自然疗法可以逆转阿尔茨海默病的症状

诸平

Fig. 1 Researchers found that Ziziphus jujuba seeds improve cognitive and motor functions in mice with neurodegenerative diseases, showing promise for future dementia prevention products.

Fig. 2 These dried seeds of a type of jujube called Ziziphus jujuba Miller var. spinosa hold potential in preventing dementia. Credit: Osaka Metropolitan University

据日本大阪公立大学（Osaka Metropolitan University）2024年11月20日提供的消息，在新的研究中，自然疗法可以逆转阿尔茨海默病的症状（Natural Remedy Reverses Alzheimer’s Symptoms in New Study）。原文详见：Tomohiro Umeda, Ayumi Sakai, Rumi Uekado, Keiko Shigemori, Ryota Nakajima, Kei Yamana, Takami Tomiyama. Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice. eLife, 13 September 2024. DOI: 10.7554/eLife.100737.1. https://doi.org/10.7554/eLife.100737.1

用提取物和粉末处理的模型小鼠表现出认知和运动功能的恢复（Model mice treated with extracts and powders exhibit restored cognitive and motor functions）

开发一种突破性的痴呆症药物的努力正在受到关注，但传统药物可能为预防保健提供有价值的见解。

大阪公立大学医学研究生院（Osaka Metropolitan University’s Graduate School of Medicine）特聘教授富山贵美（Takami Tomiyama）领导的研究小组发现，给模型小鼠服用一种名为酸枣（Ziziphus jujuba Miller vars . spinosa）的干种子（酸枣仁），有望恢复其认知和运动功能。

模型小鼠研究的有希望的结果（Promising Results from Model Mice Studies）

研究小组对患有阿尔茨海默病（Alzheimer’s disease）、额颞叶痴呆（frontotemporal dementia）、帕金森氏病（Parkinson’s disease）、路易体痴呆（dementia with Lewy bodies）等疾病的模型小鼠给予酸枣仁（Zizyphi spinosi semen）热水提取物进行实验，结果发现，小鼠的认知功能和运动功能得到了恢复。

此外，当将种子碾碎成粉末并给模型小鼠服用时，研究小组发现，模型小鼠的认知功能恢复到高于对照组小鼠的水平。另外，这些粉末明显抑制了老年小鼠的细胞衰老，并将它们的认知功能提高到与年轻小鼠相似的水平。

此前，研究小组成员分别报告说，在使用夏威夷草药Mamaki（Hawaiian herb Mamaki）和中草药石菖蒲（Acorus gramineus）后，模型小鼠的痴呆症病理得到改善，认知和运动功能得到恢复。

富山贵美教授表示：“我们的研究结果有望开发出中老年人可以自行服用的痴呆症预防产品。”

富山贵美是名流制药株式会社（セレブロファーマ株式会社 / Cerebro Pharma Inc.）的创始人，本研究得到了名流制药株式会社（Cerebro Pharma Inc.）和帝人公司（Teijin Ltd.）的资助。

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Chinese herbal medicine’s potential in preventing dementia

Abstract

Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these diseases to remove toxic proteins, repair damaged neurons, and suppress cellular senescence. As a source for such prophylactic agents, we selected Zizyphi spinosi semen (ZSS), a medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ and tau pathology and cognitive impairment in mouse models of Alzheimer’s disease and frontotemporal dementia. Non-extracted ZSS simple crush powder showed stronger effects than the extract and improved α-synuclein pathology and cognitive/motor function in Parkinson’s disease model mice. Furthermore, when administered to normal aged mice, the ZSS powder suppressed cellular senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression and neurogenesis, and enhanced cognition to levels similar to those in young mice. The quantity of known active ingredients of ZSS, jujuboside A, jujuboside B, and spinosin, was not proportional to the nootropic activity of ZSS. These results suggest that ZSS simple crush powder is a promising dietary material for the prevention of neurodegenerative diseases and brain aging.