In this week's issue:
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SPECIAL SECTION |
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Introduction to Special Issue Introduction Robert Coontz et al. Special Issue News Thomas Sumner Over the past century, x-ray crystallography has transformed scientists' understanding of the structure and behavior of materials. Robert F. Service A technique for crystallizing fragile biomolecules without disrupting them is helping researchers probe the structures of some of the body's most important but elusive proteins: those that usher other chemicals through the cell membrane. Special Issue Review Judith A. K. Howard and Michael R. Probert Elspeth F. Garman R. J. Dwayne Miller
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RESEARCH SUMMARIES |
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Editor summaries of this week's papers. Highlights of the recent literature.
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EDITORIAL |
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NEWS OF THE WEEK |
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In science news around the world, scientists find Middle East respiratory syndrome in camels from Africa; Japan launches a test of a space debris cleanup scheme; the U.S. Environmental Protection Agency halts the permit for a large copper mine near Bristol Bay, Alaska; and more. Researchers interested in studying and preventing strokes have their eye on the capybara. The world's largest rodent shuts off a main blood supply to its brain, then manages to compensate by expanding another artery. Theoretical physicist-turned-filmmaker Mark Levinson tells Science about directingParticle Fever, a new documentary on the discovery of the Higgs boson.
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NEWS & ANALYSIS |
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Scientific Misconduct Martin Enserink Lawsuit claims that research leader retaliated against the victim after misconduct was discovered. Virology Jon Cohen Four shots a year with a long-lasting drug may prevent HIV infection in the future. Nutrition Jennifer Couzin-Frankel New data on mice and people suggest low-protein diets enhance health and extend life. Environment Erik Stokstad Laying off staff scientists, the World Wildlife Fund moves away from centralized research to rely more on outsourced expertise. Oceanography David Malakoff Oceanographers have released a digital atlas containing remarkably detailed maps of ocean chemistry. Space Daniel Clery Early in April, Europe will launch the first satellite in its Copernicus program: a fleet of a dozen environmental monitoring spacecraft designed to study Earth's oceans, changes in land use, and atmosphere.
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NEWS FOCUS |
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Robert F. Service The United States is winding down a $1 billion project to churn out protein structures. What will that mean for the field?
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LETTERS |
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William Bruce Weaver Jonathan C. Javitt Peter Andrews
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BOOKS ET AL. |
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Environment Tobias Plieninger Examining the widespread resurgence of woodlands, the authors build a multifaceted view of forests as social-ecological systems. Natural Disasters Donald Turcotte Kieffer offers an engaging, fast-moving introduction to natural disasters caused by Earth's ongoing geological processes. A listing of books received at Science during the week ending 28 February 2014.
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POLICY FORUM |
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Conservation V. Acuña et al. Intermittently flowing streams and rivers should be recognized, afforded protection, and better managed.
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PERSPECTIVES |
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Genetics Robert J. Schmitz In the plant Arabidopsis thaliana, epigenetic variation, like genetic change, is potentially a substrate for Darwinian evolution. [Also see Report by Cortijo et al.] Chemistry Miquel Salmeron An atomic force microscope is used to measure the molecular forces between two carbon monoxide (CO) molecules. [Also see Report by Weymouth et al.] Environment Andrew D. Gronewold and Craig A. Stow Knowledge of the drivers behind recent record low water levels in the North American Great Lakes can help water resource management planning. Geophysics Joseph E. Borovsky A dense cold plasma from Earth's ionosphere can counter strong solar wind. [Also see Report by Walsh et al.] Genetics Peter K. Gregersen Consideration of cell type- and disease-associated environmental conditions is critical to connecting specific genetic variants to immune disorders. [Also see Research Articles by Fairfax et al. and Lee et al.] Medicine Susan M. Rosenberg and Christine Queitsch Molecular mechanisms that generate biological diversity are rewriting ideas about how evolution proceeds, with implications for treating disease.
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RESEARCH ARTICLES |
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Benjamin P. Fairfax et al. Analysis of the transcriptional responses during induced innate immune activity in primary human monocytes is explained. [Also see Perspective by Gregersen] Mark N. Lee et al. Mapping of human host-pathogen gene-by-environment interactions identifies pathogen-specific loci. [Also see Perspective by Gregersen] Sean D. Willett et al. A proxy for river elevation demonstrates the degree to which river networks reorganize and equilibrate.
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REPORTS |
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Alfred John Weymouth et al. Lateral force microscopy reveals the torsional spring constant of a carbon monoxide molecule at the end of an atomic force microscope tip. [Also see Perspective by Salmeron] B. M. Walsh et al. Ground-based and satellite observations show that a plume extends all the way to the magnetopause and can persist for hours. [Also see Perspective by Borovsky] S. Dai et al. Infrared nanoimaging is used to detect a type of surface collective mode in a representative van der Waals crystal. Eirik Vinje Galaasen et al. Deep ocean circulation was less stable during the last interglacial periods than previously supposed. Jonas Y. Lee et al. Structural and functional studies of ABC exporters provide insight into how glutathione derivatives are translocated. Vasundara Srinivasan et al. Structural and functional studies of ABC exporters provide insight into how glutathione derivatives are translocated. Wei-chen Chang et al. Crystallography and spectroscopy detail a key mechanistic step in the microbial biosynthesis of an important antibiotic class. Sandra Cortijo et al. Genetic mapping reveals epigenetic changes associated with flowering time and root length. [Also see Perspective by Schmitz] Henry Chung et al. A methyl-branched cuticular hydrocarbon affects both desiccation resistance and mate choice in related Drosophila species. Chasity D. Andrews et al. Prolonged protection from repeated SHIV challenges is demonstrated in macaques. A. S. Siraj et al. Warmer years promote malaria cases at higher altitudes.
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PODCAST |
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Listen to stories on 100 years of crystallography, firming up the link between climate change and malaria, and more.
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NEW PRODUCTS |
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A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
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FROM THE AAAS OFFICE OF PUBLISHING AND MEMBER SERVICES |
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Science Webinar Series Miguel E. Quiones-Mateu and Volker Endris
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