（午餐1瓶，晚餐2瓶的意大利酒是必备的）

（第一天的晚上晚餐10点结束，会议请来本地歌手来阳台平台演唱歌曲还可以群魔乱舞，disco，太累了，拍了张照片就回房间休息了）

（每天早餐新鲜烤制的牛角包配上现做的意大利咖啡卡普提诺和新鲜水果，面对大海开吃，美哉）

Session 1: Metals

Time Title PresenterAffiliation Page

8:30-09:00 K1- Stiffness ofmetals, alloys and components N. Hort Helmholtz-Zentrum Geesthacht, GermanyMet-1

09:00-09:20

Stiffness

Elastic moduli

Stiffness of a component depends on E , geometry: cross section—areamoment of inertia

Can E be tailored? Yes

Amount of solute atoms

Intermetallic phases

Geometry

O1- Cold-drawn ZM21 and WE43 wires exhibit exceptionalstrength and ductility

A.J. Griebel

Fort Wayne Metals ResearchProducts

Corp., USA

Why cold-drawn wire?

Efficient, scalable process

Property improvements: strength gain; grain refinement; surface finish

Versatility: 20mm-12micrometer, flat/shaped; stranghtening;stranding/cabling

Wire in Medicine

Bio-counductors, guidewire…

Wire in absorbable medicine

Orthopedic,,…

Mg alloy wire

Desirable but difficult

Very limited commercial availability

Recent academic work

Investigate, possible cold reduction, working harden on ZA21 and WE43alloys

Maximum reduction

WE43 drawn to 71 micrometer from 510 micrometer

Work hardening

WE43 UTS 200MPa---285MPa

265MPa---565MPa  when Ts=3.9

Thermal response

150, 175,200, 225, 250 degree C annealing WE43 Ts=2.3 350 degree C 500MPawith high ductility

加上aging, 强度可到600多MPa 并有合适的延伸率

有人评论：他以前研究过WE43的冷拔丝没有挤压丝的性能好，尤其是疲劳和应力腐蚀疲劳。

Met-2

09:20-09:40 O2- In situsynchrotron radiation diffraction during solidification of Mg15Gd G. SzakácsHelmholtz-Zentrum Geesthacht, Germany Met-3

Mg+Mg3Gd+Mg5Gd eutectic during solidification

Mg3Gd 在561度的in situ XRD观察到，随后变为Mg5Gd

09:40-10:00 O3- Mechanical andcorrosion properties of UFG Mg alloys E. Mostaed Politecnico di Milano, ItalyMet-4

ZK60

ECAP

4 passes at 250, 200 and 150 degreeC

Average grain size 0.6 micrometer

UFG 断口界面与拉伸棒呈45度的延性，而普通的是垂直的脆性

UFG sample shows more uniform corrosion morphology on the sureface.

Superplastic ductility, tensile test at 200 degreeC at a strain rate of10-3S-1

Remarkable elongation of about 300% achieved for UFG sample.

10:00-10:20 O4- In vitro studyon novel Zn-ZnO composites with tunable degradation rate Y.F. Zheng PekingUniversity, China Met-5

10:50-11:10

O5- Experiments and numerical simulations to evaluatepeeling properties of polymeric coatings for degradable Mg stents

F. Migliavacca Politecnico diMilano, Italy Met-6

Suitable mechanical properties

PCL dipping machine

Thickness variation with dip process

When peeling angle is 90 degrees

Very low adhesion force

11:10-11:30

O6- Binder-jetting 3D printing (3DP) of customized patientspecific

craniofacial scaffolds ofFe-Mn based alloys

P.N. Kumta University ofPittsburgh, USA Met-7

Needs for patient specific scaffold

High energy mechanical alloying

Fe-Mn-Me powder <44micometer

Spherical pure Fe powder<10 micrometer

Fe-Mn

Exone’s RxD Binder-jetting printer

Sinstering at 1200 degree C 3hours

11:30-11:35

SOP1- Effect of Sc addition on microstructure, mechanicalproperties and in

vitro corrosion behaviour ofbiodegradable Mg-1.5Zn-0.6Zr (ZK21) alloy

T. Li Peking University,China Met-8

0.2, 0.5, 1.0 Sc

11:35-11:40 SOP2- Evaluation ofmagnesium alloys for tracheal stent application P. N. Kumta University ofPittsburgh, USA Met-9

11:40-11:45

ECR-P6 alloy

SOP3- The prospects of EW62 Mg alloy as a structural materialfor biodegradable implants

O. Hakimi University of theNegev, Israel

Met-10

11:45-11:50

Mg-6%Nd-2%Y-0.5% Zr

RS+extrusion

saline solution saturated with Mg(OH)2

slow strain rate

SOP4- Comparative studies of mechanical, corrosion andcytotoxity of MgZnCa and MgZnCa-RES alloys

S. Yarmolenko North CarolinaState University, USA Met-11

11:50-12:10

没说是什么RE

T4 treatment 400C 10h+500C 8h

O7- Benefits and limitations of biodegradable Mg implantsand parts, produced by MIM (metal injection moulding)

M. Wolff Helmholtz-ZentrumGeesthacht, Germany Met-12

12:10-12:15

Pure Mg

Wax as binder

Blending—feedstock

Injection moulding green part

Debinding brown part

Sintering Sinter neck formation

Minimizing of residual porosity

Sensitivity of the process with respect to contaminations

Costs strongly dependent on quantity

Resublimation of Mg

SOP5- Submerged laser microcutting of Mg alloys with NSpulsed green laser for biodegradable stents

A.G. Demir Politecnico diMilano, Italy Met-13

12:15-12:20

Laser microcutting—chemical etching—electrochemical polishing

Dross generation is the most important defect during production ofbiodegradable Mg stent

SOP6- Mechanical properties of extruded antimicrobial Mg-Agalloys Z. Liu Helmholtz-Zentrum Geesthacht, Germany Met-14

12:20-12:25

Mg-6Ag Mg-8Ag

SOP7- Precise extrusion processing of Magnesium alloy smalltube for

biodegradable stentapplication

M. Inoue Fuji Light MetalCo., Japan Met-15

No defect

Fine grain structure

Die structure

Size accuracy

12:25-12:45 O8- Innovativebiodegradable Zinc-based alloys for load-bearing biomedical

implant applications

J.G. Zhou Drexel University,USA

Met-16

Zn alloy 成分保密

250-43MPa 13-33% elongation

Session 2: Metals

Time Title PresenterAffiliation Page

16:00-16:20

O9- Biodegradable Mg alloy with modified nanoscale surfacefor stent

applications

G. Yuan Shanghai Jiao TongUniversity, China Met-17

0.1M KF

MgF2 surface layer(0.8micrometer)

ELISA

Neointimal coverage in both stents are finished in 4 weeks

16:20-16:40

O10- The effect of hot rolling on the microstructure anddegradation

behaviour of a Mg-Ca-Sr alloy

M.V. Manuel University ofFlorida, USA Met-18

Mg-1Ca-0.5Sr

Mg-1Ca-1.5Sr

Main goal determine individual contribution of precipitation reinforcement(precipitate type, size, distribution) grain refine effect

0.25mm thickness reduction

Rolling at 300 degree C and 400 degree C

16:40-17:00

O11- Synthesis and characterization of biodegradablemagnesium-yttrium based alloys for musculoskeletal load-bearing medicalimplants

P. N. Kumta University ofPittsburgh, USA Met-19

Mg12YZn LPSO phase

Mg-Zr-Ca

Mg-Y-Zr-Ca

Mg-Y-Zn-Zr-Ca

17:00-17:05 SOP8- Investigation onzinc based alloys for biodegradable stent applications E. Mostaed Politecnicodi Milano, Italy Met-20

Zn poor strength, desirable ductility, desirable degradation rate

Zn-0.15Mg, 0.5Mg, 3 Mg

Zn-0.5Al(solid solution)

Maximu solubility of Al in Zn solid solution 1.7wt.%

Zn-0.5Al-0.15Mg alloy showed the lowest corrosion rate

Warm extrusion of the minitubes and UFG Zn-based alloys by ECAP

17:05-17:10 SOP9- In vitro degradation ofpure Mg and WE43 alloy in human bile Y.F. Zheng Peking University, China Met-21

17:10-17:15 SOP10- Magnesiumcorrosion under physiological conditions N.A. AghaHelmholtz-Zentrum-Geesthacht, Germany Met-22

HBSS DMEM blood plasma

High purity Mg extruded

Sterilized by sonication in ethanol for 20 mins

Inorganics importance: CaCl2 NaHCO3 MgSO4

17:15-17:20

SOP11- Influence of deformation on the corrosion andcytocompatibility of

biodegradable Mg alloys

B.Y. Peng Xihua University,China Met-23

17:50-18:10 O12- Inflammatoryresponse to Mg-based biodegradable implant materials M. CostantinoHelmholtz-Zentrum Geesthacht, Germany Met-24

18:10-18:15

Anderson, Annu Rev

Response to scaffold implantation

Cytokines production

Early inflammatory reaction 1 day; late inflammatory reaction at 39degreeC 3 day

How to have adherent macrophages in inflammatory in vitro model.

Chemokines=recognize the damage

Inflammatory cytokines=remove the damage

Anti-Inflammatory cytokines =new tissue formation

SOP12- Suitability of novel PLA/Magnesium composites forbiodegradable implants

S.C. Cifuentes CENIM-CSIC,Spain Met-25

18:15-18:20

Pure Mg

SOP13- Metallic magnesium degradation products inhibit humanbreast cancer bone metastasis via multiple signaling pathways

Z.J. Zhai

Shanghai Jiaotong UniversitySchool of Medicine, China

Met-26

18:20-18:25

SOP14- Effects of extracellular magnesium extracts on theproliferation and differentiation of humanosteoblast-osteoclast co-cultures

L.L. Wu Helmholtz-ZentrumGeesthacht, Germany Met-27

18:25-18:30

Acta Biomater 10(2014) 2843-2854

Mg extract + human osteoblast-osteoclast

SOP15- Behaviour of bone cells due to contact to magnesiumimplant material

A. BurmesterHelmholtz-Zentrum Geesthacht, Germany Met-28

18:30-18:50 O13- How does bloodcontact change magnesium degradation?

R. Willumeit-RömerHelmholtz-Zentrum Geesthacht, Germany Met-29

Influence of temperature CO2 andprotein

Influence of salt on corrosion

Composition of blood and plasma

HBSS, DMEM, Plasma(72h) blood(90min,and 6h)

Chandler loop system

FTIR in all cases Mg(OH)2 along withmagnesite=MgCO3

傍晚额外增加了3个环节

1个是介绍了ISO标准，以便本周五讨论；2是建立可降解金属的博客（按Frank Witte说法，也是通过博客分享开会信息等，我就心里笑啦，我这博客就是干这个的吗，比他们想的早）3是确定了明年的开会地点

（虽然还在意大利，但是换地点~(≧▽≦)/~啦啦啦）

（下届会议的最后一天会加上欧盟的医用镁合金大项目一天的结题报告会，你可以听到更多的信息）

（本届会议的参会人数，不包括随行家属等）