01 片状支架

• 高精度膜片 

• 多尺度膜片 

• 高精度图案

02 管状支架

• 高精度管道

• 类血管支架

可定制参数

03 应用案例

• 细胞行为研究 

常规的3D打印聚合物，精度只能控制在100-200微米数量级，而近场直写打印的支架精度为3-50微米（接近细胞尺度），可以很好地促进细胞粘附、增殖、分化及定向，可用于纯结构调控细胞行为研究。

细胞膜片构建

结构诱导细胞定向

• 器官芯片构建

高精度支架作为柔性线框模具，可实现微纳尺度的高效制造，方便灵活地制造微流控芯片，用于细胞定向、细胞图案化、器官芯片研究。

凝胶芯片制造及细胞定向诱导

多尺度血管芯片制造

• 水凝胶增强

针对软组织修复用水凝胶无法满足强度、韧性和缝合性要求的瓶颈，利用高精度支架作为结构增强相，基于协同增强效应来提高水凝胶的力学性能，提高组织修复成功率。

高精度支架复合GelMA水凝胶用于软骨修复

高精度支架复合fibrin水凝胶用于瓣膜修复

参考文献

[1] Xie Chaoqi, Gao Qing, Wang Peng, et al. Structure-inducedcell growth by 3D printing of heterogeneous scaffolds with ultrafine fibers.Materials & Design, 2019.

[2]Gao Qing, Xie Chaoqi, WangPeng, et al. 3D printed multi-scale scaffolds with ultrafine fibers for providingexcellent biocompatibility. Materials Science and Engineering: C, 2019.

[3] Jin Yuan, Gao Qing, Xie Chaoqi, et al.Fabricationof heterogeneous scaffolds using melt electrospinning writing: Design and optimization. Materials & Design, 2019.

[4] Lv Shang, Nie Jing, Gao Qing, et al. Micro/nanofabrication of brittle hydrogels using 3D printed soft ultrafine fiber moldsfor damage-free demolding. Biofabrication, 2019.

[5] Nie Jing,Gao Qing, Xie Chaoqi, et al. Construction of multi-scalevascular chips and modelling of the interaction between tumours and bloodvessels. Materials Horizons, 2019.

[6] ArielA. Szklanny, Lior Debbi, Uri Merdler, et al. High-Throughput Scaffold Systemfor Studying the Effect of Local Geometry and Topology on the Development and Orientationof Sprouting Blood Vessels. Advanced Functional Materials, 2019.

[7]JetzeVisser, Ferry P.W. Melchels, June E. Jeon, et al. Reinforcement of hydrogelsusing three-dimensionally printed microfibers. Nature Communications, 2015.

[8] Navid T. Saidy, Frederic Wolf, Onur Bas, et al. BiologicallyInspired Scaffolds for Heart Valve Tissue Engineering via Melt Electrowriting.Small, 2019.