专刊介绍
人类表型组是基因组之后生命科学研究的又一战略制高点。表型组学作为一门日益兴起的新交叉学科，涉及构建测量技术体系与标准，构建数据库与系统分析方法，数据采集、图谱构建与应用示范，表型组关键技术开发与整合，表型的跨尺度关联及精细调控机理等研究方向。研究者们致力于揭示表型组学数据在个体层面和群体层面与健康和疾病的关系，并用以预测疾病治疗效果等。而人体肠道表型尤其是对肠道微生物组的精细测绘及分析是人类表型组研究的重要组成部分。
作为人体的“第二基因组”和全新的“代谢器官”，肠道微生物组与人体健康密切相关，贯穿人体“生、老、病、死”的整个生命周期。然而，由于肠道微生物的多样性和复杂性，使这一领域面临重大的研究挑战，但也带来了前所未有的研究机遇。
目前，Phenomics期刊开设专刊“HUMAN GUT MICROBIOME: CHALLENGES AND FUTURE DIRECTIONS”，接收人体肠道微生物组研究领域相关的论著、综述、短评、研究方法等，投稿范围包括但不限于：01核心肠道菌群的探索与讨论;
02菌株水平基因及功能多样性的研究;
03肠道微生物定量方法及相关进展;
04培养组学的最新研究；
05肠道菌与人体健康之间的因果机制研究;
06肠道细菌、病毒及真菌之间的互作;
07靶向肠道微生物的临床干预研究;
08肠道表型组与精准医学。

特邀编委

赵国屏，复旦大学
复旦微生物组中心主任，分子微生物学家，中国科学院院士，发展中国家科学院院士，美国微生物科学院院士。

Sofia Kirke Forslund，德国分子医学中心  

德国分子医学实验和临床研究中心课题组负责人，主要从事心血管、代谢、炎症、自身免疫和精神相关疾病的微生物组研究等。

王则能（Zeneng Wang），美国克利夫兰临床医学中心
美国克利夫兰临床医学中心的心血管与代谢组学科学系教授，从事癌细胞脂质信号转导、过氧化物酶介导的动脉粥样硬化以及哮喘形成机理、肠道细菌参与心脏病的发病机制研究。

吴浩，复旦大学

复旦大学人类表型组研究院及复旦微生物组中心青年研究员、华山医院双聘专家。主要研究饮食与肠道微生物群之间的相互作用，以及它们对代谢性疾病发生、发展及防治的影响。截稿日期：2024年5月31日

专刊详细说明请见：
https://link.springer.com/collections/jhhidaeaag。
投稿指南详见：
https://www.springer.com/journal/43657/submission-guidelines。
备注：投稿时在“Additional information”标签下选择专刊“Human Gut Microbiome: Challenges and Future Directions ”，并在Cover Letter里注明投稿专刊“Human Gut Microbiome: Challenges and Future Directions ”。
如有相关问题，请联系特邀编委负责人（吴浩研究员：hao_w@fudan.edu.cn）或期刊编辑部（phenomics@fudan.edu.cn；phenomics@ihup.org.cn）。
We are pleased to invite you to submit articles, reviews, protocols, brief communications and correspondence to the special issue entitled ' Human Gut Microbiome: Challenges and Future Directions' of Phenomics, a new high-quality journal from Springer Nature, which is dedicated to publishing the finest articles on the emerging field of phenomics.

As the human body's second genome and a newly recognized "metabolic organ", the gut microbiome is linked to almost every aspect of human health across the lifespan. However, due to the vast diversity and intricate complexity observed in the configurations of the human gut microbiome, this field of research presents unprecedented opportunities alongside significant challenges.

In this particular issue of Phenomics, our focus will be on exploring these challenges and drawing inspiration from them to shape future research directions. The topics covered in this issue include, but are not limited to:
-Defining the healthy and core gut microbiome;
-Unveiling bacterial strain differences and functional diversity;
-Robust profiling of gut bacteria: DNA and RNA;
-Culturing the ‘nonculturable’;
-From association to causal studies;
-From intra- to inter-kingdom interactions;
-From bench to bedside;
-From microbiome to phenome and precision medicine.

Submission instructions：
Before submitting your manuscript, please ensure you have carefully read the Submission Guidelines for Phenomics. The complete manuscript should be submitted online through: https://www.editorialmanager.com/pnmc.

To ensure that you submit to the correct special issue, please select the appropriate special issue title under the 'Additional information' tab upon submission. In addition, indicate within your cover letter that you wish your manuscript to be considered as part of the special issue ' Human Gut Microbiome: Challenges and Future Directions '.

All submissions will undergo rigorous peer review as per the journal's editorial policy. Accepted articles will be published within the journal as a collection.

For any questions about a potential submission of this special issue, please contact Dr Hao Wu (hao_w@fudan.edu.cn) or the editorial office of Phenomics (phenomics@fudan.edu.cn) using ‘Human Gut Microbiome: Challenges and Future Directions’ as the email title.