† Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, United States
‡ MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore
§ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States
∥ Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chungbuk 363-883, Korea
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated fromStreptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi’s universal NMR database.