DNase I | 脱氧核糖核酸酶 I

中文名：脱氧核糖核酸酶 I

CAS：9003-98-9

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：DNase I (EC 3.1.21.1) 脱氧核糖核酸酶是一种降解 DNA 的酶，在细胞外 DNA 的裂解中起着关键作用，对限制炎症反应和维持体内平衡至关重要。外源性脱氧核糖核酸酶在炎症性疾病和癌症中发挥有益作用。

体内：Deoxyribonuclease (0.1 U; i.p.; once daily for 3 days) inhibits liver metastasis, besides results in a greater prolongation of the survival period by combining surgical removal of the primary tumour mass[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c x DBA/2 mice with murine tumour L5178Y-ML cells subcutaneous injection[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for three days Result: Reduced liver weight from 2.26 to 1.55 g, affected the intensity of liver metastasis, reduced the numbers and sizes of metastatic and affected tumour cell arrest. Animal Model: Female BALB/c x DBA/2 mice with murine tumour and surgical removal of subcutaneous tumours[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for 3 days either before or after primary tumour removal Result: Significantly prolongated survival after tumour cell inoculation compared to the untreated group.

参考文献：[1]. Lauková L, et al. Deoxyribonucleases and Their Applications in Biomedicine. Biomolecules. 2020 Jul 11;10(7):1036.[2]. Sugihara S, et al. Deoxyribonuclease treatment prevents blood-borne liver metastasis of cutaneously transplanted tumour cells in mice. Br J Cancer. 1993 Jan;67(1):66-70.