Volume 3  Issue 8

封面解读

刘宁宁

Lung cancer poses a serious threat to public health, and its burden continues to increase substantially worldwide. It ranks as the most prevalent type of cancer and the foremost cause of cancer-related mortality globally, accounting for about one in ten diagnosed cancers and one in five cancer deaths. The microbiome, which could serve as potential diagnostic or prognostic biomarkers, plays a crucial role in carcinogenesis, tumor progression, and the response to anticancer therapy across various tumor types, affecting the clinical outcomes. The role of intratumor polymorphic microbiomes in cancer progression has been demonstrated, yet their interactions at the single-cell level remain unclear. This cover page underscores the tissue type- and cell type-specific microbial distribution and intratumor microbiome–host crosstalk at the single-cell level. We aim to identify the shared and specific characteristics of microbiota–host interactions at the single-cell level to improve personalized treatment strategies against lung cancer.

All Papers

1. Advancing global antifungal development to combat invasive fungal infection

hLife | 上海交大刘宁宁研究团队阐述全球抗真菌药物研发新进展

通讯作者：刘宁宁

本研究团队探讨了全球侵袭性真菌感染的严重威胁，介绍了世界卫生组织（WHO）发布的真菌优先病原体清单（FPPL），并分析了当前真菌诊断和治疗的现状、挑战及新兴策略，如新型抗真菌药物开发、纳米技术和精准医学的应用。

引用：

Wang XL, Ding J, Wong KH, et al. Advancing global antifungal development to combat invasive fungal infection. hLife 2025; 3: 361–363.

2. Crucial functions of gut microbiota on gut–liver repair

hLife | 中国医科大学孙逊团队揭示肠道菌群在肠—肝轴修复中的重要作用

通讯作者：郑倩倩，孙逊

本文结合肠—肝轴双向通讯系统探讨了关键肠道菌群和微生物代谢产物之间的相互作用及其在维持肠道完整性和促进肝脏再生中的关键功能，并对其调控机制和潜在治疗策略进行了深入分析，强调了精准医学框架内个性化微生物干预的前景，对于加速基础研究到临床应用的过渡以及防治相关肠、肝疾病提供了理论基础。

引用：

Wang Y, Yan H, Zheng Q, et al. Crucial functions of gut microbiota on gut–liver repair. hLife 2025; 3: 364–385.

3. Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients

通讯作者：Bassey E. Ekeng

Histoplasma infection affects both the immunocompetent and the immunocompromised, particularly in patients living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). In the former, activities predisposing to severe exposure to Histoplasma conidia including farming, caving, mining, and environmental exposures have been implicated. However, HIV/AIDS remains a major driver of histoplasmosis, often associated with disseminated disease and fatal outcomes.

引用：

Benjamin OE, Bassey TE, Nwagboso CI, et al. Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients. hLife 2025; 3: 386–390.

4. Dissection of intratumor microbiome–host interactions at the single-cell level in lung cancer

hLife | 上海交大刘宁宁等团队揭示肺癌瘤内微生物组与宿主在单细胞水平相互作用机制

通讯作者：吴文娟，郑小琪，刘宁宁

本研究整合了公开发表的6套共149个肺癌患者组织样本的单细胞RNA测序数据集（包含肺癌、癌旁和脑转移组织三种样本类型），利用SAHMI（宿主单细胞-微生物组互作技术）对单细胞转录组测序序列进行分析来识别与单细胞相关的微生物，通过排除潜在的污染和假阳性的微生物序列，同时去除多数据集整合的批次效应，最终确定了与单个宿主细胞相关的真实微生物序列。通过与对应组织的单细胞转录组联合分析，探究了单细胞分辨率下不同类型宿主细胞与肿瘤内特定细菌和真菌相互作用的潜在机制，为理解瘤内微生物组与肺癌发展的关系提供了新理论，有望发现新的癌症诊断和治疗靶点。

引用：

Ma YJ, Sun YC, Wang L, et al. Dissection of intratumor microbiome–host interactions at the single-cell level in lung cancer. hLife 2025; 3: 391–406.

5. Candida albicans overgrowth impairs anti-PD-1 immunotherapy in oral tumor-bearing mice

通讯作者：闫志敏

Candida albicans is one of the most common fungi living in the human gut and oral cavity, and shows associations with the development and prognosis of multiple types of cancer. Our previous study found that C. albicans overgrowth promoted oral cancer development and impaired anti-programmed cell death protein-1 (PD-1) treatment in mice. However, it is unclear whether different levels of C. albicans have different effects on the efficacy of anti-PD-1 therapy for oral cancer. Additionally, whether gut overgrowth of C. albicans influences anti-PD-1 therapy for distant tumor sites is also unknown. 

引用：

Wang X, Zhang X, Wu S, et al. Candida albicans overgrowth impairs anti-PD-1 immunotherapy in oral tumor-bearing mice. hLife 2025; 3: 407–409.

6. Skin microbiome dysbiosis in Prototheca wickerhamii infection

hLife | 上海市东方医院吴文娟团队联合南京鼓楼医院沈瀚团队通过微生物组学揭示了无绿藻皮肤感染过程中的菌群变化特征

通讯作者：吴文娟、沈瀚

本研究将传统的培养方法与微生物组测序技术相结合，全面地解析了受感染皮肤中微生物的多样性。

引用：

Zhang Y, Guo J, Zhu R, et al. Skin microbiome dysbiosis in Prototheca wickerhamii infection. hLife 2025; 3: 410–412.

7. 778th Xiangshan Science Conference convenes experts to explore breakthroughs in lung and respiratory mucosal immunity

通讯作者：王硕

第778次香山科学会议以“肺脏与呼吸道黏膜区域免疫：挑战与机遇”为主题，围绕呼吸道黏膜感染与免疫的研究现状与发展前景、呼吸道黏膜免疫炎症与稳态的新方向与新机遇等中心议题进行深入讨论。

引用：

Yan Q, Wang S, Shi Y. 778th Xiangshan Science Conference convenes experts to explore breakthroughs in lung and respiratory mucosal immunity. hLife 2025; 3: 413–414.

期刊简介

hLife 由高福院士、董晨院士和Jules A. Hoffmann教授（2011诺奖获得者）领衔，是中国科学院微生物研究所主办，中国生物工程学会，浙江大学陈廷骅大健康学院，西湖大学医学院，上海市免疫治疗创新研究院和广州霍夫曼免疫研究所联合支持，与国际出版商爱思唯尔合作的健康科学领域综合性英文期刊。

hLife 聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

hLife是一本金色开放获取期刊，月刊出版；2022年成功入选“中国科技期刊卓越行动计划高起点新刊”；2023年11月正式创刊；2024年5月被DOAJ收录；2024年8月被Scopus收录；2024年10月入选“首都科技期刊卓越行动计划——重点英文科技期刊支持项目”；2025年6月入选北京市科委“2025年度支持高水平国际科技期刊建设-强刊提升”项目；2025年8月入选中国科学引文数据库（CSCD）核心库。

hLife实行高标准与高效率并重的同行评审机制：

• 投稿至给出“是否送审”决定⏰1天

• 投稿至给出“首轮审稿”决定⏰28天

• 投稿至给出“是否录用”决定⏰61天

2026年前hLife接收的稿件免收文章处理费（APC）。

https://www.sciencedirect.com/journal/hlife