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氢气分子医学文献汇总（全文并持续更新）
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为了方便本领域的同行随时阅读文献，这里专门整理全部氢分子医学的文献，包括论著、综述和评述，如果有遗漏，请大家提醒我补充，谢谢。适合读者，包括从事自由基化学、生物学的所有人员，对自身和他人健康防护有兴趣的读者。
1. Dole M, Wilson FR, Fife WP.Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 1975; 190(4210):152-4.pdf
2. Buxton, GV, Greenstock, CL., Helman, W.P. et al. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem,1988; 513–886. pdf
3. Kayar SR, Axley MJ, Homer LD, et al. Hydrogen gas is not oxidized by mammalian tissues under hyperbaric conditions.Undersea Hyperb Med, 1994; 21(3):265-75.pdf
4. Gharib B, Hanna S, Abdallahi OM, et al.Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.C R Acad Sci III, 2001; 324(8):719-24. pdf
5. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007; 13: 688-94. pdf scopus
6. Katherine C, Wood, Mark T Gladwin. The hydrogen highway to reperfusion therapy. Nat Med, 2007; 13: 673-4. pdf
7. Fukuda KI, Asoh S, Ishikawa M, et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007; 361: 670-4 pdf
8. Ball J.Recently published papers: more about EGDT, experimental therapies and some inconvenient truths. Crit Care. 2007;11(5):171.pdf review
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10. Buchholz BM, Kaczorowski DJ, Sugimoto R, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury.Am J Transplant. 2008; 8(10):2015-24 pdf
11. Cai JM, Kang ZM, Liu W, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci lett 2008,441(2):167-72 pdf
12. Hayashida K, Sano M, Ohsawa I, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun, 2008,373(1):30-5.pdf
13. Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance, Nutr. Res, 2008,28:137-43 pdf
14. Ohsawa I, Nishimaki K, Yamagata K, et al. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.Biochem Biophys Res Commun, 2008, 377(4):1195-8 pdf
15. Sato Y, Kajiyama S, Amano A, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008; 375(3):346-50. pdf
16. Rochette Luc, Catherine Vergely. Forgotten Radicals in Biology. Int J Biomed Sci. 2008; 4( 4):255-9. pdf review
17. Sun XJ, Zhang JH. Hydrogen-- an endogenous antioxidant in the body. 第二军医大学学报, 2008; 29: 233-5. pdf review
18. Ohta S.Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept.
19. Nakao A, Sugimoto R, Billiar TR, McCurry KR.Therapeutic antioxidant medical gas. J Clin Biochem Nutr. 2009;44(1):1-13.pdf review
20. Nagata K, Nakashima-Kamimura N, Mikami T, et al. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009; 34(2):501-8. pdf
21. Cai JM, Kang ZM, Liu K, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009;1256:129-37.pdf
22. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S.Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.Cancer Chemother Pharmacol. 2009; 64(4):753-61. pdf
23. Zheng XF, Mao YF, Cai JM, Li YH, Liu WW, Sun PL, Zhang JH, Sun XJ, Yuan.HB Hydrogen-Rich Saline Protects against Intestinal Ischemia/Reperfusion Injury in Rats Free Radical Res.2009; 43(5):478-84. pdf
24. Fu Y, Ito M, Fujita Y, et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci lett. 2009; 453(2):81-5. pdf
25. Matchett GA, Fathali N, Hasegawa Y, et al. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.Brain Res. 2009; 1259:90-7. pdf
26. Mao YF, Zheng XF, Cai JM, et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun.2009; 381(4):602-5. pdf
27. Akito Shimouchi, Kazutoshi Nose, Makoto Yamaguchi, Hiroshi Ishiguro Takaharu Kondo. Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk.Biomarker Insights 2009:4 27-32. pdf
28. Kikkawa YS, Nakagawa T, Horie RT, Ito J.Hydrogen protects auditory hair cells from free radicals.Neuroreport. 2009;20(7):689-94. pdf
29. Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K. Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett. 2009; 583(13):2157-9. pdf
30. Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009; 386(2):316-21. pdf
31. Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009 Aug 14;386(1):11-5. 2009; 386(1):11-5. pdf
32. Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y. Zhang JH, Denoblec PJ, Tao HY, Sun XJ.Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats Exp Biol Med.2009; in press pdf
33. Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y,Yan RL, Su N, Ruan CP, Sun XJ, Wang Q.The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res.2009; in press pdf
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35. Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T.Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. 2009 Aug;54(8):1725-9. Epub 2008 Nov 26 pdf
36. Xu J, Zhou JR, Cai JM, Zhu Z, Sun XJ, Jiang CL.Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. Inflammation Res.2009 in press pdf
37. Itoh T, et al. Molecular hydrogen suppresses FcεRI-mediated signal transduction and preventsdegranulation of mast cells. Biochem Biophys Res Commun. 2009. in press pdf
38. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, et al. Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease. PLoS ONE. 2009; 4(9): e7247. doi:10.1371/journal.pone.0007247 pdf
39. Y. Saitoh, Y. Yoshimura, K. Nakano, N. Miwa. Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells.Experimental Oncology 31, 156–162, 2009 pdf
40. Nakao, A, Kaczorowski, D J, Wang, Y, Cardinal, J S, Buchholz, B M, Sugimoto, R, Tobita, K, Lee, S, Toyoda, Y, Billiar, T R, McCurry, K R. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010 May;29(5):544-53. Epub 2009 Dec 24. pdf
41. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G.. Protective Effects of Hydrogen Gas on Murine Polymicrobial Sepsis via Reducing Oxidative Stress and HMGB1 Release. Shock. 2010 Jul;34(1):90-7. pdf
42. Oharazawa H et al.Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury. Investigative Ophthalmology & Visual Science 2010;51:487-492 pdf
43. Qian L, Cao F, Cui J, Huang Y, Zhou X, Liu S, Cai J. Radioprotective effect of hydrogen in cultured cells and mice. Free Radical Res. 2010;44:275-82 pdf
44. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A.Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010;77(2):101-9. pdf
45. George JF, Agarwal A.Hydrogen: another gas with therapeutic potential. Kidney Int. 2010 Jan;77(2):85-7. pdf
46. Liu C, Cui JG, Sun Q, Cai JM. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses
47. Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Sun XJ, Wang Q. Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun.2010; 393:308-13 pdf
48. LI J, WANG C, Zhang JH, CAI JM,
49. Shen MH, Cai JM, Sun Q, He J, Sun XJ, Huo ZL. Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses
50. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N.Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010 Mar;46(2):140-9. Epub 2010 Feb 24. pdf [Abstract] [PDF (250K)]
51. Saitoh Y, Harata Y, Mizuhashi F, Nakajima M, Miwa N. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity.
54. Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, Hou L, Wang G. HYDROGEN GAS IMPROVES SURVIVAL RATE AND ORGAN DAMAGE IN ZYMOSAN-INDUCED GENERALIZED INFLAMMATION MODEL. Shock. 2010 Mar 23. pdf
55. C.H. Chen, M. Anatol, Y. Zhan, W.W. Liu, R.P. Ostrowki, J. Tang, J.H. Zhang. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model Neuroscience. 2010; In Press, pdf
56. Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010 Apr 12. pdf
57.
59. Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr. 2010 May;46(3):269-76. Epub 2010 Apr 23. pdf web
60. Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010 Jun;83(990):509-14.pdf
61. Haruhisa Kawasaki, Jianjun Guan, Kenichi Tamama. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials Biochemical and Biophysical Research Communications, 2010 pdf
65. Ueda Y, Nakajima A, Oikawa T. Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochem Res. 2010 Jul 22. pdf
65. Domoki F, Oláh O, Zimmermann A, Németh I, et al. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatric Research. 2010. pdf
66.
67. Qian LR, li BL,
68. Zhang YF, Sun Q, He B, Xiao J, Wang ZN, Sun XJ. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology.2010; pdf
69.
70. Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.Medical Hypotheses. 2010; pdf in press
71. Sun Q, Cai JM, Liu SL, Liu Y, Xu WG, Tao HY, Sun XJ. Hydrogen-rich saline provides protection against hyperoxic lung injury. J Surg Res. 2011;165:e43–e49 pdf offprint
72. Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2010 Sep 16. pdf
73. Chen X, et al. Lactulose: an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production. Medical Hypotheses 2010
74. Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, Wang H.The Protective Role of Hydrogen
75. Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2010; pdf
76. Sun Q, Cai JM,Zhou JR,Tao HY,Zhang JH,Zhang W,Sun XJ.Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine.
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81. Fang Y. Fu XJ, Gu C, Xu P, Wang Y, Yu WR, Sun Q, Sun XJ,
82.
86. Zhu WJ et al. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrol. Dial. Transplant. (2010) doi: 10.1093/ndt/gfq727 pdf
87. Liu SL, Liu K, Sun Q, Liu WW, Xu WG, Denoble P, Tao HY, Sun XJ. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol. 2011;
88. Hong Y, Chen S, Zhang JM. Hydrogen as a Selective Antioxidant: a Review of Clinical and Experimental Studies.J Int Med Res. 2010; 38: 1893-1903
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