来自中南大学的一篇通讯，发表在 African Journal of Pharmacy and Pharmacology。作者根据氢气的抗氧化、抗炎症作用报道，提出可以用氢气治疗骨关节炎的看法。虽然氢气治疗疾病的研究目前已经很多，但仍没有关于关节炎方面的报道。相信氢气对类风湿等关节炎应该有不错的治疗效果。

     活性氧和骨关节炎的关系非常密切。氢气作为一种选择性抗氧化物质，可以中和强毒性自由基。根据最近的研究，本文提出氢气作为一种新的治疗手段可以用于治疗骨关节炎的假说。根据文献检索，本文回顾分析了2011年7月前发表的关于活性氧、骨关节炎和氢气相关的同行评议英文论文。骨关节炎的的病理生理因素非常多，其中活性氧在该疾病的启动和发展中具有重要地位，特别是在软骨细胞坏死和骨质破坏中发挥重要调节作用。由于在许多动物模型和临床疾病中证明氢气的显著治疗价值。本文提出氢气可以通过抗氧化抗炎症治疗骨关节炎的假说。当然要证明该假说，需要许多基础和临床研究来证明。

全文：http://www.academicjournals.org/ajpp/PDF/pdf2012/8%20Feb/Li%20and%20Wang.pdf

Can hydrogen retard the progression of osteoarthritis?

Ding Li and WanChun Wang*

Department of Orthopaedics, the Second Xiangya Hospital of Central South University, Middle Ren-Min Road No. 139, Changsha, Hunan 410011, China.

Accepted 17 January, 2012

There is a direct relationship between reactive oxygen species (ROS) and the progression of osteoarthritis (OA). Hydrogen is considered as a selective antioxidant, which can neutralize the superfluous ROS. This investigation aimed to describe whether hydrogen can be used as a new treatment to retard the progression of OA based on recent studies. The peer-reviewed literature published prior to July, 2011 in the PubMed database was searched using pre-defined search criteria. Articles, published in English, were selected for their relevance to ROS, hydrogen or OA. The pathogenesis of OA is multifactor. Studies have revealed that ROS can contribute to the onset and progression of OA by inducing indispensable chondrocyte death and matrix degradation. Meanwhile, hydrogen is considered to be a selective antioxidant and can be used as a kind of therapeutic medical gas which has recently been explored in animal model and in clinic. We propose a hypothesis that hydrogen may be a new treatment to retard the progression of OA, although further researches need to be carried out in vivo or clinical studies