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美国遗传学家。1995年与艾瑞克·威斯乔斯和克里斯汀·纽斯林-沃尔哈德共享诺贝尔生理医学奖。爱德华·路易斯(英语:Edward B. Lewis,1918年5月20日-2004年7月21日)
https://pubmed.ncbi.nlm.nih.gov/10731135/
Science
. 2000 Mar 24;287(5461):2216-8.
doi: 10.1126/science.287.5461.2216.
Affiliations expand
PMID: 10731135
The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we look at some of the instances in which work on Drosophila has led to major conceptual or technical breakthroughs in our understanding of animal genomes.
The Drosophila genome sequence: implications for biology and medicine.
Science. 2000 Mar 24;287(5461):2218-20. doi: 10.1126/science.287.5461.2218.PMID: 10731136
Nobel prizes: fly development work bears prize-winning fruit.
Science. 1995 Oct 20;270(5235):380-1. doi: 10.1126/science.270.5235.380.PMID: 7569990 No abstract available.
The genome sequence of Drosophila melanogaster.
Science. 2000 Mar 24;287(5461):2185-95. doi: 10.1126/science.287.5461.2185.PMID: 10731132
[Nobel prize in medicine for banana fly research].
Duodecim. 1995;111(24):2357, 2359, 2361 passim.PMID: 9841185 Finnish. No abstract available.
Drosophila melanogaster and the development of biology in the 20th century.
Methods Mol Biol. 2008;420:1-25. doi: 10.1007/978-1-59745-583-1_1.PMID: 18641938 Review.
Front Pharmacol. 2022 Jul 12;13:922457. doi: 10.3389/fphar.2022.922457. eCollection 2022.PMID: 35903326 Free PMC article.
Drosophila as a Model for Microbiota Studies of Neurodegeneration.
J Alzheimers Dis. 2021;84(2):479-490. doi: 10.3233/JAD-215031.PMID: 34569965 Free PMC article. Review.
ACS Omega. 2021 Mar 24;6(13):9176-9187. doi: 10.1021/acsomega.1c00445. eCollection 2021 Apr 6.PMID: 33842786 Free PMC article.
Impact of environmental neurotoxic: current methods and usefulness of human stem cells.
Heliyon. 2020 Dec 19;6(12):e05773. doi: 10.1016/j.heliyon.2020.e05773. eCollection 2020 Dec.PMID: 33376823 Free PMC article. Review.
The Drosophila Malpighian tubule as a model for mammalian tubule function.
Curr Opin Nephrol Hypertens. 2019 Sep;28(5):455-464. doi: 10.1097/MNH.0000000000000521.PMID: 31268918 Free PMC article. Review.
Animals
Animals, Genetically Modified
Chromosome Mapping / history
Cloning, Molecular
Computational Biology / history
Drosophila melanogaster / genetics*
Genes, Insect
Genetics / history*
Genome*
History, 20th Century
Mutation
Nobel Prize
Physical Chromosome Mapping / history
Recombination, Genetic
Sequence Analysis, DNA
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