曾经沧海,自信早已洞察这案子的预后,却对三件事感到意外:一是科学网编辑的胸怀,让读者饱了眼福;二是居然有王志明老师插手,而且卓有成效;三是难得有Dr. James Whitfield做了客观公正的评论。现在事件应该已成为历史,在被完全忘记之前,本人想对Dr Whitfield的评论略说几句。因为他的评论不长,为了方便,全文转贴如下(粗体为本人所加):
PPR哈佛PKD:Comment on the Harvard story from Dr. James Whitfield Personal comment from Dr. James Whitfield:
Thank you for sending me this sad story of a person being unable to repeat a laboratory's important experiments. A person from my lab also once went to work in another lab and could not repeat their important published data, but unlike Dr Guo, he wisely left without making trouble. Surely this could, indeed should, should, now be resolved by doing exactly what Dr Chen has done. He appears to have found no or only a very low level of WTPC-2 in the cilia of his MDCK cells. This could mean that these cells don't concentrate normal PC2 in the cilium and that the PC2 that does get there eventually is a non-specific secondary intrusion and that some mutant PCs do somehow get in albeit slowly. But this seems to mean that the PC2 is not a normal cilial component. Thus, the key fact from Dr Chen is that there is a problem here which must be resolved for the sake of those of us who have written about the calcium-mediated mechanodriven signaling from the kidney cell cilium. I am surprised that apparently the Harvard people did not take a little time and effort to defuse this problem by carefully arranging an independently monitored set of experiments to verify or definitively refute Dr Guo's potentially serious observations.
Dr. James Whitfield Researcher Emeritus of the National Research Council of Canada http://www.sciencenet.cn/blog/user_content.aspx?id=224077
Dr Whitfield首先指出,郭先生因为不能重复实验结果就声张质疑的做法不明智,聪明人的做法是不露声色悄悄离开。也就是说对这种事不可大惊小怪,声张起来对大家都没好处。
Milanda Rout April 09, 2009 Article from: The Australian SCIENTISTS were allegedly recruited by a pharmaceutical giant to put their names on research done by the drug company to promote the safety of its anti-arthritis drug Vioxx. The Federal Court has heard that Merck & Co "prepared and gathered" doctors and academics to write the company's own research on Vioxx, which was then published in prestigious medical journals as independent studies. The drug company also allegedly produced an entire journal -- called The Australasian Journal of Bone and Joint Medicine -- and passed it off as an independent peer review publication. These claims were put by lawyers acting for Graeme Peterson, who is suing Merck & Co and its Australian subsidiary Merck, Sharpe and Dohme for compensation. The 58-year-old -- along with more than 1000 other Australians -- claim Vioxx caused their heart attack or stroke. The drug was launched in 1999 and at its height of popularity was used by 80 million people worldwide because it did not cause stomach problems, as did traditional anti-inflammatory drugs. It was voluntarily withdrawn from sale in 2004 after concerns were raised that it caused heart attacks and strokes and a clinical trial testing these potential side-effects was aborted for safety reasons. Merck last year settled thousands of lawsuits in the US over the effects of Vioxx for $US4.85billion ($7.14 billion) but made no admission of guilt. Counsel acting for Mr Peterson, Julian Burnside, told the court this week the drug company sought out and recruited scientists, academics and doctors to put their name to Merck's own research. He said medical journal expert George Jelinek would testify that the articles were designed to "reassure the medical profession" about the safety of Vioxx. The trial, before judge Chris Jessup, continues. http://www.theaustralian.news.com.au/story/0,25197,25311725-5013404,00.html