Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

第一作者：Nan Shen

 Abstarct 

Flavonoids are a group of natural polyphenol substances abundant in vegetables, fruits, grains, and tea. As plant secondary metabolites, flavonoids play essential roles in many biological processes and responses to environmental factors in plants. Flavonoids are common in human diets and have antioxidant effects as well as other bioactivities (e.g., antimicrobial and anti-inflammatory properties), which reduce the risk of disease. Flavonoid bioactivity depends on structural substitution patterns in their C6-C3-C6 rings. However, reviews of plant flavonoid distribution and biosynthesis, as well as the health benefits of its bioactivity, remain scarce. Therefore, in the present review, we systematically summarize recent progress in the research of plant flavonoids, focusing on their biosynthesis (pathway and transcription factors) and bioactive mechanisms based on epidemic evidence, in vitroand in vivo research, and bioavailability in the human body. We also discuss future opportunities in flavonoid research, including biotechnology, therapeutic phytoproducts, and dietary flavonoids.

类黄酮是一类在蔬菜、水果、谷物以及茶中富含的天然多酚物质。类黄酮作为植物次生代谢产物，在植物的许多生物过程和对环境因子的响应中发挥着重要作用。类黄酮在人类饮食中很常见，具有抗氧化作用以及其他生物活性（如抗菌和消炎特性），能够降低疾病风险。类黄酮的生物活性取决于其C6-C3-C6环的结构性置换模式。然而，关于植物类黄酮的分布和生物合成，以及其生物活性的健康益处等方面的综述仍然很少。因此，本文中作者系统地总结了植物类黄酮的研究进展，重点描述了类黄酮的生物合成途径和调控转录因子，以及基于体内和体外流行病研究的生物活性机制，还有其在人体内的生物利用。作者还讨论了类黄酮研究的未来机遇，包括生物技术、治疗性植物产品和膳食类黄酮。

** 金飚 **

doi: https://doi.org/10.1016/j.foodchem.2022.132531

Journal: Food Chemistry

Published date: July 30, 2022