and that most academic work is highly incremental and, worse, almost entirely the result of screening rather than design. There is still so little predictive power (at least in academia) in drug or catalyst discovery. I have a theory that the reason we're so brutal with each other in paper and grant refereeing is because we're essentially dogs under the table fighting for scraps.（我担心有机化学很多，尤其是学科目前的状况，我担心有机化学重大挑战相对缺乏，但是学术论文数量在迅速增加，可笑的是，几乎完全是在筛选结果， 而并非基于化学原理的设计。我们对于发现新药或催化剂的预测力如此有限（至少在学术界）。我认为，在审稿论文和基金判定时，我们却互相瞧不起对方的工作或计划，恰恰说明我们就像饭桌下面乞讨残羹冷饭的狗那样可怜。博主译）

There are big exceptions, which make me excited to be a scientist. There's usually something in Nature Chemistry that has the wow factor, for example. They're just so rare. . .