SENSITIVE TO PROTON RHIZOTOXICITY 1 (STOP1) is a master transcription factor (TF) that regulates genes encoding proteins critical for cellular pH homeostasis. STOP1 also causes pleiotropic effects in both roots and shoots associated with various stress tolerances. STOP1-regulated genes in roots synergistically confer tolerance to coexisting stress factors in acid soil, and root-architecture remodeling for superior phosphorus acquisition. Additionally, STOP1 confers salt tolerance to roots under low-potassium conditions. By contrast, STOP1 antagonistically functions in shoots to promote hypoxia tolerance but to suppress drought tolerance. In this review, we discuss how these synergetic- and antagonistic-pleiotropic effects indicate that STOP1 is a central hub of stress regulation and that the harmonization of STOP1-regulated traits is essential for plant adaptation to various environments.

 摘 要 

STOP1是编码调控细胞内pH稳态蛋白的关键转录因子。STOP1同时具有多效性功能，作用于植物地下和地上组织的多种胁迫耐受性。STOP1在根中调控的基因协同赋予根在酸性土壤中其它胁迫因子的耐受性和根系结构重建，以获取更好的磷吸收。此外，STOP1在低钾条件下赋予植物根系耐盐性。相反，STOP1在地上部分具有促进耐缺氧，但抑制耐旱的拮抗作用。本综述中，作者讨论了STOP1的协同和拮抗多效性，揭示其是如何成为胁迫调控的核心枢纽，以及受STOP1调控的性状的协调对于植物适应各种环境至关重要。