2024年 医学诺奖得主Victor Ambros 最新论文    

http://www.pubmedplus.cn/P/SearchQuickResult?wd=620febc7-6b37-4701-9f48-7b37d731c613

• 1. MicroRNA-mediated gene regulation and the resilience of multicellular animals.

  Victor Ambros

  University of Massachusetts Chan Medical School, Worcester MA, USA.

  Postepy Biochem (P 0032-5422 E 0032-5422) H指数：13 2024 年 70 卷 1 期 62-70 页

  PMID：39016233 相似文献

  文摘 DOI链接 Postepy Biochem, Inc.

• 2. Modeling neurodevelopmental disorder-associated human AGO1 mutations in Caenorhabditis elegans Argonaute alg-1.

  Ye Duan,Li Li,Ganesh Prabhakar Panzade,Amélie Piton,Anna Zinovyeva,Victor Ambros

  Program of Molecular Medicine, UMass Chan Medical School, Worcester, MA 01605.

  Proc Natl Acad Sci U S A (P 1091-6490 E 0027-8424) H指数：699 2024 年 121 卷 10 期 e2308255121 页

  PMID：38412125 相似文献

  文摘 DOI链接 Atypon

原文

https://pubmed.ncbi.nlm.nih.gov/39016233/

Review

Postepy Biochem

. 2024 May 23;70(1):62-70.

 doi: 10.18388/pb.2021_515. Print 2024 May 23.

MicroRNA-mediated gene regulation and the resilience of multicellular animals

Victor Ambros 1

Affiliations expand

• PMID: 39016233

•  

• DOI: 10.18388/pb.2021_515

Free article

Abstract

MicroRNAs are small RNAs that enable parts of the genome to regulate the other parts of the genome by RNA::RNA complementarity. Genes that encode microRNAs function as trans-acting regulators of hundreds of other genes, primarily by inhibiting the production of protein from mRNAs to which the microRNAs can bind by base pairing. MicroRNAs and their Argonaute partner proteins constitute a regulatory complex (the miRISC) that exhibits astonishing regulatory versatility. microRNAs have been shown to perform diverse roles in genetic regulatory networks (GRNs) - to control developmental switches, to dampen gene expression noise, to coordinate multigene functional modules, and more broadly, to confer robustness and resilience to developmental and homeostatic processes. Genetic analysis reveals that the function of particular microRNAs can be conditional, such that the microRNA is required under particular environmental or physiological conditions, but relatively dispensable under other conditions. The diversity and versatility of microRNA function in animal systems reflects the many ways that miRISC can be regulated by cellular signaling pathways, and the structure-function interplay among microRNA, target, and Argonaute.

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Publication types

• Review

MeSH terms

• Animals

• Argonaute Proteins / genetics

• Argonaute Proteins / metabolism

• Gene Expression Regulation*

• Gene Regulatory Networks

• Humans

• MicroRNAs* / genetics

• MicroRNAs* / metabolism

Substances

• MicroRNAs

• Argonaute Proteins

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