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略解今年诺贝尔医学奖的贡献及相关文章
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1.Jules A. Hoffmann 发现果蝇在抗真菌感染中Toll的表达及功能。
http://www.cell.com/retrieve/pii/S0092867400801725
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila AdultsBruno Lemaitre1, Emmanuelle Nicolas1, Lydia Michaut1, Jean-Marc Reichhart1 and Jules A Hoffmann1, *,
2.Bruce A. Beutler 发现TLR4与LPS的相互作用，以及信号转导。
http://www.sciencemag.org/content/282/5396/2085.abstract
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneAlexander Poltorak, Xiaolong He*, Irina Smirnova, Mu-Ya Liu†, Christophe Van Huffel‡, Xin Du,Dale Birdwell, Erica Alejos, Maria Silva, Chris Galanos, Marina Freudenberg, Paola Ricciardi-Castagnoli,Betsy Layton and Bruce Beutler以下为四篇重要的文章：
（1）.Steinman RM, Adams
JC, Cohn ZA Identification of a novel cell type in peripheral
lymphoid organs of mice. 4. Identification and distribution in
mouse spleen. Journal of
experimental medicine. 1975;141:804-820
（2）.Steinman RM, Cohn ZA Identification of a novel cell type in peripheral lymphoid organs of mice. 2. Functional properties in vitro. Journal of experimental medicine. 1974;139:380-397
(3). Steinman RM, Lustig DS, Cohn ZA Identification of a novel cell in peripheral lymphoid organs of mice. 3. Functional properties in vivo. Journal of experimental medicine. 1974;139:1431-1445
(4). Steinman RM, Cohn ZA Identification of a novel cell type in peripheral lymphoid organs of mice. 1. Morphology, quantitation, tissue distribution. Journal of experimental medicine. 1973;137:1142-1162
2011诺贝尔奖
https://blog.sciencenet.cn/blog-463980-493012.html
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