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2024年 医学诺奖得主Victor Ambros 最新论文 2024年2篇
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2024年 医学诺奖得主Victor Ambros 最新论文
http://www.pubmedplus.cn/P/SearchQuickResult?wd=620febc7-6b37-4701-9f48-7b37d731c613
1. MicroRNA-mediated gene regulation and the resilience of multicellular animals.
University of Massachusetts Chan Medical School, Worcester MA, USA.
Postepy Biochem (P 0032-5422 E 0032-5422) H指数：13 2024 年 70 卷 1 期 62-70 页
PMID：39016233 相似文献
Ye Duan,Li Li,Ganesh Prabhakar Panzade,Amélie Piton,Anna Zinovyeva,Victor Ambros
Program of Molecular Medicine, UMass Chan Medical School, Worcester, MA 01605.
Proc Natl Acad Sci U S A (P 1091-6490 E 0027-8424) H指数：699 2024 年 121 卷 10 期 e2308255121 页
PMID：38412125 相似文献
原文
https://pubmed.ncbi.nlm.nih.gov/39016233/
Review
Postepy Biochem
. 2024 May 23;70(1):62-70.
doi: 10.18388/pb.2021_515. Print 2024 May 23.
MicroRNA-mediated gene regulation and the resilience of multicellular animals
Affiliations expand
PMID: 39016233
DOI: 10.18388/pb.2021_515
Free article
Abstract
MicroRNAs are small RNAs that enable parts of the genome to regulate the other parts of the genome by RNA::RNA complementarity. Genes that encode microRNAs function as trans-acting regulators of hundreds of other genes, primarily by inhibiting the production of protein from mRNAs to which the microRNAs can bind by base pairing. MicroRNAs and their Argonaute partner proteins constitute a regulatory complex (the miRISC) that exhibits astonishing regulatory versatility. microRNAs have been shown to perform diverse roles in genetic regulatory networks (GRNs) - to control developmental switches, to dampen gene expression noise, to coordinate multigene functional modules, and more broadly, to confer robustness and resilience to developmental and homeostatic processes. Genetic analysis reveals that the function of particular microRNAs can be conditional, such that the microRNA is required under particular environmental or physiological conditions, but relatively dispensable under other conditions. The diversity and versatility of microRNA function in animal systems reflects the many ways that miRISC can be regulated by cellular signaling pathways, and the structure-function interplay among microRNA, target, and Argonaute.
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Publication types
MeSH terms
Animals
Argonaute Proteins / genetics
Argonaute Proteins / metabolism
Gene Expression Regulation*
Gene Regulatory Networks
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Substances
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