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吐口水看脑病?唾液vs血液,哪个更能反映精神病患脑部特征?

已有 3681 次阅读 2014-12-25 18:26 |个人分类:Longi Data|系统分类:科研笔记| 大数据, 表观遗传, 唾液, DNA甲基化, longidata

2015新发表的文献:

DNA extracted from saliva for methylation studies of psychiatric traits: Evidence tissue specificity and relatedness to brain.


主要结论:

1. 通过DNA甲基化信息,可以用唾液采集来研究精神疾病;

2. 唾液DNA甲基化比血液variance更大

There was more variability in CpG sites from saliva than blood, which may reflect its heterogeneity.

3. 相对血液,唾液DNA甲基化更“象”脑部变化;

Finally, DNA methylation in saliva appeared more similar to patterns from each of the brain regions examined overall than methylation in blood.


http://www.ncbi.nlm.nih.gov/pubmed/25355443

 



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