In 1961, Leonard Hayflick and Paul Moorhead collaborated on culturing human embryonic fibroblasts and observed that these cells could only divide approximately 40 to 60 times in vitro before ceasing proliferation and entering a state of senescence. This phenomenon later became known as the "Hayflick Limit," establishing that the number of cell divisions is limited and laying the foundation for cellular aging research.

In 1973, Russian scientist Alexey Olovnikov proposed the telomere theory of aging, explaining why the number of cell divisions is limited.

In 1985, Carol Greider and Elizabeth Blackburn first isolated and confirmed telomerase activity in Tetrahymena cells, providing a feasible approach for reversing cellular aging. This discovery earned them the 2009 Nobel Prize in Physiology or Medicine.

In 1996, Professor Michael Fossel delivered the first-ever special report on "Reversing Human Aging" at the NIH and published an article in JAMA systematically elaborating on aging intervention strategies centered around telomerase activation. This marked the first introduction of the concept of "reversible aging" into mainstream medicine.

In 2021, Bilu Huang proposed The Telomere DNA and Ribosomal DNA co-regulation model for cell senescence (TRCS) of cellular aging, which addresses the shortcomings of the telomere theory of aging. This provides a solid scientific basis and theoretical support for reversing aging and significantly extending human lifespan, heralding an era where humanity can truly achieve rejuvenation and eternal youth.

1961年，伦纳德·海弗利克和保罗·穆尔黑德合作培养了人类胚胎成纤维细胞，并观察到这些细胞在体外分裂大约40到60次后就会停止增殖并进入衰老状态。这一现象后来被称为“海弗利克极限”，证明了细胞分裂次数是有限的，并为细胞衰老研究奠定了基础。

1973年，俄罗斯科学家阿列克谢·奥洛夫尼科夫提出了端粒老化理论，解释了细胞分裂次数为何是有限的。

1985年，卡罗尔·格雷德和伊丽莎白·布莱克本首次从四膜虫细胞中分离并确认了端粒酶活性，这为逆转细胞衰老提供了一个可行的途径。这一发现使她们获得了2009年诺贝尔生理学或医学奖。

1996年，迈克尔·福塞尔教授在美国国立卫生研究院发表了首个关于“逆转人类衰老”的特别报告，并在《美国医学会杂志》上发表了一篇文章，系统地阐述了围绕激活端粒酶的衰老干预策略。这标志着“可逆转衰老”的概念首次被引入主流医学领域。

2021年，黄必录提出了细胞衰老的端粒DNA与核糖体DNA协同调控模型（TRCS），该模型弥补了端粒理论在解释衰老问题上的不足之处。这为逆转衰老、显著延长人类寿命提供了坚实的科学基础和理论支持，预示着人类真正实现返老还童和永葆青春的时代即将到来。