Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat

第一作者：Fei He

第一单位：堪萨斯州立大学

第一通讯：Eduard Akhunov

 Abstarct 

背景回顾：Allopolyploidy greatly expands the range of possible regulatory interactions among functionally redundant homoeologous genes. 

异源多倍体极大地扩展了功能冗余部分同源基因（homoeologous gene，即异源多倍体中来自于不同亚基因组间的同源基因，定义：Homoeologs are pairs of genes that originated by speciation and were brought back together in the same genome by allopolyploidization.）之间可能的调控互作。

提出问题：However, connection between the emerging regulatory complexity and expression and phenotypic diversity in polyploid crops remains elusive. 

然而，多倍体作物中正在形成的复杂调控与表达和表型多样性之间的关联仍然不清楚。

主要研究：Here, we use diverse wheat accessions to map expression quantitative trait loci (eQTL) and evaluate their effects on the population-scale variation in homoeolog expression dosage. 

本文中，作者利用不同的小麦材料进行表达数量性状位点定位（eQTL），并评估其对部分同源基因表达剂量在群体层面上的变异的影响。

结果1：The relative contribution of cis- and trans-eQTL to homoeolog expression variation is strongly affected by both selection and demographic events. 

顺式和反式eQTL对部分同源基因表达变异的相对贡献受到选择和群体事件的强烈影响。

结果2：Though trans-acting effects play major role in expression regulation, the expression dosage of homoeologs is largely influenced by cis-acting variants, which appear to be subjected to selection. 

尽管反式作用效应在表达调控中起主要作用，但部分同源基因的表达剂量在很大程度上受顺式作用变体的影响，且似乎受到选择的影响。

结果3：The frequency and expression of homoeologous gene alleles showing strong expression dosage bias are predictive of variation in yield-related traits, and have likely been impacted by breeding for increased productivity.

表现出强烈表达剂量偏差的部分同源等位基因的频率和表达，可以预测产量相关性状的变化，可能受到了以提高产量为目的的育种的影响。

结论：Our study highlights the importance of genomic variants affecting homoeolog expression dosage in shaping agronomic phenotypes and points at their potential utility for improving yield in polyploid crops.

本文的研究突出了影响部分同源基因表达剂量的基因组变异在塑造农艺表型中的重要性，并指出了它们在改良多倍体作物产量中的潜在用途。

** Eduard Akhunov **

doi: https://doi.org/10.1038/s41467-022-28453-y

Journal: Nature Communications

 Published date: February 11, 2022