Volume  4  Issue  2

封面解读

张磊亮

Chikungunya virus (CHIKV) has emerged as a significant global health concern. However, the specific interactions between CHIKV and mitochondrial integrity have largely remained unexplored. In this study, we demonstrated that CHIKV infection induces mitochondrial damage through the action of viroporin proteins transframe (TF) and 6K. In contrast, migrasomes, induced by another viral protein, nsP1, play a critical role in clearing damaged mitochondria through mitocy-tosis. Additionally, we identified the arginine residue R37 within the viroporin proteins as crucial for inducing mitochondrial dysfunction by elevating intracellular calcium levels. The cover visually represents the intricate relationship between CHIKV, depicted as the mythical figure Gonggong, and its impact on mitochondria, symbolized by Mount Buzhou, emphasizing the resultant damage. The stone in the upper right represents nsP1, illustrating its protective role in mitigating mitochondrial injury. This artistic representation emphasizes the dual narrative of virulence and cellular resilience observed in our study.

All Papers

1. Metal–organic framework: Nobel recognition of an artificial periodic porous platform

hLife | 金属有机框架（MOF）：诺贝尔奖认证的人工周期性多孔平台

通信作者：姚明水、Kenichi Otake

本文系统阐述了金属有机框架材料的发展历程、科学价值与生物医学相关应用前景，为这一变革阶段提供了前瞻性视角与发展洞见。

引用：

Fang X, Zhang M, Guo J, et al. Metal–organic framework: Nobel recognition of an artificial periodic porous platform. hLife 2026; 4: 63–66.

2. Rabies virus glycoprotein: Structure, function, and antivirals

hLife | 四川大学逯光文研究团队梳理狂犬病毒糖蛋白变构过程的结构特征，助力新药研发

通信作者：逯光文

本文系统总结了糖蛋白构象变化的结构特征及现有中和抗体和防治药物的阻断机制，为抗病毒靶点选择和药物设计提供理论支撑。

引用：

You Y, Yang F, Lin S, et al. Rabies virus glycoprotein: Structure, function, and antivirals. hLife 2026; 4: 67–86.

3. Genetics of protein structures

通信作者：王家槐

Modern molecular biology began with the discovery of the DNA double helix, revealing the physical basis of genetics. Whereas genes carry genetic information in one-dimension, living cells’ functional activities are performed by proteins in the form of three-dimensional structures. With the newly developed artificial intelligence (AI) tool AlphaFold, essentially the whole protein universe has been reliably predicted. This perspective explores the genetic features of protein structures.

引用：

Wang Jh. Genetics of protein structures. hLife 2026; 4: 87–91.

4. Migrasome-driven mitocytosis relieves mitochondrial damage induced by chikungunya virus TF and 6K

hLife | 山一大张磊亮团队揭示基孔肯雅病毒利用迁移体缓解线粒体损伤

通信作者：张磊亮

本研究揭示了CHIKV通过病毒通道蛋白活性对线粒体造成损伤的机制。这一发现不仅阐明了基孔肯雅病毒对线粒体损伤的具体机制，还提出了基孔肯雅病毒感染所产生的迁移体的新功能，即通过胞吐作用缓解线粒体的损伤。

引用：

Wang S, Zhang D, Zhang L. Migrasome-driven mitocytosis relieves mitochondrial damage induced by chikungunya virus TF and 6K. hLife 2026; 4: 92–106.

5. One Health surveillance of bat virome in mainland Southeast Asia and adjacent regions

通信作者：李靖、江佳富、童贻刚

Highlights

• Bat viromes in southern China and Cambodia show strong species-driven differences, with Cambodian bats harboring highly divergent viruses that reveal vast unexplored diversity.

• A porcine epidemic diarrhea virus (PEDV)-related coronavirus in Cambodian bats has a potential recombinant event, indicating bats as a potential PEDV origin.

• The Indochina Peninsula emerges as a hotspot for coronavirus recombination, underscoring the need for expanded “One Health” surveillance.

引用：

Li J, Tian F, Xiang R, et al. One Health surveillance of bat virome in mainland Southeast Asia and adjacent regions. hLife 2026; 4: 107–122.

6. Dual strategies for durable antibodies against SARS-CoV-2: Immune trajectories and viral fitness constraints

hLife | 中国科学院微生物所提出新策略 助力研发可应对高速逃逸病毒的广谱抗体

通信作者：仝舟

引用：

Gao P, Nguyen L, Lobato AC, et al. Dual strategies for durable antibodies against SARS-CoV-2: Immune trajectories and viral fitness constraints. hLife 2026; 4: 123–126.