Gas chromatographic separation of enantiomers on novel chiral stationary phases

Author links open overlay panelSheng-MingXieXue-XianChenJun-HuiZhangLi-MingYuanShow morehttps://doi.org/10.1016/j.trac.2020.115808Get rights and content

Highlights

• Advances on various novel CSPs for GC enantioseparation were reviewed during 2010–2019.

• The synthesis strategies to construct chiral porous materials were covered.

• The resolution of different types of enantiomers on the novel CSPs was discussed.

• The chiral recognition mechanisms between novel CSPs and chiral analytes were explained.

• We summarize the advantages and disadvantages of novel CSPs used in GC.

Abstract

Chiral capillary gas chromatography has been widely applied to separate volatile and thermally stable enantiomers due to its advantages of simplicity, high efficiency, fast analysis, good sensitivity, and absence of liquid mobile phases. In the first part of this article, recent research progress (from 2010 to the present) concerning newly developed chiral stationary phases based on cyclofructan derivatives and chiral porous materials, including metal-organic frameworks, covalent organic frameworks, inorganic mesoporous silicas, and molecular cages for use in gas chromatography, and the synthetic strategies for obtaining chiral porous materials, was reviewed. Finally, we discussed in detail the separation performances and chiral recognition mechanisms of novel chiral recognition materials coated on capillary columns towards various types of enantiomers, namely (1) amino acid derivatives; (2) alcohols, amines, and amino alcohols; (3) organic acids; (4) aldehydes and ketones; (5) ethers and epoxides, and (6) esters and other enantiomers.

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Keywords

Gas chromatographyCyclofructanChiral porous materialChiral stationary phaseCapillary columnChiral separation

10.1016@j.trac.2020.115808.pdf

1. 
   

   Gas chromatographic separation of enantiomers on novel chiral stationary phases

   TrAC Trends in Analytical ChemistryVolume 124March 2020Article 115808

1. Sheng-Ming Xie, 

2. Xue-Xian Chen, 

3. Jun-Hui Zhang, 

4. Li-Ming Yuan

2. 
   

   Nanoparticles as stationary and pseudo-station+ary phases in chromatographic and electrochromatographic separations

   TrAC Trends in Analytical ChemistryVolume 30, Issue 3March 2011Pages 484-491

1. Ai-Hong Duan, 

2. Sheng-Ming Xie, 

3. Li-Ming Yuan