Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense

第一作者：Marcela Hernández-Coronado

第一单位：纽约大学

第一通讯：Kenneth D. Birnbaum

 Abstarct 

背景+问题：Wounding is a trigger for both regeneration and defense in plants, but it is not clear whether the two responses are linked by common activation or regulated as trade-offs. 

创伤能够诱导植物的再生和防御，但尚不清楚植物如何将这两种响应关联在一起的，或者是如何平衡两种响应的。

主要发现：Although plant glutamate-receptor-like proteins (GLRs) are known to mediate defense responses, here, we implicate GLRs in regeneration through dynamic changes in chromatin and transcription in reprogramming cells near wound sites. 

尽管，已知类谷氨酸受体GLRs介导植物的防御响应，本文中作者发现GLRs会在创伤组织附近的重编程细胞中，通过动态改变染色质和转录参与再生。

结果1-GLRs-再生：We show that genetic and pharmacological inhibition of GLR activity increases regeneration efficiency in multiple organ repair systems in Arabidopsis and maize. 

作者发现，通过遗传或者药理抑制GLR的活性，能够增强拟南芥和玉米多个器官修复系统中的再生效率。

结果2-GLRs-SA：We show that the GLRs work through salicylic acid (SA) signaling in their effects on regeneration, and mutants in the SA receptor NPR1 are hyper-regenerative and partially resistant to GLR perturbation. 

作者发现，GLRs通过水杨酸途径作用于植物的再生，水杨酸受体NPR1基因的功能缺失具有超强的再生能力，并且能够部分免疫GLRs的扰动。

结论：These findings reveal a conserved mechanism that regulates a trade-off between defense and regeneration, and they also offer a strategy to improve regeneration in agriculture and conservation.

本文的研究结果揭示了植物中一个保守的平衡防御和再生的分子机制，同时也为农业和植物资源保护提供了一个改良再生的策略。

** Kenneth Birnbaum **

doi: https://doi.org/10.1016/j.devcel.2022.01.013

Journal: Developmental Cell

​ Published date: February 10, 2022